Two national diabetes-related initiatives coordinated by MCG bioinformatics expert

core for development. "Once created, the models will be sent back to the investigators who will be in charge of understanding the pathology of the complications," says Dr. McIndoe, noting the operational changes reflect the complexity and magnitude of the work.

NIH also opted to integrate operation of the consortium with the Mouse Metabolic Phenotyping Centers, which also were up for grant renewal. The centers' first round of funding didn't include money for administration and bioinformatics, but it was quickly determined both were needed.

"The centers bring to the general scientific community a low-cost way of doing a variety of metabolic assays on mice that would be cost-prohibitive to set up in your local lab," he says. "For example, if you don't have a small-animal MRI unit on your campus, there is no way you can do some of these assays." For a small fee, centers will characterize mouse metabolism, blood components including hormones, energy balance, eating and exercise, organ function and form, physiology and histology. For more information about services and fees, visit www.mmpc.org.

The University of Cincinnati, Vanderbilt University and the University of Washington have been designated as Mouse Metabolic Phenotyping Centers. Additional centers are being solicited through the Coordinating and Bioinformatics Unit at MCG and will be funded through a subcontract with MCG, Dr. McIndoe says.

The Animal Models of Diabetic Complications Consortium and the Mouse Metabolic Phenotyping Centers will continue to function autonomously. But Dr. McIndoe has gutted the infrastructure he created for the AMDCC to accommodate the workings of both. "The face of it will be individual, but the underlying software architecturally works together."

"This grant, the largest award ever received by MCG, is on target with the NIH's initiatives to accelerate translation of scientific discoveries into imp

Contact: Toni Baker
Medical College of Georgia

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