HOME >> BIOLOGY >> NEWS
Triptolide: A potential drug for polycystic kidney disease

rmed, as sensed by fluid flow in the tubule. Fluid flow bends the primary cilium, giving a signal to stop cell growth. PKD is caused by a mutation in the PKD1 or PKD2 gene causing the cells to miss the stop growing signal, allowing them to keep growing, and thus generating a cyst.

In collaboration with Stefan Somlo, M.D., Chief of Nephrology at Yale School of Medicine, who discovered the PKD2 gene, triptolide was tested in a mouse model of PKD. Both fewer and smaller kidney cysts formed in mice lacking PKD1 when they were treated with therapeutic amounts of triptolide.

Our research shows that triptolide, an active ingredient of the TCM Lei Gong Teng, markedly decreases cyst formation in a mouse model of this most common genetic lethal kidney disease, Crews said. Our results offer a novel therapeutic approach to this deadly disease and highlight the potential of TCM as pharmaceutical sources.


'"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
5-Mar-2007


Page: 1 2

Related biology news :

1. UCF research links proteins, stem cells and potential Alzheimers treatment
2. Picky eating potentially perilous for bats
3. Scientists take next step in understanding potential target for ovarian cancer treatment
4. Nanoparticles hitchhike on red blood cells: a potential new method for drug delivery
5. Weill Cornell team identifies potential new cancer drug target
6. LIAI researchers identify a potential role for retinoic acid in autoimmune and inflammatory diseases
7. GM field trials underestimate potential for cross-pollination
8. New study suggests potential for a broadly-protective HIV vaccine
9. Hamilton College researchers discover molecules with potential to treat breast cancer
10. 8 plants from South Africa may hold potential for treating high blood pressure
11. TXNIP -- regulator of glucose homeostasis and potential diabetes drug target and more

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/18/2017)... Minn. , Jan. 18, 2017 ... technology company that supports the entire spectrum of ... has been another record-breaking year for the organization ... market interest in MedNet,s eClinical products and services. ... the tremendous marketplace success of iMedNet ...
(Date:1/12/2017)... 2017  Trovagene, Inc. (NASDAQ: TROV ), ... announced that it has signed agreements with seven strategic ... Middle East for commercialization of ... first wave of international distribution agreements for Trovagene,s CLIA ... The initial partners will introduce Trovagene,s liquid ...
(Date:1/12/2017)... and PUNE, India , January 12, 2017 ... Opportunities and Forecasts, 2015 - 2022," projects that the global biometric technology market is ... 19.4% from 2016 to 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:1/24/2017)... ... January 23, 2017 , ... Oklahoma City based Sigma Blood Systems has established ... PERFEQTA software and legacy product QC Manager 2.0. , Sigma Blood Systems CEO, ... and thrilled that they have decided to implement PERFEQTA and QC Manager 2.0, with ...
(Date:1/24/2017)... , January 23, 2017 According ... Market by Type (Genetic, Cell-based (CD34, PBMC, BLT)), Application ... User (Pharmaceutical & Biotech Companies, CRO) - Global Forecast ... global Humanized Mouse Model Market for the forecast period ... reach USD 116.0 Million by 2021 from USD 73.3 ...
(Date:1/24/2017)... Jan. 23, 2017  Today, the Fisher Center for ... funded an important study that could lead to the ... of Alzheimer,s disease. This groundbreaking research was conducted by ... by Nobel Laureate Dr. Paul Greengard , in ... Fisher Center scientists have linked a mutation ...
(Date:1/23/2017)... Fl (PRWEB) , ... January 23, 2017 , ... ... venture-backed teleradiology and telemedicine company announces significant growth last year adding 65 new ... Veterans Authority and US Army medical centers as well as one of US ...
Breaking Biology Technology:
Cached News: