Thumbnail sampler of 10 diverse physiology papers from...( occur early in development that come b...)

occur early in development that "come back" after trauma, such as a spinal cord lesion. They observed such genetic "reexpression" in spinal cord injury. Knowing the expression profile of EphA3, A4 and A7 receptors, they are looking at their specific contribution toward regeneration. When they "shut down" the three receptors effect at the same time they observed a better locomotor activity at the acute phase of animal recovery.

Funding: NIH (SNRP, others), State of Kentucky (KSCHIRT), Norton Health Care, American Psychological Association

"Exercise Increases Soluble Vascular Endothelial Growth Factor Receptor-1 (sFlt-1) in Circulation of Healthy Volunteers."

Amelia Purser Bailey, Megan Shparago, Jian-Wei Gu. Physiology & Biophysics, University of Mississippi Medical Center. Physiology 348.4. Featured topic session #770: "Muscle as an endocrine organ."

Physical inactivity a well-established risk factor for cancer, but the molecular mechanisms are unclear. The researchers found that exercise-induced circulating sFlt-1 was associated with a decrease in unbound circulating VEGF. The function of sFlt-01 is to bind to VEGF to block its activity as one the most potent stimulators of blood vessel growth under physiological and pathological conditions. Formation of new blood vessels is a key pathogenic step for development of cancer and atherosclerosis.

"Pulmonary Functome Revealed by Transcriptomes of Six Rat Organs." Zhongming Chen, Jiwang Chen, Tingting Weng, Lin Liu. Physiological Sciences, Oklahoma State University. Physiology 936.5.

Researchers compared normal transcriptomes of rat lung, heart, kidney, liver, spleen and brain on one DNA microarray slide. This novel hybridization system was three times more efficient and significantly more reproducible than standard hybridization. Among the most abundant genes, cd37, ly6a and cathepsin Y haven't been studied in the lung. Their high and specific expre
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4-Apr-2005

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