DALLAS March 22, 2007 A tiny snippet of RNA, a chemical cousin of DNA, controls damage to the heart under several types of stress, researchers at UT Southwestern Medical Center have found.
The published discovery, appearing online today on Science Express and in a later edition of Science magazine, could mean that blocking the small molecule might become a way to prevent or treat heart damage, the scientists say.
"We've discovered a new and completely unanticipated mechanism for regulating the contractility of the heart," said Dr. Eric Olson, chairman of molecular biology and senior author of the study. "We're very excited about the therapeutic implications, but we still have much work left to do."
Dr. Olson is director of the Nancy B. and Jake L. Hamon Center for Basic Research in Cancer and the Nearburg Family Center for Basic Research in Pediatric Oncology.
When adult heart cells contract, they use two forms of a protein called myosin. One form, called alpha-myosin heavy chain, is fast and efficient, while beta-myosin heavy chain is slower and less efficient. When the heart is damaged, the amount of alpha-myosin decreases and the proportion of beta-myosin increases.
The research focused on a small RNA molecule called a microRNA named miR-208, which occurs almost exclusively in heart muscle. The molecule is made by a portion of the gene that codes for the alpha-myosin protein.
"We speculated that it had an important function, since it was located in such an important gene," said Dr. Eva van Rooij, a postdoctoral researcher in molecular biology and the study's lead author.
The scientists genetically engineered a group of mice so they couldn't produce miR-208. The mice were then subjected to conditions that would normally damage the heart and increase the amount of beta-myosin. Those conditions included hypothyroidism, treatment with a protein that causes heart enlargement
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Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
22-Mar-2007