HOME >> BIOLOGY >> NEWS
U-M researcher examines the cell's housekeeping habits

ANN ARBOR, Mich---The cells of higher organisms have an internal mechanism for chewing up and recycling parts of themselves, particularly in times of stress, like starvation and disease. But nobody is quite sure yet whether this recently discovered process protects cells, or causes damage.

This process of internal house-cleaning in the cell is called autophagy literally self-eating and it is now considered the second form of programmed cell death (PCD). Apoptosis, the first kind of programmed cell death to be characterized, is now also known as Type I PCD.

Genes governing Type II PCD, autophagy, have been identified recently in many species, starting with baker's yeast, and some of the environmental triggers that start the process are being found. But there is still quite a bit of science to do before autophagy can be understood as either a good thing or a bad thing. The evidence points both ways.

"It's likely to be both, depending on when it happens," said Daniel Klionsky, a research professor at the University of Michigan Life Sciences Instituteand professor of molecular cellular and developmental biology and biological chemistry.

Klionsky, who has been studying autophagy in yeast, has written a review article on the latest work in the field with post-doctoral fellow Takahiro Shintani that is featured on the cover of the Nov. 5 edition of Science magazine. Klionsky also recently edited the authoritative book on autophagy.

A cell undergoing autophagy assembles tiny capsules called vesicles that surround and chew up parts of the cellular machinery from within. Autophagic vesicles have been seen in cells undergoing programmed cell death, but the evidence is not clear yet whether they're trying to protect the cell from apoptosis, or hastening its demise.

"Autophagy is the only way to get rid of damaged parts of the cell without trashing the whole thing. So in a nerve cell, for example, you'd want autophagy
'"/>

Contact: Karl Leif Bates
batesk@umich.edu
734-647-1842
University of Michigan
4-Nov-2004


Page: 1 2 3

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Penn researchers discover how key protein stops inflammation
3. ASU researchers partner with UOP to make biofuel for military jets a reality
4. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
5. Penn researchers discover pathway that eliminates genetic defects in red blood cells
6. U-M researchers find family of on switches that cause prostate cancer
7. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
8. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
9. MGH researchers confirm that bone marrow restores fertility in female mice
10. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
11. U-M researchers identify gene involved in breast cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2018)... (PRWEB) , ... July 31, 2018 , ... GSL ... connect seamlessly with LabArchives , the leading cloud-based Electronic Lab Notebook (ELN) platform. ... LabArchives enables researchers to store all of their research data records in a secure, ...
(Date:7/30/2018)... Colo. (PRWEB) , ... July 30, 2018 , ... ... from preclinical trials on the beneficial impact of biofield energy healing treated Vitamin ... results show: ,     Over 260% increase in ALP, a ...
(Date:7/28/2018)... ... July 28, 2018 , ... Professor You-Lin Xu, ... (PolyU), has been honoured with the International Association for Wind Engineering (IAWE) Senior ... and bridge engineering in research, education, and application. Professor Xu is the first ...
Breaking Biology News(10 mins):
(Date:7/31/2018)... ... July 31, 2018 , ... ... that covers methods for extracting and using adipose tissue-derived stem cells to treat ... humans. While this patent covers Canada specifically, VetStem has been issued similar ...
(Date:7/31/2018)... ... 31, 2018 , ... Mahoney Environmental , a leading ... new website. The new website has been designed with improved functionality and navigation, ... Innovative to build a website created for the customer. The newly redesigned site ...
(Date:7/26/2018)... ... July 26, 2018 , ... Ariadne Afaganis, an ... biofield energy treated nutraceutical to improve anti-inflammatory and immune function responses. , Biomarkers ... the preclinical research, were significantly reduced. Results are as follows:, ...
(Date:7/25/2018)... ... July 25, 2018 , ... Dimitrius Anagnos, an ... to combat inflammation and autoimmune disorders. , The preclinical research assessed biomarkers ... data was reported:, Over 70% decrease in Interleukin ...
Breaking Biology Technology:
Cached News: