HOME >> BIOLOGY >> NEWS
Tracing Parkinson's lethal mechanism

In the vast majority of Parkinsons disease (PD) patients, the disorder arises not because of a genetic defect, but because some external insult triggers the death of dopamine-producing neurons. Now, researchers have reported progress in understanding the mechanism underlying that death, which they say suggests a new treatment pathway.

In both mice and human patients, the researchers have found evidence that neurons die because of a crippling of a particular protective enzyme that eliminates potentially damaging reactive oxygen species normally generated in the cells power plants, called mitochondria.

David Park, of the Ottawa Health Research Institute, and colleagues published their findings in the July 5, 2007 issue of the journal Neuron, published by Cell Press.

The researchers studied the mechanism of PD using a mouse model of the disease, in which a mitochondria-affecting toxin called MPTP is used to produce Parkinsons-like brain pathology. In earlier studies, they had found that MPTP activates protein-snipping enzymes called calpains in mitochondria. They also found evidence that calpains, in turn, activate a cellular switch called Cdk5. The question, however, was how this abnormal activation ultimately kills neurons.

In their new studies, the researchers analyzed neurons to determine that Cdk5 regulates yet another enzyme called Prx2. This enzyme is known as a peroxidase and acts to render harmless the chemically active reactive oxygen species that are produced inside mitochondria in the process of generating energy for the cell.

Specifically, the researchers found that treating neurons with MPTP activates Cdk5 to switch off Prx2. Whats more, they found that activating Prx2 in MPTP-treated mice prevented the loss of dopamine-producing neurons. And they experimentally demonstrated that the action of Cdk5 on Prx2 plays a pivotal role in the neuronal damage from MPTP.

Importantly, the researchers disc
'"/>

Contact: Erin Doonan
edoonan@cell.com
617-397-2802
Cell Press
5-Jul-2007


Page: 1 2

Related biology news :

1. Tracing the pathways of neurofibromatosis
2. Tracing the formation of long-term memory
3. The selfs broken border: Tracing the role of agency attribution in schizophrenia
4. Scientists identify 2 distinct Parkinsons networks
5. Lancet study shows gene therapy for Parkinsons disease is safe and some patients benefit
6. Gene therapy study shows safety and statistically significant improvement in Parkinsons disease
7. PINK1 protects from Parkinsons
8. Parkinsons protein protects neurons from stress induced cell death
9. UCLA researchers discover link between Parkinsons and narcolepsy
10. Alzheimers, Parkinsons, type 2 diabetes similar at molecular level
11. Nanotechnology offers hope for treating spinal cord injuries, diabetes and Parkinsons disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... September 03, 2020 , ... Brilliant , the ... System and its products are now available for purchase in the U.S., Canada, and ... security, AV, and low-voltage products. In addition to being available for purchase through ...
(Date:9/3/2020)... ... 03, 2020 , ... Litmus Health , the research-ready ... of the company’s security practices has been completed. The assessment deemed Litmus infrastructure ... evaluation reviewed Litmus’ processes and systems, assessing them to see whether they adhere ...
(Date:8/26/2020)... and SHANGHAI (PRWEB) , ... August 24, 2020 ... ... novel approaches for the treatment of chronic inflammatory and fibrotic diseases, today announced ... and Vice President of Drug Discovery. , Dr. Canan previously served as Executive ...
Breaking Biology News(10 mins):
(Date:9/3/2020)... Mo. (PRWEB) , ... September 03, 2020 , ... ... 2020, will feature 15+ expert speakers to present updates on their latest research ... highlight innovative technologies and their impact in clinical diagnostics and therapeutic development, as ...
(Date:9/1/2020)... , ... September 01, 2020 , ... ... sciences, biotechnology, and diagnostics companies, has announced the placement of Julianne Averill ... be responsible for leading all financial operations and implementing key business strategies to ...
(Date:8/31/2020)... ... 2020 , ... DuPont Nutrition & Biosciences announced today the ... plant operation will provide the local animal production industry with customized solutions according ... improve the flexibility of our offerings to the Chinese animal nutrition market,” said ...
(Date:8/15/2020)... , ... August 13, 2020 , ... True Terpenes ... creation of its Scientific Advisory Board (SAB) to research the medical potential of terpenes ... be enhanced when combined with terpenes. The board is focused on expanding the recently ...
Breaking Biology Technology:
Cached News: