HOME >> BIOLOGY >> NEWS
The ultimate spa: embryonic body wash controls left-right development

La Jolla, Calif.- Humans and other animals may appear to be symmetrical on the outside, but symmetry is only skin deep. Many body organs, such as the stomach, the heart and the liver, are tipped to the right or left side. So how does the developing embryo distinguish left from right? Salk scientists have now discovered that the foundations for the basic left-right body plan are laid by a microscopic 'pump' on the outer surface of the embryo's underside that wafts chemical messengers over to the left side of the body. This sets up a chemical concentration gradient that tells stem cells how and where to develop. The remarkable findings, including movie footage of the 'pump,' are published in the May 20th edition of the journal Cell.

Juan Carlos Izpisa Belmonte and his colleagues studied the ventral node, a small patch of specialized cells on the outer surface of the underside ('ventral' side) of early embryos in many animals. Each cell in the ventral node has a single, rapidly rotating thread (cilium) projecting from the cell surface. Belmonte and colleagues at the University of Tokyo in Japan had previously demonstrated that the ventral node and its rotating cilia influence the left-right body plan, but until now no-one knew the mechanisms involved.

In the current study, Belmonte's team compared the ventral node in embryos of mice, rabbits and fish, and discovered the same mechanism in all these animals: the rapid, clockwise rotation of the whip-like cilia was actively moving fluid from the right side to the left side of the developing embryo.

The Salk scientists were intrigued by the finding because the forest of rotating cilia were more likely to create a whirlpool than a river. "The unidirectional flow produced by the rotation-like movement of the cilia required a specific mechanism because a simple circling movement would have, logically, just produced a vortex," said Belmonte.

Over the next three years, using a combination of
'"/>

Contact: Cathy Yarbrough
yarbrough@salk.edu
858-453-4100 x1290
Salk Institute
19-May-2005


Page: 1 2 3

Related biology news :

1. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
2. Exercise aside, genes may ultimately dictate seniors mobility
3. Fragmented habitats no ultimate refuges for forest-dwelling tropical birds
4. UCLA scientists produce functioning neurons from human embryonic stem cells
5. Not all embryonic stem cell lines are created equal
6. Discredited Korean embryonic stem cells true origins revealed
7. Study: Donated embryos could result in more than 2,000 new embryonic stem cell lines
8. UCLA researchers reprogram normal tissue cells into embryonic stem cells
9. Reprogrammed fibroblasts identical to embryonic stem cells
10. A twist of fate -- Reprogrammed fibroblasts resemble embryonic stem cells
11. Left-right wiring determined by neural communication in the embryonic worm

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/11/2016)... 2016  higi, the leading retail and omni-channel community ... web and mobile, today announced it has closed ... investors. --> --> ... innovate higi,s health platform – its network of ... including expanding services and programs to retail partners ...
(Date:1/8/2016)... OXFORD, Connecticut , January 8, 2016 ... growing m-commerce market and WorldVentures ® , a privately ... memberships and an Inc. 5000 fastest-growing company ... a strategic investment of $2 million in Nxt-ID to ... members based on Nxt-ID,s Wocket ® , a unique ...
(Date:1/7/2016)... , Jan. 7, 2016 Various factors ... biopharmaceutical products such as biologics and biosimilars. Some ... reduce healthcare expenditure, growing demand for cost-effective alternatives, ... population. Biosimilars are similar versions of their corresponding ... to their quality, safety, and efficacy. The global ...
Breaking Biology News(10 mins):
(Date:2/3/2016)...  With the growing need for better therapeutics, ... therapies such as monoclonal antibodies, recombinant protein therapeutics ... indications are in high demand. Conventionally expression systems ... production of these therapeutics. However, due to issues ... novel approaches and novel expression systems are currently ...
(Date:2/3/2016)... Mass., Feb. 3, 2016 Harvard Apparatus ... biotechnology company developing bioengineered organ implants for life-threatening ... announced that CEO Jim McGorry , will ... Conference on Tuesday, February 9, 2016 at ... City . HART,s presentation will be webcast ...
(Date:2/3/2016)... ... February 03, 2016 , ... ... a new office dedicated to the North American healthcare market. , Aerocom Healthcare, ... healthcare facilities. The company will provide new pneumatic tube systems or expand ...
(Date:2/3/2016)... CA (PRWEB) , ... February 03, 2016 , ... ... of remote Linux and Unix visualization solutions today announced the addition of a ... Preview allows users to see the current state of the remote Linux desktop ...
Breaking Biology Technology:
Cached News: