HOME >> BIOLOGY >> NEWS
U of M researchers show that increasing sugar processing in the liver can lower blood sugar

Researchers at the University of Minnesota have shown that increasing the concentration of a key regulator involved in glucose metabolism can improve the way the liver produces and disposes of the sugar glucose, the primary fuel of the body. Finding ways to increase that concentration could provide a treatment for diabetes and obesity. The research will be published in the Aug. 16 issue of Cell Metabolism.

The liver plays an important role in both type 1 and type 2 diabetes. In diabetic patients, the liver makes too much glucose, and muscles and fat are unable to take up or transport glucose so cells can use it.

"We thought if we could find a way to increase the amount of glucose the liver takes out of the blood, and decrease the amount produced by the liver, overall blood sugar levels would decrease," said Alex Lange, associate professor of biochemistry.

This process is dependant on a small regulator molecule, called fructose-2, 6-bisphosphate, that helps control glucose metabolism, or how the body uses and processes sugars.

Using a mouse model, biochemistry research assistant professor Chaodong Wu increased the concentration of the regulator molecule, and found that the mice's blood sugar went down. The mice were using more and producing less glucose.

Wu also noted other changes in the cell that have implications for obesity. When the concentration of the regulator was increased, there were changes in the food intake and overall metabolism. Just like in humans, when food intake is decreased and energy expenditure is increased, weight loss occurs.

Lange said if researchers could find a way to raise the level of this regulator in the liver of humans, for example, by preventing its breakdown, it could lead to a new treatment for diabetes, as well as obesity.


'"/>

Contact: Sara E. Buss
buss@umn.edu
612-624-2449
University of Minnesota
16-Aug-2005


Page: 1

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Penn researchers discover how key protein stops inflammation
3. ASU researchers partner with UOP to make biofuel for military jets a reality
4. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
5. Penn researchers discover pathway that eliminates genetic defects in red blood cells
6. U-M researchers find family of on switches that cause prostate cancer
7. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
8. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
9. MGH researchers confirm that bone marrow restores fertility in female mice
10. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
11. U-M researchers identify gene involved in breast cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... Janice Kephart , former 9/11 ... Partners, LLP (IdSP) , today issues the following ... March 6, 2017 Executive Order: Protecting the ... be instilled with greater confidence, enabling the reactivation ... applications are suspended by until at least July ...
(Date:4/13/2017)... , April 13, 2017 According to a new ... Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, ... IAM Market is expected to grow from USD 14.30 Billion in 2017 ... (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/6/2017)... Forecasts by Product Type (EAC), ... End-Use (Transportation & Logistics, Government & Public Sector, Utilities ... Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), ... you looking for a definitive report on the $27.9bn ... ...
Breaking Biology News(10 mins):
(Date:9/13/2017)... ... September 13, 2017 , ... ... sciences industry to improve patient outcomes and quality of life for more than ... been named a US expert to the International Standards Organization/Technical Committee 194: ...
(Date:9/12/2017)... ... September 12, 2017 , ... Avomeen.com, the analytical laboratory ... development companies will be exhibiting at the 16th annual Contract Pharma Conference to ... is an educational conference for pharma and bio-pharma professionals that has multiple ...
(Date:9/12/2017)... SALISBURY, MARYLAND (PRWEB) , ... September 12, 2017 ... ... Soybean Board for 2017-2018 are asked to submit a "pre-proposal” by October ... us the opportunity to greenlight projects that are aligned with our priorities, and ...
(Date:9/12/2017)... ... ... Facet Life Sciences, a leading provider of development solutions (software and services) ... joined the company’s Board of Directors. , Dr. Massa brings 38 years of ... he served as VP and Head of Global Regulatory Operations at Sanofi. During his ...
Breaking Biology Technology:
Cached News: