HOME >> BIOLOGY >> NEWS
This is your fly's brain on drugs

Cocaine addiction wreaks profound changes on the brain, hijacking reward circuits and depressing inhibitory loops to the point that drug seeking and taking become central drivers of behavior. While mammalian models are useful for mapping out the neural complexity of these behaviors, insights into the molecular basis of drug abuse can often be garnered from simple models, such as the fruitfly, Drosophila. In the open-access journal PLoS Biology, Ulrike Heberlein and colleagues describe their discovery of a new gene that modulates sensitivity to cocaine within the cells of the fruitfly's internal clock. They further show that the cells' role in regulating cocaine sensitivity is distinct from its function as a timekeeper.

One known effect of cocaine on Drosophila is loss of "negative geotaxis," or wall climbing, in response to startle. Using this behavior to screen 400 different mutants, the researchers identified seven with an increased response to cocaine, and for two of these, the disrupted gene was the same, Lmo.

While Lmo is found throughout the body, it is enriched in the brain, and its cocaine-related effects appear to localize in the ventral lateral neurons (LNvs), which provide the fly with an internal clock, driving circadian activities even in the absence of light. However, it appears that these neurons modulate cocaine sensitivity independently of their role in controlling circadian rhythms.

Because Lmo-related proteins are found in key areas of mammalian brains, these results may have important implications for understanding innate differences in sensitivity to cocaine in humans, and potentially provide targets for development of drugs to treat or prevent addiction.


'"/>

Contact: Paul Ocampo
pocampo@plos.org
1-415-624-1224
Public Library of Science
22-Nov-2004


Page: 1

Related biology news :

1. Dragonflys metabolic disease provides clues about human obesity
2. Hard-wiring the fruit flys visual system
3. On a flys wing, scientists tally evolutions winners and losses
4. Fruit flys beating heart helps identify human heart disease genes
5. Invasion of the brain tumors
6. Preclinical study links gene to brain aneurysm formation
7. Gene variant is associated with brain anatomy, clinical course of ADHD
8. Human knowledge is based upon directed connectivity between brain areas
9. A sensory organ, not the brain, differentiates male and female behavior in some mammals
10. Reading ability protects brain from lead exposure
11. Strength of connections between brain regions may affect an adolescents response to peer influence

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: This your fly brain drugs

(Date:2/23/2015)... , Feb. 23, 2015 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... provisional patent 62114357 for DISTRIBUTED VOICE DIRECTED ... NXT-ID introduces a new groundbreaking payment method. Payment accounts ... account may only be accessed if both the speech ...
(Date:2/13/2015)... Feb. 13, 2015 ACT Genomics Co., ... aims to transform cancer genomic information into precision ... company has raised US$ 8 million in the its ... Taipei, Taiwan , ACT Genomics ... With the aim to implement next generation sequencing ...
(Date:2/11/2015)... According to a ... Product (Cards and Readers, Biometrics, Controllers, Management Software), ... Healthcare, Education) and By Geography - Global Forecast and Analysis to ... Control Market is expected to reach $10.4 ... of 10.6% between 2014 and 2020. ...
Breaking Biology News(10 mins):NXT-ID Patents Voice Directed Payments 2NXT-ID Patents Voice Directed Payments 3ACT Genomics Raises $8 Million in its First Private Funding Round 2Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4
(Date:2/26/2015)... 2015 The Movement for Indefinite Life ... life extension technologies and awareness. The event is taking ... on March 21st 2015, in a live Google Hangout ... Schulke, Founder of MILE, says, “Our lives are in ... Movement for Indefinite Life Extension is raising awareness about ...
(Date:2/26/2015)... VIEW, Calif. , Feb. 26, 2015 The ... navigate this ever-changing arena, Frost & Sullivan will host its ... & Sullivan Executive MindXchange , March 8 to 10, at ... San Diego, Calif. This event is ... connected healthcare leaders to discuss industry disruptions and how to ...
(Date:2/26/2015)... 2015 Already well respected for accuracy, ... expanding its Length Gauge offerings with new variants of ... , Specifically, HEIDENHAIN’s pencil probe-style SPECTO length gauge series ... Two new 1Vpp, 12mm stroke length variants of the ... is a variant with a weak spring, 0.4N of ...
(Date:2/26/2015)... According to a new market report published by ... (Corn, Soybean, Cotton and Others), Synthetic Biology-Enabled Products and ... and Forecast, 2013 – 2019,”the global agricultural biotechnology market ... is expected to reach USD 28,694.1 million by 2019, ... 2019. , Demand for food production has increased ...
Breaking Biology Technology:Indefinite Life Extension Activists Organize Online Demonstration 2Indefinite Life Extension Activists Organize Online Demonstration 3Embrace the Future of Medical Technologies with Frost & Sullivan 2Embrace the Future of Medical Technologies with Frost & Sullivan 3Accuracy and Versatile Gauging Go Hand in Hand at HEIDENHAIN 2Global Agricultural Biotechnology Market is Expected to Reach USD 28,694.1 Million in 2019 : Transparency Market Research 2Global Agricultural Biotechnology Market is Expected to Reach USD 28,694.1 Million in 2019 : Transparency Market Research 3
Cached News: