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Two national diabetes-related initiatives coordinated by MCG bioinformatics expert

make it happen, he says. Scientists who receive funding agree to make their development data and resulting animal models available to the scientific community.

In 2001, while on the University of Florida faculty, Dr. McIndoe received the first grant to provide administrative and coordinating activities for investigators working on model development. Work includes organizing semi-annual Executive Steering Committee meetings, monthly teleconferences, workshops and training sessions and organizing activities for the External Advisory Boards.

A major task was developing a computer system that could take the huge amount of data generated by investigators, store it, analyze it in a flexible way and enable scientists all over the world to access it through a Web portal, www.amdcc.org.

"We have to have a way of storing and capturing all that information in an efficient way so another researcher can go back and do the same experiment or analyze it in real time," Dr. McIndoe says. "You also need to store information in a way that is very flexible so they can grab the information any way they want. We are constantly adding statistical analysis so data can be analyzed quicker."

To date, about 70 animal models have been studied, information on about 25 has been deposited in the database Dr. McIndoe developed and about 20 of those models will soon be available for ordering from mouse repositories. Interestingly, there is not necessarily a definitive model for even a single complication, rather an array of models will be necessary as researchers manipulate genes to try and mimic human disease. "They don't want an animal model that looks like a mouse problem; they want an animal model that looks like a human problem," he says.

As NIH looked at a second round of funding for the consortium, it took a fresh approach with each investigator proposing two new models and turning them over to a husbandry
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Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
26-Oct-2006


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