HOME >> BIOLOGY >> NEWS
U-M researchers identify gene involved in breast cancer

ANN ARBOR, Mich. Researchers at the University of Michigan Comprehensive Cancer Center have identified a gene linked to the development of an aggressive form of breast cancer.

The researchers found that the gene, FOXP3, suppresses tumor growth. FOXP3 is located on the X chromosome, which means a single mutation can effectively silence the gene. This is unusual, as only one other gene linked to cancer has been found on the X chromosome.

When one copy of the FOXP3 gene is silenced, the researchers found in studying mice, 90 percent of the mice spontaneously developed cancerous tumors. The researchers also looked at FOXP3 in human breast tissue cells, comparing cancerous and non-cancerous cells. FOXP3 was found to be either deleted or mutated in a substantial portion of the cancer sample: about 80 percent of the cancer tissues studied did not express the gene at all.

In addition, the researchers found FOXP3 to be a repressor of HER-2, a protein that typically marks a more aggressive form of breast cancer. The researchers believe FOXP3 suppresses the HER-2 gene. HER-2 can be activated by many different factors, but the researchers found that when FOXP3 is normal, it keeps HER-2 levels low; when FOXP3 is missing or mutated, HER-2 levels are likely to rise.

The researchers have shown that FOXP3 was reduced or missing in about 80 percent of the more than 600 cases of breast cancer tissue examined. At this point, the researchers do not know if FOXP3 can predict breast cancer risk, like the BRCA1 and BRCA2 genes, both of which are linked to a higher risk of breast cancer.

FOXP3 defects promote cancer development. We do not know whether this is a genetic defect that puts women at higher risk. For treatment, this gene could be quite important, but for diagnosis, its too early to tell, says study author Yang Liu, Ph.D., deNancrede Professor of Surgery at the U-M Medical School and co-director of the cancer immunology prog
'"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
26-Jul-2007


Page: 1 2

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Penn researchers discover how key protein stops inflammation
3. ASU researchers partner with UOP to make biofuel for military jets a reality
4. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
5. Penn researchers discover pathway that eliminates genetic defects in red blood cells
6. U-M researchers find family of on switches that cause prostate cancer
7. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
8. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
9. MGH researchers confirm that bone marrow restores fertility in female mice
10. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
11. Drug protects brain cells in Huntingtons disease model, researchers find

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/4/2019)... ... December 03, 2019 , ... ... technologies, development, and manufacturing solutions for drugs, biologics, gene therapies, and consumer ... Ethicann Pharmaceuticals Inc. (“Ethicann”), a Calgary-based pharmaceutical company using botanically sourced cannabinoid ...
(Date:11/27/2019)... (PRWEB) , ... November 25, 2019 , ... Though the ... for the more than 55 million travelers expected to hit the roads and the ... application worth it’s weight in truffle oil will offer a simple design, mouth-watering pictures ...
(Date:11/22/2019)... N.Y. (PRWEB) , ... November 21, 2019 , ... ... developed at Roswell Park Comprehensive Cancer Center have announced a major step forward ... Michael Ciesielski, PhD, have announced that the company, spun off from Roswell Park ...
Breaking Biology News(10 mins):
(Date:12/18/2019)... , ... December 17, 2019 , ... ... its 31st FDA clearance for reprocessing Electrophysiology (EP) devices since the company’s inception ... Stryker Sustainability Solutions and SterilMed (a Johnson & Johnson company) have received 2 ...
(Date:12/18/2019)... ... 2019 , ... Tune in to CNBC on Saturday, December 28th at 11:00aET ... for more information on this program. , With a look at Avatar Partners ... system to increase the efficiency, safety and effectiveness of equipment, systems, and processes for ...
(Date:12/6/2019)... ... December 06, 2019 , ... ... has received FDA 510(k) clearance for its latest CAPERE® Thrombectomy System for ... suggests the CAPERE® offers great benefits for first-in-line treatment for nonsurgical removal ...
(Date:12/4/2019)... ... December 03, 2019 , ... Absolute Antibody ... a partnership with the Recombinant Antibody Network (RAN), a consortium of three expert ... (UCSF) with a common goal to generate recombinant antibodies at a proteome-wide scale. ...
Breaking Biology Technology:
Cached News: