HOME >> BIOLOGY >> NEWS
Tips from the Journals of the American Society for Microbiology

Newly Identified Inhibitor of Anthrax Toxin May Contribute to Safer Vaccine and Offer Postexposure Therapy

A newly identified inhibitor of the anthrax toxin may be used to develop a safer and more effective vaccine and act as a therapeutic agent after exposure say researchers from Massachusetts and Germany. Their findings appear in the June 2005 issue of the journal Infection and Immunity.

Anthrax is a highly contagious and toxic disease that results from infection with the bacterium Bacillus anthracis. If not caught immediately, those infected may die within a matter of days. Anthrax poses a deadly threat as a potential biological weapon placing added emphasis on the need for a safe and effective vaccine. The vaccine currently available doesn't protect against the bacilli and may be hazardous to its host when used immediately after exposure.

In the study researchers infected two groups of mice with anthrax and immunized one group with a dominant-negative inhibitor (DNI) and the other with a protective antigen (PA) currently used in the anthrax vaccine. They monitored the mice for several weeks and found that DNI alone produced higher immune responses than PA. Due to DNI's ability to inhibit the anthrax toxin, researchers also believe that DNI-based vaccines may increase immunity and provide therapeutic activity when administered postexposure.

"The strong immunogenicity and retained antigenicity of DNI suggest that DNI is a promising and potentially safer candidate for use in an anthrax vaccine than PA," say the researchers. "Moreover, in the event of anthrax infection, the administration of DNI can serve not only as an antitoxic therapy as an immediate response but also as a prophylactic vaccine to prevent late-onset or future anthrax infection."

(B.A. Aulinger, M.H. Roehrl, J.J. Mekalanos, R.J. Collier, J.Y. Wang. 2005. Combining anthrax vaccine and therapy: a dominant-negative inhibitor of anthrax toxin
'"/>

Contact: Carrie Patterson
cpatterson@asmusa.org
202-942-9389
American Society for Microbiology
17-Jun-2005


Page: 1 2 3

Related biology news :

1. Tips from the Journals of the American Society for Microbiology
2. Tips from the Journals of the American Society for Microbiology
3. Tips from the Journals of the American Society for Microbiology
4. Tips from the Journals of the American Society for Microbiology
5. Tips from the Journals of the American Society for Microbiology
6. Tips from the Journals of the American Society for Microbiology
7. Tips from the Journals of the American Society for Microbiology
8. Tips from the Journals of the American Society for Microbiology
9. Oxford Journals release preliminary findings from open access experiments
10. Oxford Journals share evidence-based open access results with the community
11. Oxford Journals open access workshop

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tips from the Journals the American Society for Microbiology

(Date:7/27/2014)... Using data from over 18,000 patients, scientists have ... involved in Parkinson,s disease, including six that had ... Nature Genetics , was partially funded by ... by scientists working in NIH laboratories. , "Unraveling ... understanding the multiple mechanisms involved in this complex ...
(Date:7/25/2014)... summer and some of the smoke from those fires is ... by the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard the Aqua ... descended over the Great Lakes region of the United States. ... July 23, 2014 (first image feature highlighted below) clearly shows ... In the image, it is over Manitoba and ...
(Date:7/25/2014)... associate professor of biomedical engineering at the University ... tissue engineering and artificial organ development., "Introduction to ... guide to entering into the field of artificial ... of biomedical engineering at UH, served as a ... while there are other published books on the ...
Breaking Biology News(10 mins):NIH scientists find 6 new genetic risk factors for Parkinson's 2University of Houston researcher publishes textbook on tissue engineering 2
(Date:7/25/2014)... The Conferee Networking committee is pleased to ... These two-hour sessions provide a unique networking opportunity for ... discuss new techniques, or brainstorm new ideas in an ... for consideration is August 31, 2014, and instructions can ... committee will review the topics, and status notifications will ...
(Date:7/25/2014)... , July 25, 2014 /PRNewswire-iReach/ -- Xybion Corporation, ... for global corporations operating in highly regulated industries, ... first annual Global User Group Conference, Xybion International ... Philadelphia, Pennsylvania at the Sheraton ... http://photos.prnewswire.com/prnh/20140724/130263 This year,s conference ...
(Date:7/24/2014)... 24, 2014 -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the "Company") ... active control Phase 3 study of Zerenex (ferric citrate), ... the treatment of hyperphosphatemia in patients with end-stage renal ... and iRon delivery with FErric CiTrate in EsrD) was ... American Society of Nephrology ( JASN ). ...
(Date:7/24/2014)...  Now available is a stem cell therapy that ... , located in Guadalajara, Mexico , ... new health option: stem cell therapies for sports ... suffer from joint and muscle injuries due to professional ... rotator cuff, tennis elbow, and knee injuries. Throughout life ...
Breaking Biology Technology:Pittcon 2015 Announces Call for Topics for Conferee Networking Sessions 2Xybion Announces It Will Host International User Conference in Philadelphia 2Xybion Announces It Will Host International User Conference in Philadelphia 3Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 4Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3
Cached News: