HOME >> BIOLOGY >> NEWS
Trio of leukemias share a single mutation

" said Gilliland. "We thought it was a good bet that the cause would be a constitutively activated tyrosine kinase." According to Gilliland, while PV, ET and MMM are rare, their prevalence is about five times higher than CML, with about 100,000 cases in the U.S. each year.

The researchers performed high-throughput DNA sequence analysis of blood and mouth-swab samples from 164 PV patients, 115 ET patients and 46 MMM patients. The patients were recruited via a notice posted on the web site of an advocacy group for people with myeloproliferative disease. The researchers used a sequencing technique developed in collaboration with co-authors William Sellers and Matthew Myerson of Dana-Farber. Specifically, they sequenced regions of tyrosine kinases that were likely to be mutated in the leukemias.

Their sequencing analysis revealed that about 75 percent of the PV patients, 32 percent of the ET patients and 35 percent of the MMM patients showed the same defect in the gene for a tyrosine kinase known as JAK2.

"There are some similarities among these three different diseases, and some overlap in the diagnostic criteria, but it was a surprise to us that the same mutation appears to account for at least a fraction of cases for all three," said Gilliland

By comparing the DNA sequences from the blood with those from the mouth swabs, the researchers could determine which mutations the blood cell progenitors had acquired -- since the mouth-swab DNA represents inherited germline DNA that had not undergone mutation. Their comparisons revealed that the characteristic mutation in JAK2 was acquired, not inherited. And since the researchers did not find the mutation in a large number of normal blood samples, they were able to conclude that the mutation was characteristic of a large fraction of the three leukemias.

JAK2 normally functions as a molecular switch to trigger proliferation of red blood cells in response to events such as blood loss, said Gilliland. Al
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
24-Mar-2005


Page: 1 2 3 4

Related biology news :

1. Researchers discover a stem-cell switch lurking within leukemias
2. 20 Kentucky firms share $1.9 million from state to match federal SBIR-STTR awards
3. Where is the proton? Yale scientists discover footprints of shared protons
4. Scripps research study shows humans and plants share common regulatory pathway
5. Genes and groups of genes commonly shared between species, studies show
6. Family members with MS likely to share onset age, but not disease severity
7. Public shares views on environmental, health and safety research needs for nanoscale materials
8. Green plants share bacterial toxin
9. American Andrew Z. Fire shares Nobel Prize for discovering RNAi
10. Telomere expert Carol Greider shares 2006 Albert Lasker Award for Basic Medical Research
11. Ocean seep mollusks may share evolutionary history with other deep-sea creatures

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2020)... (PRWEB) , ... August 06, 2020 , ... ... to participate in the prestigious National STEM Scholar Program, a unique professional development ... building, and project support for middle school science teachers nationwide. , Created in ...
(Date:7/31/2020)... ... July 30, 2020 , ... BioFactura, Inc. today ... by the Joint Science & Technology Office—Chemical and Biological Defense (JSTO-CBD) of the ... and scale-up a highly efficient mammalian cell culture-based bioprocess suitable to meet surge ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... effectiveness of the Invictus Medical Neoasis™ active noise control device to attenuate typical ... that the Neoasis™ device attenuated the alarm sounds from patient monitors, ventilators and ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 30, 2020 , ... ... for the life sciences industry, today announced the release of its signature ... for Medical Science Liaisons (MSLs) and other field medical professionals. , ...
(Date:7/18/2020)... ... ... After research model surgery and catheter implantation, the long journey of catheter maintenance ... a successful study, while protecting and accessing the catheter or device post-surgery is often ... Envigo in a live webinar on Wednesday, August 5, 2020 ...
(Date:7/18/2020)... ... July 16, 2020 , ... Medial EarlySign , ... and prevention of high-burden diseases, and Centric Consulting, a business and technology consulting ... utilize existing data in order to identify and prioritize patients for care. , ...
(Date:7/10/2020)... ... July 08, 2020 , ... Bode ... significant expansion of laboratory operations through its COVID-19 testing service, Bode-CARES . ... , Bode-CARES provides a turnkey solution that includes a comprehensive ...
Breaking Biology Technology:
Cached News: