HOME >> BIOLOGY >> NEWS
Treatments for urinary infections leave bacteria bald, happy and vulnerable

A different approach to treating urinary tract infections (UTIs) could defeat the bacteria that cause the infections without directly killing them, a strategy that could help slow the growth of antibiotic-resistant infections.

Instead of trying to wipe out bacteria, researchers in the laboratory of Scott Hultgren, Ph.D., the Helen L. Stoever Professor of Molecular Microbiology at Washington University School of Medicine in St. Louis, have been working to create pharmaceuticals that essentially "defang" the bacteria by preventing them from assembling pili, microscopic hairs that both enable the invasion of host cells and allow the bacteria to mount a cooperative defense against the host's immune system.

"We're leaving the bacteria bald but healthy and happy," says Jerome S. Pinkner, lab manager for Hultgren. "Rather than trying to kill them, we're working to make them non-pathogenic, so that they will be unable to adhere to or invade the bladder tissues and are readily eliminated from the body."

Pinkner and his colleagues think the bacteria will find it harder to evolve resistance to a treatment that does not directly impact their survival. According to an April 2006 National Institute of Allergy and Infectious Diseases fact sheet, resistance to at least one antibiotic has been detected in more than 70 percent of the bacteria that cause hospital-acquired infections.

In a recent paper in the Proceedings of the National Academy of Sciences, the Hultgren group and its collaborators reported on the successful development of a second generation of anti-pilus treatments or pilicides. A third generation is already undergoing tests now, and researchers are hoping to begin tests of their most potent pilicides in animal models in about a year.

UTIs mainly occur in women and are one of the most common infections, causing around $1.6 billion in medical expenses every year in the United States. Scientists believe 90 percent of all U
'"/>

Contact: Michael Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
20-Dec-2006


Page: 1 2 3

Related biology news :

1. Treatments have same target, different responses for lung cancer patients with genetic mutation
2. Attack is the best defence against urinary tract infection
3. Injecting stem cells from a womans own muscle may effectively treat urinary incontinence
4. Study demonstrates rapid diagnosis of urinary tract infections with biosensor technology
5. Progress toward a new remedy for chronic urinary tract infections?
6. UCSB researchers advance understanding of urinary tract infections
7. Bugs-eye-view of urinary tract reveals E.coli infection genes
8. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
9. Injection drug use and HIV and HCV infections among Ontario prison inmates
10. Injection drug use the most important risk factor for HIV and HCV infections among Quebec prisoners
11. Mucins stand guard against gut infections

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/5/2020)... ... 2020 , ... Diagenode, a leading global provider of complete ... of global genomics leader BGI Group, today announced a co-marketing agreement for Diagenode’s ... Pacific. , Under the terms of the non-exclusive agreement, the two companies ...
(Date:3/4/2020)... ... March 04, 2020 , ... RoosterBio ... and hMSC bioprocess systems, announces today a significant milestone in the regenerative medicine ... materials. The patient has been treated by RoosterBio’s pharmaceutical customer with an Investigational ...
(Date:3/2/2020)... ... March 02, 2020 , ... Nominations are now being ... by the Security Industry Association (SIA) and SecureIDNews and co-presented ... in Security Forum . The recipients of this year’s Women in Biometrics Awards will ...
Breaking Biology News(10 mins):
(Date:3/3/2020)... ... 03, 2020 , ... Frictionless Solutions, a specialized event services ... recognized by INC. 5,000 on an annual list of America’s fastest growing private ... impacting their spheres of influence and experiencing considerable development. INC. 5,000’s specific list ...
(Date:2/26/2020)... ... February 25, 2020 , ... Continuing its leading research on ... of its safety assessment on the biotechnologically produced 3-Fucolsyllactose (3-FL) HMO. , ... complex carbohydrates are indigestible and therefore function as a prebiotic by promoting early ...
(Date:2/21/2020)... ... February 21, 2020 , ... Join Forrest Brown, Engineering Services Manager – Northeast ... for an informative session on Wednesday, February 26, 2020 at 1pm ... incorporate into facility design to add manufacturing flexibility in the future, especially for CMOs ...
(Date:2/19/2020)... (PRWEB) , ... February 19, 2020 , ... ... process solutions for the life sciences industry, today announced the opening of a ... Nagamura, Associate Partner, Red Nucleus R&D. , Red Nucleus announced the new office ...
Breaking Biology Technology:
Cached News: