HOME >> BIOLOGY >> NEWS
Tiny exosomes extracted from donor cells may be 'magic bullet' for drug-free transplants

PITTSBURGH, Nov. 10 Bubble-like nano-scale particles that are shed by dendritic cells may hold the key to achieving transplant tolerance the long-term acceptance of transplanted organs without the need for drugs, suggests a study by University of Pittsburgh researchers published in the Nov. 15 issue of the journal Blood. The results provide some of the first information about what these structures called exosomes actually do.

Exosomes are no larger than 65-100 nanometers 1,000 times smaller than the diameter of a human hair yet each contains a potent reserve of major histocompatibility complex (MHC) molecules. MHC molecules are gene products that cells use to determine self from nonself. Millions of exosomes scurry about within the bloodstream, and while their function has been somewhat of a mystery, researchers are beginning to surmise that they play an important role in immune regulation and response.

Adrian Morelli, M.D., Ph.D., of the University of Pittsburgh's Thomas E. Starzl Transplantation Institute, became intrigued by the tiny exosomes while researching ways to harness dendritic cells, specialized white blood cells that present antigens to other immune system cells, as a means to donor-specific immune tolerance. Considered the "Holy Grail" of transplantation, tolerance means a recipient's immune system fully accepts a donor graft without immunosuppressive drugs and without compromising its ability to respond appropriately to infections. Because certain dendritic cells have tolerance-enhancing qualities, several approaches under study involve giving recipients donor dendritic cells that have been modified in some way. The idea is that the modified donor cells would convince recipient cells that a transplanted organ from the same donor is not foreign.

"What may be a more effective approach is to make use of these tiny, MHC-rich vesicles that we can siphon from donor dendritic cells and that we have found are captured by recipie
'"/>


10-Nov-2004


Page: 1 2 3 4

Related biology news :

1. Prediction of graft-versus-host disease by gene-expression profiling of donors and more
2. Experts urge industry and international donors to prepare pneumococcal vaccines
3. US woman gives birth to baby from worlds first frozen donor egg bank
4. UK sperm donor crisis
5. New stem cell transplantation technique may match donor for every patient
6. Reassuring findings from first study on sperm donor identification
7. Newly created cancer stem cells could aid breast cancer research
8. ESF EURYI award winner aims to stop cancer cells reading their own DNA
9. OHSU turns mouse into factory for human liver cells
10. UCLA scientists produce functioning neurons from human embryonic stem cells
11. UCF research links proteins, stem cells and potential Alzheimers treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: