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Tumor vessels identified by unique molecular markers

so report that in many of the tumors examined CD276 was also overexpressed by the tumor cells, making this protein a particularly attractive target because a suitable inhibitory molecule might be able to deliver a double blow: one to the tumor cells themselves and the other to the blood vessels that feed it. These studies reveal that tumor vessels contain a unique molecular fingerprint that can be used to distinguish them from normal proliferating vessels, explained Dr. St. Croix; they also provide new targets that could help guide the development of safer vascular-targeted therapies with potentially fewer side effects.


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Contact: Erin Doonan
edoonan@cell.com
617-397-2802
Cell Press
11-Jun-2007


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