HOME >> BIOLOGY >> NEWS
Toxic milk

In the August 1 issue of G&D, Dr. Ronald Evans (Salk Institute) and colleagues report on their discovery that mutations in the mouse gene encoding PPAR adversely affect lactation milk quality, and have serious health consequences for nursing pups.

By examining PPAR functions in vivo, our work reveals an unexpected link between diet, inflammation and the quality of mothers milk, explained Dr. Evans.

PPAR (peroxisome proliferator-activator receptor gamma) is a nuclear receptor that is known to regulate metabolism and inflammation in various organisms. In fact, human PPAR is the main target of the drug class of thiazolidinediones (TZDs), which is used to manage diabetes.

Dr. Evans and colleagues sought to determine the role of PPAR in the lactating mammary gland. They generated a strain of mice that, as adults, lacked PPAR only in hematopoietic and endothelial cells. When these PPAR-deficient animals became mothers, they appeared normal, but the milk they produced most certainly was not.

"We were delighted and surprised by the discovery because it directly explores one of life's most common events - breast feeding. These findings will enhance the understanding of why milk is healthful and the molecular pathways that create the bodies own quality control pipe line," says Dr. Evans.

The researchers noticed that pups of the PPAR-deficient females who were, themselves, genetically normal - were displaying a number of abnormalities, most noticeably marked hair loss across their trunks and growth retardation. The scientists determined that these abnormalities were due to their ingestion of toxic milk from their PPAR-deficient mothers: Either fostering by PPAR-normal mothers or weaning to solid food effectively cured these small and balding pups.

Through a variety of experimental approaches, Dr. Evans and colleagues determined that PPAR loss results in increased levels of pro-inflammatory lipids being release
'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
23-Jul-2007


Page: 1 2

Related biology news :

1. USGS at Society of Environmental Toxicology and Chemistry
2. Toxic molecule may cause most common type of muscular dystrophy
3. Penn receives $4 million to establish a Center of Excellence in Environmental Toxicology
4. Toxic waves
5. Toxicology-on-a-chip tool readies for market
6. Researcher: Toxic flood lifts lid on common urban pollution problem
7. Toxic flame retardant accumulates in dolphins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/11/2020)... ... 2020 , ... Superior Controls, Inc. , an E Technologies Company and ... life sciences industry, is pleased to announce the recent hiring of Ray Boudreau, who ... New Hampshire office. In his new role, Boudreau will use his extensive experience ...
(Date:6/2/2020)... ... June 02, 2020 , ... ... and RFID labeling software developer and solutions provider, today reported that the ... labeling accuracy and compliance by 100%, resulting in greater efficiency for global ...
(Date:5/28/2020)... WILMINGTON, Del. (PRWEB) , ... ... ... & Biosciences (DuPont) has announced a new enzyme solution for adjunct liquefaction: ... distilleries alike including the ability to expand into new segments with locally-sourced ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... ... June 22, 2020 , ... Dracen ... will be presented June 22-24 during the American Association for Cancer Research Virtual ... other profiles the potent, consistent single agent activity in KEAP1 mutant tumor models ...
(Date:6/11/2020)... ... June 09, 2020 , ... TRX ... NEON Micro-Tracer Solution, a highly accurate, contact tracing solution for identification ... workplace. Contact tracing, a core disease control measure, is a key strategy for ...
(Date:5/30/2020)... ... May 29, 2020 , ... ... Officer 360°, the first newsletter solely dedicated to the unique role of the ... range of perspectives on the responsibilities, problem-solving, best practices and career development of ...
(Date:5/21/2020)... ... 19, 2020 , ... Experienced periodontist in Eden Prairie, MN, Dr. Andres Sanchez, ... through PIEZOSURGERY® technology. PIEZOSURGERY uses ultrasonic vibrations to gently cut bone in ... for dental implants, especially when the implants need to be placed in a sensitive ...
Breaking Biology Technology:
Cached News: