HOME >> BIOLOGY >> NEWS
The ultimate spa: embryonic body wash controls left-right development

La Jolla, Calif.- Humans and other animals may appear to be symmetrical on the outside, but symmetry is only skin deep. Many body organs, such as the stomach, the heart and the liver, are tipped to the right or left side. So how does the developing embryo distinguish left from right? Salk scientists have now discovered that the foundations for the basic left-right body plan are laid by a microscopic 'pump' on the outer surface of the embryo's underside that wafts chemical messengers over to the left side of the body. This sets up a chemical concentration gradient that tells stem cells how and where to develop. The remarkable findings, including movie footage of the 'pump,' are published in the May 20th edition of the journal Cell.

Juan Carlos Izpisa Belmonte and his colleagues studied the ventral node, a small patch of specialized cells on the outer surface of the underside ('ventral' side) of early embryos in many animals. Each cell in the ventral node has a single, rapidly rotating thread (cilium) projecting from the cell surface. Belmonte and colleagues at the University of Tokyo in Japan had previously demonstrated that the ventral node and its rotating cilia influence the left-right body plan, but until now no-one knew the mechanisms involved.

In the current study, Belmonte's team compared the ventral node in embryos of mice, rabbits and fish, and discovered the same mechanism in all these animals: the rapid, clockwise rotation of the whip-like cilia was actively moving fluid from the right side to the left side of the developing embryo.

The Salk scientists were intrigued by the finding because the forest of rotating cilia were more likely to create a whirlpool than a river. "The unidirectional flow produced by the rotation-like movement of the cilia required a specific mechanism because a simple circling movement would have, logically, just produced a vortex," said Belmonte.

Over the next three years, using a combination of
'"/>

Contact: Cathy Yarbrough
yarbrough@salk.edu
858-453-4100 x1290
Salk Institute
19-May-2005


Page: 1 2 3

Related biology news :

1. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
2. Exercise aside, genes may ultimately dictate seniors mobility
3. Fragmented habitats no ultimate refuges for forest-dwelling tropical birds
4. UCLA scientists produce functioning neurons from human embryonic stem cells
5. Not all embryonic stem cell lines are created equal
6. Discredited Korean embryonic stem cells true origins revealed
7. Study: Donated embryos could result in more than 2,000 new embryonic stem cell lines
8. UCLA researchers reprogram normal tissue cells into embryonic stem cells
9. Reprogrammed fibroblasts identical to embryonic stem cells
10. A twist of fate -- Reprogrammed fibroblasts resemble embryonic stem cells
11. Left-right wiring determined by neural communication in the embryonic worm

Post Your Comments:
(Date:7/30/2015)... 30, 2015 Cellecta, Inc., a U.S.-based ... analysis and biomarker discovery, announced the release of ... targeting all human protein coding genes. CRISPR technology ... a gene,s function. Cellecta,s new Human Whole Genome ... tool so that researchers can investigate in a ...
(Date:7/23/2015)... (NASDAQ: AWRE ), a leading supplier of biometrics software ... ended June 30, 2015.  Revenue for the ... 33% compared to $6.8 million in the same quarter last ... $0.3 million, or $0.01 per diluted share, which compared to ... period a year ago.  Lower revenue and ...
(Date:7/21/2015)... , July 21, 2015  NXT-ID, Inc. ... a biometric authentication company focused on the growing ... smart wallet, announces that it has filed provisional ... and Method. This invention highlights ... only authorizes an account, but also the user ...
Breaking Biology News(10 mins):CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 2NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 4
(Date:7/30/2015)... ... July 31, 2015 , ... Ralco is honored to announce that ... County Fair to be held August 5-9 in Marshall. The Ralco Enrichment Center is ... from and how agriculture impacts their daily lives. This unique exhibit also features a ...
(Date:7/30/2015)... ... ... The 2015 Market Research Report on the Global Propanol Industry is ... with a focus on the Chinese situation. Major companies included in the propanol market ... Royal Dutch Shell, LG Chem and Zhejiang Xinhua Chemical. , The report provides a ...
(Date:7/30/2015)...   Senomyx , Inc. (NASDAQ: SNMX ), ... discover, develop, and commercialize novel flavor ingredients for the ... results for the second quarter 2015. ... on track to achieve our commercial and financial goals," ... the Company. "Since our last quarterly earnings report, our ...
(Date:7/30/2015)... WARRINGTON, Pa. , July 30, 2015 /PRNewswire/ ... announced that it has received the second $1.0M ... Business Innovation Research (SBIR) grant valued at up ... the company,s aerosolized KL4 surfactant as a potential ... lung injury.  Discovery Labs was awarded an initial ...
Breaking Biology Technology:Ralco Announces Primary Sponsorship of Ralco Enrichment Center at Lyon County Fair 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 2SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 4SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 5SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 6SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 7SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 8SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 9Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3
Cached News: