HOME >> BIOLOGY >> NEWS
Tips from the Journals of the American Society for Microbiology

Newly Identified Inhibitor of Anthrax Toxin May Contribute to Safer Vaccine and Offer Postexposure Therapy

A newly identified inhibitor of the anthrax toxin may be used to develop a safer and more effective vaccine and act as a therapeutic agent after exposure say researchers from Massachusetts and Germany. Their findings appear in the June 2005 issue of the journal Infection and Immunity.

Anthrax is a highly contagious and toxic disease that results from infection with the bacterium Bacillus anthracis. If not caught immediately, those infected may die within a matter of days. Anthrax poses a deadly threat as a potential biological weapon placing added emphasis on the need for a safe and effective vaccine. The vaccine currently available doesn't protect against the bacilli and may be hazardous to its host when used immediately after exposure.

In the study researchers infected two groups of mice with anthrax and immunized one group with a dominant-negative inhibitor (DNI) and the other with a protective antigen (PA) currently used in the anthrax vaccine. They monitored the mice for several weeks and found that DNI alone produced higher immune responses than PA. Due to DNI's ability to inhibit the anthrax toxin, researchers also believe that DNI-based vaccines may increase immunity and provide therapeutic activity when administered postexposure.

"The strong immunogenicity and retained antigenicity of DNI suggest that DNI is a promising and potentially safer candidate for use in an anthrax vaccine than PA," say the researchers. "Moreover, in the event of anthrax infection, the administration of DNI can serve not only as an antitoxic therapy as an immediate response but also as a prophylactic vaccine to prevent late-onset or future anthrax infection."

(B.A. Aulinger, M.H. Roehrl, J.J. Mekalanos, R.J. Collier, J.Y. Wang. 2005. Combining anthrax vaccine and therapy: a dominant-negative inhibitor of anthrax toxin
'"/>

Contact: Carrie Patterson
cpatterson@asmusa.org
202-942-9389
American Society for Microbiology
17-Jun-2005


Page: 1 2 3

Related biology news :

1. Tips from the Journals of the American Society for Microbiology
2. Tips from the Journals of the American Society for Microbiology
3. Tips from the Journals of the American Society for Microbiology
4. Tips from the Journals of the American Society for Microbiology
5. Tips from the Journals of the American Society for Microbiology
6. Tips from the Journals of the American Society for Microbiology
7. Tips from the Journals of the American Society for Microbiology
8. Tips from the Journals of the American Society for Microbiology
9. Oxford Journals release preliminary findings from open access experiments
10. Oxford Journals share evidence-based open access results with the community
11. Oxford Journals open access workshop

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tips from the Journals the American Society for Microbiology

(Date:10/31/2014)... 2014  HITLAB SM , a healthcare innovation ... inaugural HITLAB Innovators Summit SM on December ... will partner with the Clinton Foundation,s Health Matters ... Columbia Business School Alumni Club of ... and Operations Research, bringing together leaders in healthcare ...
(Date:10/30/2014)... animals begin life, cells immediately begin accepting assignments to ... mammals, including humans, are special. The cells of mammalian ... to become the protective placenta or to commit to ... step that research from Michigan State University has revealed ... of PLOS Genetics , provide insights ...
(Date:10/30/2014)... in the gastrointestinal tract fulfill many vital functions ... bacteria can induce strong inflammatory responses by the ... enter the bloodstream. , Although acute inflammation is ... or systemic inflammation is linked to numerous disorders ... of inflammatory processes in the development of psychiatric ...
Breaking Biology News(10 mins):HITLAB Announces Inaugural HITLAB Innovators Summit 2HITLAB Announces Inaugural HITLAB Innovators Summit 3Identifying the source of stem cells 2Breakdown in gut barriers to bacteria may promote inflammation and craving in alcoholics 2
(Date:10/31/2014)... This is a professional and in-depth ... The report provides basic biocides information, including its ... well as industry overview. This research covers the ... well as Global industry analysis covering macroeconomic environment ... Chinese biocides industry covers information on ...
(Date:10/31/2014)... New York, NY (PRWEB) October 31, 2014 ... sectors such as healthcare, construction, finance and consumer ... applications. For this reason, industry research firm IBISWorld ... Software industry to its growing industry report collection. ... that develop software for biometric technologies such as ...
(Date:10/30/2014)... LONDON , October 30, 2014 ... Organovo Holdings Inc. (NYSE MKT: ONVO), Medivation Inc. (NASDAQ: ... PCYC ), Synthetic Biologics Inc. (NYSE MKT: SYN), and ... five companies can be accessed at: http://investor-edge.com/register ... Composite ended at 4,549.23, down 0.33%, the Dow Jones ...
(Date:10/30/2014)... October 30, 2014 On October ... Medicine Showcase in Chicago, leading applied stem cell ... Dr. Wade McKenna presented talks on New Techniques ... Surgical Applications For Stem Cells. , Dr. Riordan ... and the properties of AlphaGEMS that include: wound ...
Breaking Biology Technology:Biocides Market for International & Chinese Regional Development Analysis Now Available at DeepResearchReports.com 2Biocides Market for International & Chinese Regional Development Analysis Now Available at DeepResearchReports.com 3Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 2Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 2Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 4Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 5Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 2Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 3Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 4
Cached News: