HOME >> BIOLOGY >> NEWS
Tips from the Journals of the American Society for Microbiology

Combined Immunization Methods May Offer Long-Term Protection Against H. pylori Infection

New immunization methods offer long-term protection against H. pylori in humans and may contribute to a possible ulcer vaccine in the future say researchers from the University of California, Davis. They report their findings in the July 2007 journal Infection and Immunity.

Helicobacter pylori is a bacterium that colonizes the digestive tract of 50% of the worlds population. Infection commonly occurs in early childhood and can lead to chronic gastritis, peptic ulcer disease and gastric cancer throughout the life of its host. Antibiotics are currently used against H. pylori infection, however increasing resistance as well as high treatment costs and recurrence of infection emphasize the need for an effective, long-lasting vaccine.

In the study mice were immunized in four groups: orally alone, intramuscularly alone, orally followed by intramuscularly, and intramuscularly followed by orally and then challenged orally with H. pylori after three months. Results showed that mice receiving intramuscular immunization alone or a combination of oral and intramuscular vaccinations had significantly reduced bacterial loads and no detectible H. pylori in the intestinal tract. Mice immunized orally alone or intramuscularly followed by orally were not protected and had decreased antibody responses.

This study demonstrates the ability to induce long-term immunity against H. pylori, provides correlates of protection, and illustrates the crucial role of the immunization route(s), say the researchers.

(J.M. Taylor, M.E. Ziman, J. Fong, J.V. Solnick, M. Vajdy. 2007. Possible correlates of long-term protection against Helicobacter pylori following systemic or combinations of mucosal and systemic immunizations. Infection and Immunity, 75. 7: 3462-3469).


New Ferret Model May Measure Pandemic Potential
'"/>

Contact: Carrie Patterson
cpatterson@asmusa.org
American Society for Microbiology
16-Jul-2007


Page: 1 2 3 4

Related biology news :

1. Tips from the Journals of the American Society for Microbiology
2. Tips from the Journals of the American Society for Microbiology
3. Tips from the Journals of the American Society for Microbiology
4. Tips from the Journals of the American Society for Microbiology
5. Tips from the Journals of the American Society for Microbiology
6. Tips from the Journals of the American Society for Microbiology
7. Tips from the Journals of the American Society for Microbiology
8. Oxford Journals release preliminary findings from open access experiments
9. Oxford Journals share evidence-based open access results with the community
10. Oxford Journals open access workshop
11. 1 in 8 of Thomson Scientifics 2005 Top 40 hottest papers from three Oxford Journals titles

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... (PRWEB) , ... August 20, 2020 , ... ... that Hassan Movahhed , a Clinical Operations executive with expertise in clinical ... has joined the firm as an Expert Consultant. Throughout his career, Mr. Movahhed ...
(Date:8/12/2020)... ... August 12, 2020 , ... Mosio recently ... ideal for public health agencies of all sizes. With a focus on tracking ... individuals find appropriate health care, Mosio helps public health departments automate communications and ...
(Date:8/7/2020)... ... August 06, 2020 , ... Nine middle school teachers from ... Program, a unique professional development program that provides advanced STEM (science, technology, engineering ... teachers nationwide. , Created in partnership between the National Stem Cell Foundation and ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... Ariz. (PRWEB) , ... July 29, 2020 , ... R3 ... joint injections for only $3950. With 50 million stem cells total, patients may choose ... stem cell therapy works for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, ...
(Date:7/31/2020)... CAMBRIDGE, Mass. and SOMERSET, N.J (PRWEB) , ... ... ... a leading genome editing company, and Catalent, the leading global provider of advanced ... and consumer health products, today announced that they have entered into a strategic ...
(Date:7/22/2020)... ... 22, 2020 , ... Join experts from Reed Tech , Gary Saner, ... a one hour live webinar on Thursday, August 13, 2020 at 11am ... and medical devices. Specifically, for medical devices, the NMPA has departments dealing with medical ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra , ... sciences and food industries, is pleased to announce that Charles Galea has joined ... Development. , Charles is an accomplished and results-driven sales executive with over 10 ...
Breaking Biology Technology:
Cached News: