Tumor-free breast tissue can have precancerous changes

COLUMBUS , Ohio A new study using mastectomy tissue shows that precancerous changes can occur in normal-appearing areas of the breast as distant as two inches from a tumor's edge.

The findings, while preliminary, might have important implications for identifying breast-cancer patients at high risk of a second tumor in the same breast.

Researchers looked for and found a chemical change called DNA methylation in healthy tissue adjacent to breast tumors.

They measured this chemical change in a gene that often becomes highly methylated in breast cancer. The gene, called RASSF1A, is a tumor-suppressor gene. Tumor-suppressor genes normally protect cells from becoming cancerous, but the gradual silencing of these genes by abnormal methylation is thought to be an early change in cancer development.

In addition, the study identified three other genes that were abnormally methylated in both tumor and normal tissues.

The study, led by researchers at the Ohio State University Comprehensive Cancer Center James Cancer Hospital and Solove Research Institute and at H. Lee Moffitt Cancer Center and Research Institute, is published in a recent issue of the journal Clinical Cancer Research.

"This is evidence that DNA methylation is a very early event in tumor development, and that genes that are methylated might serve as useful markers for early cancer detection and diagnosis," says principal investigator Tim H-M. Huang, professor of molecular virology, immunology and medical genetics with Ohio State's Comprehensive Cancer Center.

"Our study might also help explain why, in the absence of radiation therapy, breast cancer often recurs near the site of the original tumor following a lumpectomy," says first author Pearlly S. Yan, research assistant professor of molecular virology, immunology and medical genetics and a researcher and a researcher in Huang's laboratory. Lumpectomy is a surgical procedure in which o

Contact: Darrell E. Ward
Ohio State University

Page: 1 2 3

Related biology news :

1. Newly created cancer stem cells could aid breast cancer research
2. New study suggests Concord grape juice may provide protection against breast cancer
3. U-M researchers identify gene involved in breast cancer
4. Additional mammogram readers improve breast cancer detection
5. Study finds Western-style meat-sweet diet increases risk of breast cancer in postmenopausal women
6. Link between immune system and mammary gland could shed new light on breast cancer
7. Sentinel lymph node biopsy is associated with breast cancer rates
8. Pregnancy nausea/vomiting may indicate lower risk of breast cancer
9. Scripps research scientists show protein accelerates breast cancer progression in animal models
10. Screening approach leads to discovery of gene linked to breast cancer
11. Scientists develop new drugs to fight colon and breast cancer more effectively

Post Your Comments:

(Date:8/21/2020)... , ... August 19, 2020 , ... ... LLC and SalivaBio LLC, businesses dedicated to Salivary Bioscience for more than twenty ... recently published book by Springer, " Salivary Bioscience: Foundations of Interdisciplinary Saliva Research ...
(Date:8/12/2020)... ... August 11, 2020 , ... Both Roche, based in Basel, ... license agreements with Housey Pharma’s HMI subsidiary to gain access to its core-enabling ... Research and Development spending in excess of US $10 billion. , Scientists at ...
(Date:8/7/2020)... ... August 06, 2020 , ... ... the prestigious National STEM Scholar Program, a unique professional development program that provides ... support for middle school science teachers nationwide. , Created in partnership between the ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... , ... ERT, the global leader in clinical ... one of the 100 most inspiring individuals in the life-sciences industry by PharmaVoice. ... on how they have inspired their colleagues and affected positive changes in their ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... launch of its new tagline, “BUILDING FOR LIFE.” The adoption of this taglines ... the globe, requiring fast track capacity to provide patients with urgently needed vaccines ...
(Date:7/31/2020)... ... July 29, 2020 , ... Editas ... global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, ... entered into a strategic partnership whereby Catalent will provide support for the development, ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... the life sciences industry, today announced the release of its signature product ... Medical Science Liaisons (MSLs) and other field medical professionals. , Beacon ...
Breaking Biology Technology:
Cached News: