Funding: NIH (LL), and an American Heart Association pre-doctoral fellowship (ZC)
"Sex Hormones: A Big Player in the Spontaneous Activity of Female but Not Male Rats."
Andrea M Foley1, Rebecca A Duckworth1,2, Marybeth Brown1,3. 1Physical Therapy, University of Missouri, Physical Therapy Dept., 2Biomedical Sciences, 3Center for Gender Physiology. Physiology 347.9.
As people age, sex hormones decline and so does exercise. Researchers found that testosterone replacement had no effect on spontaneous activity, whereas estrogen did. Identifying gender differences and fctors affecting our activity could lead to a better understanding of an aging population. Next they will attempt to determine if the estrogen improved spontaneous activity through behavior, a local muscle-specific response or a combination.
Funding: NASA and National Institute of Aging.
"Estrogen Increases Mitochondrial Efficiency in Cerebral Blood Vessels."
Chris Stirone1, Vincent Procaccio2, Sue P. Duckles1, Diana N. Krause1. 1Department of Pharmacology, College of Medicine, University of California, Irvine, 2Center for Molecular and Mitochondrial Medicine and Genetics. Physiology 909.18.
UCI researchers show for first time that estrogen has an effect on mitochondria in the cells of blood vessels, specifically blood vessels from the brain. They also showed estrogen receptors in the mitochondria. They found that after estrogen treatment, the mitochondria could produce energy more efficiently with lower amounts of damaging free radicals a problem during aging. They believe that the novel mechanism of estrogen action may help explain why pre-menopausal women have a lower incidence of stoke than men of the same age.
Funding: NIH
"PKC beta/Egr-1: a crucial axis in atherosclerosis."
Evis Harja, Barry I Hudson, Yu Shan Zou,
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4-Apr-2005