HOME >> BIOLOGY >> NEWS
U-M team identifies gene that regulates blood-forming fetal stem cells

ANN ARBOR, Mich. -- In the rancorous public debate over federal research funding, stem cells are generally assigned to one of two categories: embryonic or adult. But that's a false dichotomy and an oversimplification. A new University of Michigan study adds to mounting evidence that stem cells in the developing fetus are distinct from both embryonic and adult stem cells.

In the last several years, stem cell researchers have realized that fetal stem cells comprise a separate class. They recognized, for example, that fetal blood-forming stem cells in umbilical cord blood behave differently than adult blood-forming stem cells after transplantation into patients.

Now a U-M team led by Sean Morrison has identified the first known gene, Sox17, required for the maintenance of blood-forming stem cells in fetal mice, but not in adult mice. The discovery provides a critical insight into the mechanisms that distinguish fetal blood-forming stem cells from their adult counterparts.

The findings could also lead to a deeper understanding of diseases such as childhood leukemias, said Morrison, director of the U-M Center for Stem Cell Biology and a Howard Hughes Medical Institute investigator. Childhood leukemias are cancers that afflict blood-forming cells and hijack normal stem cell self-renewal mechanisms.

"One of the next questions in our cross hairs is whether Sox17 gets inappropriately activated in certain childhood leukemias---and that's an idea that nobody had in their mind before this work," Morrison said. "If it's true, it'll give us a new target for cancer."

The Sox17 results will be published online July 26 in the journal Cell. U-M's Injune Kim is lead author of the paper; Morrison and U-M's Thomas Saunders are co-authors.

"Identification of Sox17 could also facilitate efforts to form blood-forming stem cells from human embryonic stem cells, a goal that could enhance bone marrow transplantation," Kim said.'"/>

Contact: Jim Erickson
ericksn@umich.edu
734-647-1842
University of Michigan
26-Jul-2007


Page: 1 2

Related biology news :

1. New research identifies anti-viral protein that may predict who might be at risk to develop lupus
2. Study identifies new gene therapy tools for inherited blindness
3. Study identifies energy efficiency as reason for evolution of upright walking
4. Study identifies a common genetic risk factor for colorectal and prostate cancer
5. M. D. Anderson team identifies new oncogene for brain cancer
6. Weill Cornell team identifies potential new cancer drug target
7. Study identifies 5 genetic themes key to keeping stem cells in a primitive, flexible state
8. 454 sequencing identifies HIV drug resistance at early stage
9. Ultra deep sequencing identifies HIV drug resistance at early stage
10. Research team identifies new Alzheimers gene
11. A researcher identifies the parasites responsible for Chagas and Leishmaniasis epidemics

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... , ... June 04, 2019 , ... ... of orthopedic medical devices, today announced Q1-19 revenues of $31M, up 12% from ... with successful roll-out of strategic investments & operational excellence initiatives worldwide. , ...
(Date:6/4/2019)... ... ... Lajollacooks4u is delighted to announce it has been named as one of ... only to businesses that have achieved consistently outstanding traveler reviews on TripAdvisor, as well ... qualify for the Certificate of Excellence –- an award that only 10 percent of ...
(Date:5/31/2019)... , ... May 30, 2019 , ... ... testing company, and Mayo Clinic, have documented significant differences in the prevalence of ... and ethnic populations compared to non-Hispanic White women. Results will be presented at ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 30, 2019 , ... A study ... efficient delivery system for the sustained release of human placental stem cell (HPSC)-derived ... was able to deliver CM into the injured kidney, where it helped restore ...
(Date:5/15/2019)... ... 15, 2019 , ... Milton Hershey School® has named William Charles Ballough Harding ... biomedical industry, where he is changing lives by creating solutions to global healthcare challenges ... the vision of our founders – Milton and Catherine Hershey – who always hoped ...
(Date:5/14/2019)... LA JOLLA, Calif. (PRWEB) , ... May 14, 2019 , ... ... announces an office expansion, effectively doubling its space from 2,500 to 5,000 square feet. ... SneakPeek Early Gender DNA tests ,” says Gateway Genomics CEO, Chris Jacob. “The ...
(Date:5/4/2019)... Brazil (PRWEB) , ... May 03, 2019 , ... ... given by the President of the Dakila Pesquisas Association, the scientist and ufologist ... Councilmen 2019, in Brasília (DF). Urandir detailed the results of some research carried ...
Breaking Biology Technology:
Cached News: