HOME >> BIOLOGY >> NEWS
U-M researchers identify gene involved in breast cancer

ANN ARBOR, Mich. Researchers at the University of Michigan Comprehensive Cancer Center have identified a gene linked to the development of an aggressive form of breast cancer.

The researchers found that the gene, FOXP3, suppresses tumor growth. FOXP3 is located on the X chromosome, which means a single mutation can effectively silence the gene. This is unusual, as only one other gene linked to cancer has been found on the X chromosome.

When one copy of the FOXP3 gene is silenced, the researchers found in studying mice, 90 percent of the mice spontaneously developed cancerous tumors. The researchers also looked at FOXP3 in human breast tissue cells, comparing cancerous and non-cancerous cells. FOXP3 was found to be either deleted or mutated in a substantial portion of the cancer sample: about 80 percent of the cancer tissues studied did not express the gene at all.

In addition, the researchers found FOXP3 to be a repressor of HER-2, a protein that typically marks a more aggressive form of breast cancer. The researchers believe FOXP3 suppresses the HER-2 gene. HER-2 can be activated by many different factors, but the researchers found that when FOXP3 is normal, it keeps HER-2 levels low; when FOXP3 is missing or mutated, HER-2 levels are likely to rise.

The researchers have shown that FOXP3 was reduced or missing in about 80 percent of the more than 600 cases of breast cancer tissue examined. At this point, the researchers do not know if FOXP3 can predict breast cancer risk, like the BRCA1 and BRCA2 genes, both of which are linked to a higher risk of breast cancer.

FOXP3 defects promote cancer development. We do not know whether this is a genetic defect that puts women at higher risk. For treatment, this gene could be quite important, but for diagnosis, its too early to tell, says study author Yang Liu, Ph.D., deNancrede Professor of Surgery at the U-M Medical School and co-director of the cancer immunology prog
'"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
26-Jul-2007


Page: 1 2

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Penn researchers discover how key protein stops inflammation
3. ASU researchers partner with UOP to make biofuel for military jets a reality
4. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
5. Penn researchers discover pathway that eliminates genetic defects in red blood cells
6. U-M researchers find family of on switches that cause prostate cancer
7. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
8. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
9. MGH researchers confirm that bone marrow restores fertility in female mice
10. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
11. Drug protects brain cells in Huntingtons disease model, researchers find

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/11/2018)... ... October 09, 2018 , ... ... identifies, counsels, and supports high-growth, high-impact life science and biotechnology companies, announced ... national nonprofit disease foundations to discuss their investment philosophies, explain their fund ...
(Date:10/11/2018)... ... , ... ODSC Europe 2018 - one of Open Data Science Conference ... from September 19-22. , As Europe’s largest applied data science conference, ODSC Europe ... days. Attendees were given key insights and hands-on training in deep learning, ...
(Date:10/5/2018)... ... October 05, 2018 , ... The Amino Acid Technologies ... 10% price increase across all markets in January 2019. , The global ... of protein — for the parenteral nutrition, biopharmaceutical, infant/medical food, supplement and nutrition ...
Breaking Biology News(10 mins):
(Date:10/3/2018)... ... October 03, 2018 , ... Milwaukee Area Technical College ... Wednesday, Oct. 17, from 3-7 p.m. in Room T129 in the T Building, 101 ... new CNC Swiss Lab. A ribbon cutting and formal program will be held at ...
(Date:9/29/2018)... (PRWEB) , ... September 29, 2018 , ... ... product enabling mid-level and early-stage companies to access the power of influence analytics ... our solutions available to a broader market that didn’t necessarily have access to ...
(Date:9/27/2018)... ... , ... Medable was named DPharm Idol at this year’s ... digitome, a digital representation of human health and disease, by removing the separation ... sources. Dr. Michelle Longmire, Co-Founder and CEO of Medable, explained that their approach ...
(Date:9/22/2018)... HAYWARD, Calif. and WESTMINSTER, Colo. (PRWEB) , ... ... ... Predicine and Flagship Biosciences are excited to announce a strategic venture. ... intelligence-enabled cTA® digital pathology platform provides complimentary and comprehensive biomarker profiling to ...
Breaking Biology Technology:
Cached News: