Tissue engineered from fetal skin cells could treat paediatric burns

Swiss researchers have used skin constructed from fetal skin cells to treat eight children with burns, reporting their results in paper published online by THE LANCET today (Thursday August 18, 2005).

Skin grafting, where a patch of skin is surgically removed from one area of the body and transplanted to another one, is the gold standard for treatment of deep second and third degree burns. However, bioengineered skin products are also needed to facilitate this two-step surgical procedure.

Patrick Hohlfeld (University Hospital of Lausanne, Switzerland) and colleagues developed a bank of fetal skin cells from one 4cm2 donation of fetal skin. A woman whose pregnancy was terminated at 14-weeks gave written informed consent for doctors to take a skin biopsy from her fetus. The authors note that several million skin constructs (9 x12cm) suitable for therapeutic use could be produced from the single organ donation. The team recruited eight children with burns onto the study that were candidates for traditional skin grafting. The team placed fetal skin cell constructs on the children's lesions and bandaged them. They changed their dressings every 3-4 days for 3 weeks. The researchers found that all the children had their wounds closed at just over 2 weeks and no child needed traditional grafting because the fetal constructs closed their wounds alone.

Professor Hohlfeld concludes: "We have shown that fetal skin is a substitute for biological skin that can provide burned patients with a very high quality of skin in a short time with no additional grafting techniques In view of the therapeutic effects of this technique along with the simplicity in application, fetal skin cells could have great potential in tissue engineering."


Contact: Joe Santangelo

Page: 1

Related biology news :

1. Light-Activated Tissue Regeneration and Therapy -- II
2. Tissue geometry plays crucial role in breast cell invasion
3. Tissue microenvironment implicated in susceptibility to liver cancer metastases
4. Tissue stiffness drives tumor formation
5. Tissue rigidity promotes tumor progression
6. Tissue regeneration operates differently than expected
7. Scientists move closer to bio-engineered bladders
8. First all-African produced genetically engineered maize is resistant to maize streak virus
9. New study finds genetically engineered crops could play a role in sustainable agriculture
10. Adult stem cells from human cord umbilical cord blood successfully engineered to make insulin
11. Can engineered immune cells stop AIDS?

Post Your Comments:

(Date:4/6/2017)... 2017 Forecasts by Product Type ... by End-Use (Transportation & Logistics, Government & Public Sector, ... Fossil Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation ... Are you looking for a definitive report on the ... ...
(Date:4/3/2017)... 3, 2017  Data captured by IsoCode, ... detected a statistically significant association between the ... treatment and objective response of cancer patients ... predict whether cancer patients will respond to ... well as to improve both pre-infusion potency testing ...
(Date:3/28/2017)... 2017 The report "Video Surveillance ... Servers, Storage Devices), Software (Video Analytics, VMS), and Service ... Forecast to 2022", published by MarketsandMarkets, the market was ... projected to reach USD 75.64 Billion by 2022, at ... base year considered for the study is 2016 and ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ... and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... maternal age to IVF success. , After comparing the results from the fresh ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that give ... Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital Los Angeles ...
(Date:10/10/2017)... , Oct. 10, 2017 International research firm Parks ... Strategy, will speak at the TMA 2017 Annual Meeting , October ... trends in the residential home security market and how smart safety and ... Parks ... "The residential ...
(Date:10/10/2017)... ... 10, 2017 , ... The Pittcon Program Committee is pleased ... scientists who have made outstanding contributions to analytical chemistry and applied spectroscopy. Each ... leading conference and exposition for laboratory science, which will be held February 26-March ...
Breaking Biology Technology:
Cached News: