"This project has importance for the public health and also for biodefense, because these viruses are potential bioterror agents," says Garry, professor of microbiology and immunology at the Tulane University School of Medicine.
In the first project of its kind, Garry will lead the effort to develop tests that would not require biosafety level 4 (the highest level) laboratories, the requirement for tests currently available.
Hemorrhagic fevers begin with fever and muscle aches, then may worsen until the patient becomes very ill with severe bleeding (hemorrhage), lung or kidney problems, and shock.
Lassa fever is an acute viral illness that occurs in West Africa, where it is a significant cause of sickness and death. The virus, a member of the virus family called arena viruses, is a single-stranded RNA virus that is spread by rats. Between 15 20 percent of patients hospitalized for Lassa fever die from the illness. Occasionally epidemics of Lassa fever break out, during which the death rate can reach 50 percent. The number of Lassa virus infections per year in West Africa is estimated at 100,000 to 300,000, with approximately 5,000 deaths. Of people admitted to hospitals in West Africa, 10 16 percent have Lassa fever, which indicates the serious impact of the disease on the population of this region.
"It's important that we develop better diagnostic tests because the main symptom initially is fever and that could be so many different diseases and
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Contact: Fran Simon
fsimon@tulane.edu
1-504-858-3833
Tulane University
27-Oct-2005