HOME >> BIOLOGY >> NEWS
Treatment-induced growth factor causes cancer progression

In advanced cancer, anti-tumor therapies often work only partially or not at all, and tumors progress following treatment.

Vanderbilt-Ingram Cancer Center scientists have now linked a treatment-induced growth factor to the cancers future spread.

The team led by Carlos Arteaga, M.D., reports in the May issue of the Journal of Clinical Investigation that radiation and chemotherapy increase circulating levels of the growth factor TGF-beta, circulating cancer cells, and tumor metastases in a mouse model of metastatic breast cancer.

Blocking TGF-beta in the model prevented tumor metastases, suggesting that TGF-beta inhibitors may be clinically useful in combination with primary therapies.

Arteaga and colleagues had previously shown that a brief induction of TGF-beta in a transgenic mouse model of breast cancer dramatically accelerated metastasis.

Then they came across a few clinical studies showing that radiation and chemotherapy increase TGF-beta in patients or in experimental tumors.

"We wondered then if TGF-beta induced by anti-cancer therapies can serve as a survival signal for tumor cells, thus allowing them to withstand therapy and later recur," said Arteaga, professor of Medicine and Cancer Biology and director of the Vanderbilt-Ingram Breast Cancer Program.

This appears to be the case, he said. Radiation therapy and the chemotherapeutic agents doxorubicin and docetaxel all increased TGF-beta levels and accelerated metastasis, an effect that was blocked by neutralizing antibodies directed against TGF-beta.

Similar results not reported in this paper have been observed with small molecule inhibitors of the TGF-beta type I receptor kinase.

"We speculate, based on these observations, that this will occur in some patients," Arteaga said.

Patients who have treatment-induced increases in TGF-beta may not respond as well to the anti-cancer therapy as those who do n
'"/>

Contact: Heather Newman
heather.newman@vanderbilt.edu
615-936-7245
Vanderbilt University Medical Center
5-Apr-2007


Page: 1 2

Related biology news :

1. Circadian clock controls plant growth hormone
2. Defects in critical gene lead to accelerated lung tumor growth
3. Chickadee, nutchatch presence in conifers increases tree growth, says CU-Boulder study
4. Steroids, not songs, spur growth of brain regions in sparrows
5. A new method of adult stem cell growth efficacious in treatment of disorders of the cornea
6. Antibody retards growth and induces death in liver cancer cells
7. Internal clock, external light regulate plant growth
8. Satellite images reveal link between urban growth and changing rainfall patterns
9. Getting to the root of plant growth
10. Mathematics reveals genetic pattern of tumor growth
11. CSHL scientists successfully target tumor microenvironment to stop cancer growth

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2019)... ... 2019 , ... Boston-based Laboratory as a Service (LaaS) leader, Mass Innovation Labs, ... its continued expansion and service offerings for biotech and life sciences companies. ... that is more agile and adaptable than ever before. One that doubles-down on the ...
(Date:1/10/2019)... ... January 10, 2019 , ... A major goal ... in vitro studies and significantly more expensive in vivo studies in order to ... To address this need, researchers have begun to adopt 3D cell culture models ...
(Date:1/7/2019)... (PRWEB) , ... January 07, 2019 , ... ... (AI) and leading supplier of Graph Database technology for Knowledge Graphs solutions, announced ... a 2019 ‘Trend-Setting’ Product . DBTA’s data and information management recognition ...
Breaking Biology News(10 mins):
(Date:1/10/2019)... ... 2019 , ... Rascal was adopted from a local shelter when he was around two years ... Unfortunately, just six weeks after he was adopted, he tore his right cruciate ligament. ... the joint after such a traumatic injury. , Sure enough, when Rascal was about nine ...
(Date:1/10/2019)... ... January 08, 2019 , ... VGI Medical was founded ... a leader in bringing innovation to the market including VerteLoc, CerLoc, SiJoin and VerteLP. ... joint by utilizing a unique patented dual geometric design to limit motion of the ...
(Date:1/8/2019)... MILWAUKEE (PRWEB) , ... January 08, 2019 , ... The ... career development grant recipients were named by a selection committee made up of industry ... $245,000. , The Career Development grants are mentored awards created to support ASGCT members ...
(Date:1/4/2019)... ... January 04, 2019 , ... Triangle ... Hoffman to the firm. Ted will be joining the firm as a partner. ... providing consulting services to the pharmaceutical industry. At Triangle Insights, Ted will apply ...
Breaking Biology Technology:
Cached News: