HOME >> BIOLOGY >> NEWS
The ultimate spa: embryonic body wash controls left-right development

La Jolla, Calif.- Humans and other animals may appear to be symmetrical on the outside, but symmetry is only skin deep. Many body organs, such as the stomach, the heart and the liver, are tipped to the right or left side. So how does the developing embryo distinguish left from right? Salk scientists have now discovered that the foundations for the basic left-right body plan are laid by a microscopic 'pump' on the outer surface of the embryo's underside that wafts chemical messengers over to the left side of the body. This sets up a chemical concentration gradient that tells stem cells how and where to develop. The remarkable findings, including movie footage of the 'pump,' are published in the May 20th edition of the journal Cell.

Juan Carlos Izpisa Belmonte and his colleagues studied the ventral node, a small patch of specialized cells on the outer surface of the underside ('ventral' side) of early embryos in many animals. Each cell in the ventral node has a single, rapidly rotating thread (cilium) projecting from the cell surface. Belmonte and colleagues at the University of Tokyo in Japan had previously demonstrated that the ventral node and its rotating cilia influence the left-right body plan, but until now no-one knew the mechanisms involved.

In the current study, Belmonte's team compared the ventral node in embryos of mice, rabbits and fish, and discovered the same mechanism in all these animals: the rapid, clockwise rotation of the whip-like cilia was actively moving fluid from the right side to the left side of the developing embryo.

The Salk scientists were intrigued by the finding because the forest of rotating cilia were more likely to create a whirlpool than a river. "The unidirectional flow produced by the rotation-like movement of the cilia required a specific mechanism because a simple circling movement would have, logically, just produced a vortex," said Belmonte.

Over the next three years, using a combination of
'"/>

Contact: Cathy Yarbrough
yarbrough@salk.edu
858-453-4100 x1290
Salk Institute
19-May-2005


Page: 1 2 3

Related biology news :

1. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
2. Exercise aside, genes may ultimately dictate seniors mobility
3. Fragmented habitats no ultimate refuges for forest-dwelling tropical birds
4. UCLA scientists produce functioning neurons from human embryonic stem cells
5. Not all embryonic stem cell lines are created equal
6. Discredited Korean embryonic stem cells true origins revealed
7. Study: Donated embryos could result in more than 2,000 new embryonic stem cell lines
8. UCLA researchers reprogram normal tissue cells into embryonic stem cells
9. Reprogrammed fibroblasts identical to embryonic stem cells
10. A twist of fate -- Reprogrammed fibroblasts resemble embryonic stem cells
11. Left-right wiring determined by neural communication in the embryonic worm

Post Your Comments:
(Date:3/2/2015)...   Neurotechnology , a provider of high-precision biometric, ... Software Development Kit (SDK). The SentiGaze algorithm enables ... webcams to track eye movements and generate heatmaps based ... can be used for applications such as analysis of ... SDK can also be used to develop interfaces for ...
(Date:2/24/2015)... -- This report analyzes the worldwide markets for Face and Voice ... Voice Biometrics. The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... Latin America . Annual estimates and forecasts are ... analysis is provided for these markets. Market data and analytics are ...
(Date:2/19/2015)... , Feb .19, 2015 Research and Markets ... addition of the "Military Electro-Optical / Infrared ... Technology, by Platform - Forecast to 2020" ... military electro-optical/infrared systems market is expected to reach ... of 7.71%. This report segments the ...
Breaking Biology News(10 mins):Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 3World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 3
(Date:3/2/2015)... Shimadzu Scientific Instruments will showcase several ... and marijuana analysis at the Pittcon 2015 conference and ... at the Ernest N. Morial Convention Center in New ... 3121 to discuss laboratory challenges with Shimadzu’s technical experts ... help save time, money and effort in the lab. ...
(Date:3/2/2015)... YORK and VANCOUVER, British Columbia ... Inc. ("InMed") (CSE: IN; OTCQB: IMLFF), a clinical ... cannabinoid based therapies, today announced that Craig ... company overview during a live webcast at VirtualInvestorConferences.com. ... ET LINK:   http://VirtualInvestorConferences.com > click the ...
(Date:3/2/2015)... 2015 VG Life Sciences, Inc., (OTCQB: ... and infectious diseases, announced that the U.S. Patent ... new composition of matter patent covering methods for ... CLIP. U.S. Patent No. 8957031 ... Sciences, VG1177, a synthetic peptide which has the ...
(Date:2/28/2015)... Phoenix, AZ (PRWEB) February 28, 2015 Increasing ... The World Films launches its first three episodes of The ... a Mile Project this month, as it continues its mission ... the launch, the project's first phase, to “uncover the truth ... form of media. , The GMO Truth Podcast is an ...
Breaking Biology Technology:Shimadzu Scientific Instruments Announces Product Launches, Presentations and Poster Sessions for Pittcon 2015 2Shimadzu Scientific Instruments Announces Product Launches, Presentations and Poster Sessions for Pittcon 2015 3InMed Pharmaceuticals to Present Investor Webcast March 5 2VG Life Sciences Granted Key Composition Of Matter Patent 2VG Life Sciences Granted Key Composition Of Matter Patent 3The Walk a Mile Project Launches “GMO Truth” Podcast 2
Cached News: