HOME >> BIOLOGY >> NEWS
Towards targeted lung cancer treatment

Better understanding of the mechanisms underlying cancer development has lead to the development of new anti-cancer drugs aimed at specific molecular targets. Because cancer is a heterogeneous disease, however, many of these new drugs work only in a subset of patients. They are also expensive, and they can have serious side effects. Scientists are therefore trying to find ways to predict who will benefit from a particular drug, so that they can better weigh the risks and benefits for an individual patient. In an article in the current issue of the international open-access medical journal PLoS Medicine, William Pao, Harold Varmus, and colleagues from Memorial Sloan Kettering Cancer Center in New York report results that might lead to more "targeted therapy" for lung cancer patients.

The researchers had previously shown that the epidermal growth factor (EGF) receptor, a tyrosine kinase, is often mutated in non-small-cell lung cancers, and that tumors that harbor such mutations are sensitive to two drugs called gefitinib and erlotinib. In the new study, they focused on a signaling protein called KRAS. The KRAS gene is also often mutated in lung cancers, but very few cancers have mutations in both the EGF receptor and the KRAS gene. The researchers found that those patients whose tumors had KRAS mutations had not shown an anti-tumor response when they were treated with either erlotinib or gefitinib.

These findings need to be validated by additional studies. If they are confirmed, it means that doctors should analyze tumors for mutations in the EGF receptor and KRAS before they decide whom to treat with erlotinib or gefitinib.


'"/>

Contact: Paul Ocampo
pocampo@plos.org
1-415-624-1224
Public Library of Science
24-Jan-2005


Page: 1

Related biology news :

1. Dengue and other hemorrhagic fevers: Towards a first potential treatment
2. Towards predicting late-stage radiation toxicity
3. Towards the mechanism of cell respiration
4. Towards a unified model of transcription termination
5. Towards a cheap and easy way to monitor HIV/AIDS
6. Genomic signatures identify targeted therapies for lung cancer
7. Nanocomposite labeled cancer cells can be targeted and destroyed using lasers
8. Progress toward a targeted therapy for a specific form of leukemia
9. NDDO and ESMO joined by US National Cancer Institute in conferences on targeted cancer therapies
10. Biomarkers of response to VEGF pathway-targeted therapy discovered for renal cell carcinoma
11. Light activated anticancer drug targeted to DNA using cisplatin like sub-units

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/25/2017)... YORK , Jan. 25, 2017 The ... Access Management (IAM) lifecycle is comprised of a ... for the purpose of maintaining digital identities and ... resources and applications. There are significant number of ... from time to time by optimizing processes and ...
(Date:1/21/2017)... Jan 20, 2017 Research and Markets has ... 2017-2021" report to their offering. ... The global voice recognition biometrics market to ... The report covers the present scenario and the growth ... calculate the market size, the report considers the revenue generated from ...
(Date:1/18/2017)... 2017 MedNet Solutions , an ... entire spectrum of clinical research, is proud to ... for the organization in terms of corporate growth, ... products and services. The company,s exceptional achievements can ... iMedNet ™ – ...
Breaking Biology News(10 mins):
(Date:2/20/2017)... 2017  This Report analyzes the worldwide markets for Bioinformatics in ... provides separate comprehensive analytics for the US, Canada ... Asia-Pacific , Latin America , ... http://www.reportlinker.com/p04707099-summary/view-report.html ... Annual estimates and forecasts are provided for the period 2015 ...
(Date:2/20/2017)... Philadelphia, PA (PRWEB) , ... ... ... technologies to improve therapeutic success among radiotherapy patients, prevent chest wall collapses ... for femur fracture alignments will receive a total of $600,000 in funding ...
(Date:2/19/2017)... ... February 19, 2017 , ... Expanding Portfolio to Include Lab ... equipment with the goal of expanding the reach of its quality and precision ... water analysis meters were introduced into the market in 2014. , The OHAUS ...
(Date:2/17/2017)... February 17, 2017 According ... by Product (Consumables, Service), Type (Safety, Efficacy, Validation), ... Drug Discovery and Development, Disease-Risk) - Global Forecast ... projected to reach USD 53.34 Billion by 2021 ... a CAGR of 13.8% during the forecast period ...
Breaking Biology Technology:
Cached News: