HOME >> BIOLOGY >> NEWS
Tiny genes may increase cancer susceptibility, Jefferson scientists find

(PHILADELPHIA) New evidence indicates that small pieces of noncoding genetic material known as microRNAs (miRNAs) might influence cancer susceptibility. Differences in certain miRNAs may predispose some individuals to develop cancer, say researchers collaborating in a joint study at the Kimmel Cancer Center at Jefferson in Philadelphia, Ohio State University Medical Center in Columbus and Roswell Park Cancer Institute in Buffalo.

MiRNAs play a number of roles in biological regulation, including development and cell differentiation, helping to determine what type a cell ultimately becomes. But when damaged, they can contribute to cancer by either turning on cancer-causing genes or by inhibiting tumor-blocking genes. The ways that MiRNAs are expressed have been used to profile tumor types in humans.

To see if miRNAs could affect cancer risk, Linda Siracusa, Ph.D., associate professor of microbiology and immunology at Jefferson Medical College of Thomas Jefferson University, research associate Cinzia Sevignani, Ph.D., and co-workers George Calin, M.D., Ph.D., and Carlo M. Croce, M.D., at Ohio State University in Columbus and Peter Demant, M.D., Ph.D., at Roswell Park Cancer Institute in Buffalo compared the mouse chromosome locations of genes known to affect cancer susceptibility or "susceptibility loci" in eight different types of tumors to the locations of mouse miRNAs.

Reporting in the journal Proceedings of the National Academy of Sciences, the team showed that overall, miRNAs were found 1.5 times more likely to be in susceptibility regions than in non-susceptibility regions. "MiRNAs appear to be frequently located near places in the mouse genome that affect cancer susceptibility," the researchers say, suggesting that miRNAs could be "a new family of cancer tumor susceptibility genes."

Susceptibility loci are forms of the same gene. While one form may give a person a higher risk of developing a cancer, an alternate fo
'"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
23-May-2007


Page: 1 2

Related biology news :

1. Interaction of just 2 genes governs coloration patterns in mice
2. Gene regulation, not just genes, is what sets humans apart
3. Study finds gender differences in renal and other genes contributing to blood pressure
4. New databases put wings on search for bipolar risk genes
5. Research teams uncover risk genes for multiple sclerosis
6. Risk genes for multiple sclerosis uncovered
7. Sour taste make you pucker? It may be in your genes
8. U-M, Israeli scientists report major advance in search for genes associated with colon cancer
9. Rapid evolution of defense genes in plants may produce hybrid incompatibility
10. Alcohol abuse is in the genes
11. St. Jude study shows genes play an unexpected role in their own activation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/13/2019)... ... June 13, 2019 , ... Global Clinical ... serving the end-to-end clinical and ancillary supply chain management needs of large- and ... research organizations, today announced it will sponsor a summer education program offered by ...
(Date:6/6/2019)... ... 2019 , ... MedTech Breakthrough , an independent organization ... technology market, announced that it has selected Medacta International’s MySpine® MC platform as ... 2019 MedTech Breakthrough Awards program. , Medacta® is an international ...
(Date:6/4/2019)... ... June 04, 2019 , ... In’Tech Medical SAS ( http://www.intech-medical.com ... revenues of $31M, up 12% from Q1-18. The growth is associated with uptick ... operational excellence initiatives worldwide. , Laurent Pruvost , President & CEO of ...
Breaking Biology News(10 mins):
(Date:5/2/2019)... ... 02, 2019 , ... Stay on top of current hot topics through free ... to all webinars is free, so be sure to register today to save your ... http://www.xtalks.com to see our upcoming webinars: , CLINICAL TRIALS , May 7 – ...
(Date:4/25/2019)... ... 23, 2019 , ... Frank is an albino, deaf Great Dane. His owners rescued him when ... his health issues. Despite his hearing impairment, he was always an active and playful pup. ... all day, every day. As the two grew, playtime became rougher and Frank ended up ...
(Date:4/16/2019)... ... 2019 , ... On April 24th, the Federal Laboratory Consortium ... for Environmental Health Research (USACEHR), with an award for their cooperative effort in ... company located at the Frederick Innovative Technology Center, Inc. (FITCI) on Metropolitan Court, ...
(Date:4/12/2019)... ... April 12, 2019 , ... An upcoming episode of Advancements ... innovative tools and devices being used to enhance cognitive skills. This episode is ... segment of Advancements will focus on Sound for Life, a neurotechnology company helping ...
Breaking Biology Technology:
Cached News: