HOME >> BIOLOGY >> NEWS
Tumor individuality useful for guiding rational chemotherapeutic decisions

A new study describes in detail exactly how the chemotherapeutic drug paclitaxel induces cell death in tumor cells and how common mutations in human tumors confer drug resistance, and demonstrates that combination treatment can restore therapeutic effectiveness of the drug. The research is published in the March issue of the journal Cancer Cell.

When damaged or stressed, normal cells die via a carefully controlled process called apoptosis. In contrast, cancer cells keep dividing, often due to genetic errors that disrupt the mechanisms required to induce apoptosis. Dr. Eileen White from Rutgers University and colleagues examined the role of a molecule called BIM in tumorigenesis and chemotherapeutic response to paclitaxel, a drug that has been used successfully to treat breast, prostate, ovarian, and lung cancers. The researchers examined BIM because it has been implicated as a tumor suppressor and is known to play a role in the regulation of apoptosis.

The researchers found that BIM accumulation is absolutely required for paclitaxel-induced apoptosis, and that BIM deficiency is associated with paclitaxel-resistant tumors. Further research revealed that the H-ras/MAPK signaling pathway suppresses paclitaxel-mediated BIM induction by causing BIM to be targeted for destruction in proteosomes, thereby blocking the ability of BIM to induce apoptosis. Importantly, cotreatment with paclitaxel and a proteosome inhibitor currently approved for use in clinical trials restored paclitaxel-stimulated BIM accumulation and apoptosis that enabled tumor regression.

The H-ras/MAPK pathway is intimately linked to promotion of cell survival and is often abnormally activated during tumorigenesis. The researchers conclude that combinatorial chemotherapy using proteosome inhibitors to enhance chemosensitivity to paclitaxel in tumors where the H-ras/MAPK pathway is activated may be therapeutically beneficial.

These results suggest that a clear underst
'"/>

Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2879
Cell Press
14-Mar-2005


Page: 1 2

Related biology news :

1. Tumor painting revolutionizes fight against cancer
2. Tumor vessels identified by unique molecular markers
3. Tumors stopped from spreading to new sites
4. Chest Tumors -- Prevention, treatment and future perspectives
5. Tumor cells evade death through autophagy
6. Tumor-free breast tissue can have precancerous changes
7. Tumor-suppressor gene is critical for placenta development
8. Tumor response may not be best measure of efficacy in non-small cell lung cancer treatment
9. Tumor cells that border normal tissue are told to leave
10. Tumor suppressor activity of PTEN
11. Scientists seek useful traits in wild cottons

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 25, 2020 , ... ... solutions for drugs, biologics, cell and gene therapies, and consumer health products, today ... PEGS Boston Virtual Conference & Expo, taking place between Aug. 31 – September ...
(Date:8/21/2020)... ... August 19, 2020 , ... “How can we ... dedicated to Salivary Bioscience for more than twenty years. Together with Douglas Granger, ... " Salivary Bioscience: Foundations of Interdisciplinary Saliva Research and Applications ," and Steven ...
(Date:8/12/2020)... , ... August 12, 2020 , ... ... monitoring systems that are ideal for public health agencies of all sizes. With ... diseases and helping at-risk individuals find appropriate health care, Mosio helps public health ...
Breaking Biology News(10 mins):
(Date:8/31/2020)... ... 2020 , ... DuPont Nutrition & Biosciences announced today the ... plant operation will provide the local animal production industry with customized solutions according ... improve the flexibility of our offerings to the Chinese animal nutrition market,” said ...
(Date:8/15/2020)... ... 2020 , ... Inc. magazine today revealed that Skysis is ... the nation’s fastest-growing private companies. The list represents a unique look at the ... Intuit, Zappos, Under Armour, Microsoft, Patagonia, and many other well-known names gained their ...
(Date:8/12/2020)... (PRWEB) , ... August 11, ... ... a biopharmaceutical cold chain validation engineering firm, is making available for free ... the need to incorporate concurrent transport simulation testing into today’s biologics licensing ...
(Date:8/7/2020)... ... August 06, 2020 , ... VGXI, a highly regarded ... on the purchase of greenfield for a new, expanded manufacturing facility. The site ... acres in the initial acquisition, with an option to purchase an additional 21 ...
Breaking Biology Technology:
Cached News: