Researchers at the University of Minnesota and the University of Illinois at Urbana-Champaign have developed a new therapeutic that neutralizes Toxic Shock Syndrome (TSS) more effectively than other treatments.
Toxic Shock Syndrome is a rare, life-threatening bacterial infection that can cause multi-organ failure and death. A major cause of the disease is a superantigen called staphylococcal enterotoxin B (SEB), which is produced by Staphylococcus aureus bacteria. SEB binds to T-lymphocytes in the body causing the release of cytokines, resulting in the dramatic blood pressure drop seen in TSS.
Currently, TSS can be treated with antibiotics to kill the bacteria and antibodies to neutralize SEB. But, as published in the May 21, 2007 issue of Nature Medicine, scientists have engineered a new high-affinity molecule known as V-beta which blocks SEB's ability to bind to T-cells. By targeting the early stages of disease onset, V-beta neutralizes SEB at a rate 2000 times more effective than typical antibody treatment.
"The development and efficacy of V-beta in animal models is a very significant advancement in infectious disease treatment," said Patrick Schlievert, Ph.D., co-author of the paper and professor of microbiology at the University of Minnesota Medical School. "It represents an easily produced, potential treatment for diseases caused by SEB and other superantigens associated with TSS."
Schlievert and colleague Marnie Peterson, Pharm.D., Ph.D., co-author and assistant professor at the University of Minnesota College of Pharmacy Department of Experimental and Clinical Pharmacology, studied the effects of V-beta on SEB in rabbit models. The treatment of rabbits with SEB was successful when given V-beta following onset of disease, after SEB had caused a high fever and symptoms of TSS, and after rabbits had been exposed to SEB on a continuous basis.