HOME >> BIOLOGY >> NEWS
Tiny scaffolding allows stem cells to become working fat cells

COLUMBUS, Ohio -- Researchers here have used a new microscopic, three-dimensional scaffolding to coax mouse stem cells to transform themselves into fat cells, and then to function identical to how fat cells naturally do in the body.

While other studies have previously grown fat cells, or adipocytes, in the laboratory, those cells never completely functioned in the same way they do in normal tissue. They failed to produce the genetic and biologic components that all cells require to do their work.

This discovery offers hope of a new approach to growing fat tissue for use in breast reconstruction surgery and other clinical needs, and may even be important for curing type II diabetes.

Douglas Kniss, professor of obstetrics and gynecology and of biomedical engineering at Ohio State University, reported this progress in the current issue of the journal Tissue Engineering.

"There is a serious shortage of transplantable organs available for thousands of patients nationally," Kniss said. "One ultimate goal of this work might be creating new tissue that could serve either as a temporary substitute while waiting for a donor organ, or even providing a replacement organ."

Along with Xihai Kang and Yubing Xie, both postdoctoral fellows in his laboratory, Kniss built a fabric-like carpet of polyethylene terephathalene (PET), or Dacron, fibers that served as scaffolding upon which new fat cells were grown.

In conventional cell cultures, cells usually grow as flat deposits bathed in growth medium. While useful, these "two-dimensional" patches fail to mimic all the tasks performed by cells in vivo. Specific genes, proteins and hormones normally produced by healthy cells are often absent in two-dimensional colonies.

"The PET fibers are spun out onto a mat that resembles the intracellular matrix that bonds cells together in normal tissue. The fibers are about the size of a collagen fiber, several nanometers (a billionth of a mete
'"/>

Contact: Douglas Kniss
kniss.1@osu.edu
614-293-4496
Ohio State University
22-Mar-2005


Page: 1 2 3

Related biology news :

1. Bedsores and bald hides: Novel roles revealed for a scaffolding protein
2. Presence of wolves allows aspen recovery in Yellowstone
3. Cannibalism of the young allows individual fish to specialize
4. Social tolerance allows bonobos to outperform chimpanzees on a cooperative task
5. Expedition allows teachers to participate in polar research
6. Remarkable physiology allows crucian carp to survive months without oxygen
7. 100,000 year-old DNA sequence allows new look at Neandertals genetic diversity
8. New approach allows closer look at smoker lungs
9. Why nerve cells work faster than the theory allows
10. A new tree of life allows a closer look at the origin of species
11. Parachuting allows krill to eat and run

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... KEY FINDINGS The global market for stem ... 25.76% during the forecast period of 2017-2025. The rise ... growth of the stem cell market. Download ... The global stem cell market is segmented on the ... cell market of the product is segmented into adult ...
(Date:3/30/2017)... 2017 Trends, opportunities and forecast in this ... technology (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, ... end use industry (government and law enforcement, commercial and ... and others), and by region ( North America ... Asia Pacific , and the Rest of the ...
(Date:3/24/2017)... Research and Markets has announced the addition ... Trends - Industry Forecast to 2025" report to their offering. ... The Global Biometric ... of around 15.1% over the next decade to reach approximately $1,580 ... market estimates and forecasts for all the given segments on global ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... , ... October 10, 2017 , ... ... and business process optimization firm for the life sciences and healthcare industries, announces ... conference in San Francisco. , The presentation, “Automating GxP Validation for Agile Cloud ...
(Date:10/9/2017)... ... ... At its national board meeting in North Carolina, ARCS® Foundation ... Physics and Astronomy, has been selected for membership in ARCS Alumni Hall of ... Breakthrough Prize in Fundamental physics for the discovery of the accelerating expansion of the ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... genomic technologies, launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first ... accompanying cloud-based bioinformatics software to perform Hi-C metagenome deconvolution using their own ...
(Date:10/5/2017)... ... , ... LabRoots , the leading provider of educational and interactive virtual ... to cancer research with a month-long promotion supporting the advancement of breast cancer research ... use promo code PinkRibbon to get 10 percent off their purchase of every the ...
Breaking Biology Technology:
Cached News: