HOME >> BIOLOGY >> NEWS
Treatment-induced growth factor causes cancer progression

In advanced cancer, anti-tumor therapies often work only partially or not at all, and tumors progress following treatment.

Vanderbilt-Ingram Cancer Center scientists have now linked a treatment-induced growth factor to the cancers future spread.

The team led by Carlos Arteaga, M.D., reports in the May issue of the Journal of Clinical Investigation that radiation and chemotherapy increase circulating levels of the growth factor TGF-beta, circulating cancer cells, and tumor metastases in a mouse model of metastatic breast cancer.

Blocking TGF-beta in the model prevented tumor metastases, suggesting that TGF-beta inhibitors may be clinically useful in combination with primary therapies.

Arteaga and colleagues had previously shown that a brief induction of TGF-beta in a transgenic mouse model of breast cancer dramatically accelerated metastasis.

Then they came across a few clinical studies showing that radiation and chemotherapy increase TGF-beta in patients or in experimental tumors.

"We wondered then if TGF-beta induced by anti-cancer therapies can serve as a survival signal for tumor cells, thus allowing them to withstand therapy and later recur," said Arteaga, professor of Medicine and Cancer Biology and director of the Vanderbilt-Ingram Breast Cancer Program.

This appears to be the case, he said. Radiation therapy and the chemotherapeutic agents doxorubicin and docetaxel all increased TGF-beta levels and accelerated metastasis, an effect that was blocked by neutralizing antibodies directed against TGF-beta.

Similar results not reported in this paper have been observed with small molecule inhibitors of the TGF-beta type I receptor kinase.

"We speculate, based on these observations, that this will occur in some patients," Arteaga said.

Patients who have treatment-induced increases in TGF-beta may not respond as well to the anti-cancer therapy as those who do n
'"/>

Contact: Heather Newman
heather.newman@vanderbilt.edu
615-936-7245
Vanderbilt University Medical Center
5-Apr-2007


Page: 1 2

Related biology news :

1. Circadian clock controls plant growth hormone
2. Defects in critical gene lead to accelerated lung tumor growth
3. Chickadee, nutchatch presence in conifers increases tree growth, says CU-Boulder study
4. Steroids, not songs, spur growth of brain regions in sparrows
5. A new method of adult stem cell growth efficacious in treatment of disorders of the cornea
6. Antibody retards growth and induces death in liver cancer cells
7. Internal clock, external light regulate plant growth
8. Satellite images reveal link between urban growth and changing rainfall patterns
9. Getting to the root of plant growth
10. Mathematics reveals genetic pattern of tumor growth
11. CSHL scientists successfully target tumor microenvironment to stop cancer growth

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/5/2020)... ... 2020 , ... With numerous products in its pipeline, Cytonus ... Cytonus’ existing products and to expand the companies’ intellectual property assets. Cytonus is ... located in Austria. , Phoenestra has developed IP assets in connection with ...
(Date:3/5/2020)... ... March 05, 2020 , ... Diagenode, a leading ... Tech (MGI), a subsidiary of global genomics leader BGI Group, today announced a ... States, Europe and Asia Pacific. , Under the terms of the non-exclusive ...
(Date:3/4/2020)... ... March 04, 2020 , ... The Massachusetts Medical Device Industry ... IGNITE program’s 2020 IGNITE Cohort. The MedTech IGNITE Program is a virtual accelerator ... next generation of medtech founders and entrepreneurs. IGNITE Cohort members get access to ...
Breaking Biology News(10 mins):
(Date:3/4/2020)... ... March 04, 2020 , ... This month, Cognosante will ... FL. The company will showcase both expanded and emerging offerings that align with the ... is designed to be comprehensive, timely, and engaging. From Interoperability and ...
(Date:2/28/2020)... ... February 26, 2020 , ... Designed primarily ... camera with a dedicated controller, thus simplifying setup, streamlining integration, and optimizing workflow. ... the first of Fastec Imaging’s new HS Series cameras to be released. The ...
(Date:2/21/2020)... ... February 20, 2020 , ... ... chain transparency and reassuring consumers that what’s listed on an ingredient panel is ... Nutrition21 has introduced this solution with the adoption of CertainT, which is designed ...
(Date:2/19/2020)... (PRWEB) , ... February 18, 2020 , ... ... medical devices, today announced the launch of a new and unified global brand ... tackle the industry’s most complex engineering challenges, as well as an enthusiasm for ...
Breaking Biology Technology:
Cached News: