HOME >> BIOLOGY >> NEWS
Tiny scaffolding allows stem cells to become working fat cells

COLUMBUS, Ohio -- Researchers here have used a new microscopic, three-dimensional scaffolding to coax mouse stem cells to transform themselves into fat cells, and then to function identical to how fat cells naturally do in the body.

While other studies have previously grown fat cells, or adipocytes, in the laboratory, those cells never completely functioned in the same way they do in normal tissue. They failed to produce the genetic and biologic components that all cells require to do their work.

This discovery offers hope of a new approach to growing fat tissue for use in breast reconstruction surgery and other clinical needs, and may even be important for curing type II diabetes.

Douglas Kniss, professor of obstetrics and gynecology and of biomedical engineering at Ohio State University, reported this progress in the current issue of the journal Tissue Engineering.

"There is a serious shortage of transplantable organs available for thousands of patients nationally," Kniss said. "One ultimate goal of this work might be creating new tissue that could serve either as a temporary substitute while waiting for a donor organ, or even providing a replacement organ."

Along with Xihai Kang and Yubing Xie, both postdoctoral fellows in his laboratory, Kniss built a fabric-like carpet of polyethylene terephathalene (PET), or Dacron, fibers that served as scaffolding upon which new fat cells were grown.

In conventional cell cultures, cells usually grow as flat deposits bathed in growth medium. While useful, these "two-dimensional" patches fail to mimic all the tasks performed by cells in vivo. Specific genes, proteins and hormones normally produced by healthy cells are often absent in two-dimensional colonies.

"The PET fibers are spun out onto a mat that resembles the intracellular matrix that bonds cells together in normal tissue. The fibers are about the size of a collagen fiber, several nanometers (a billionth of a mete
'"/>

Contact: Douglas Kniss
kniss.1@osu.edu
614-293-4496
Ohio State University
22-Mar-2005


Page: 1 2 3

Related biology news :

1. Bedsores and bald hides: Novel roles revealed for a scaffolding protein
2. Presence of wolves allows aspen recovery in Yellowstone
3. Cannibalism of the young allows individual fish to specialize
4. Social tolerance allows bonobos to outperform chimpanzees on a cooperative task
5. Expedition allows teachers to participate in polar research
6. Remarkable physiology allows crucian carp to survive months without oxygen
7. 100,000 year-old DNA sequence allows new look at Neandertals genetic diversity
8. New approach allows closer look at smoker lungs
9. Why nerve cells work faster than the theory allows
10. A new tree of life allows a closer look at the origin of species
11. Parachuting allows krill to eat and run

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/18/2020)... ... 17, 2020 , ... Commercial launch readiness is a critical stage in a ... cure or vaccine, the global economic downturn will only increase price pressures overall for ... and capturing full value from every product launch is critical. However, history shows that ...
(Date:7/4/2020)... ... July 03, 2020 , ... Aesthetics ... recognition and multiple awards for not only the products and treatments developed, but ... and Vivace® Microneedle RF. All the brands built by ABM have received several ...
(Date:7/1/2020)... ... July 01, 2020 , ... ... completed the purchase of Teva-Takeda Pharmaceuticals’ packaging facility in Minakuchi, located in the ... clinical supply facility located in Kakegawa, the new 60,000-square-foot facility will provide customers ...
Breaking Biology News(10 mins):
(Date:8/31/2020)... ... August 29, 2020 , ... ... Nutrition manufacturing capability in Wuxi, China. The new plant operation will provide the ... and advanced technology. , “This facility will improve the flexibility of our ...
(Date:8/15/2020)... ... August 13, 2020 , ... Inc. magazine today revealed ... prestigious ranking of the nation’s fastest-growing private companies. The list represents a unique ... independent small businesses. Intuit, Zappos, Under Armour, Microsoft, Patagonia, and many other well-known ...
(Date:8/12/2020)... ... August 11, 2020 , ... Modality ... for free its new white paper – Simulated Transport Methodologies. Regulatory expectations ... biologics licensing application (BLA). In response, Modality Solutions shares an explanation of ...
(Date:8/7/2020)... ... August 06, 2020 , ... VGXI, a ... has closed on the purchase of greenfield for a new, expanded manufacturing facility. ... over 21 acres in the initial acquisition, with an option to purchase an ...
Breaking Biology Technology:
Cached News: