HOME >> BIOLOGY >> NEWS
U of M researchers show that increasing sugar processing in the liver can lower blood sugar

Researchers at the University of Minnesota have shown that increasing the concentration of a key regulator involved in glucose metabolism can improve the way the liver produces and disposes of the sugar glucose, the primary fuel of the body. Finding ways to increase that concentration could provide a treatment for diabetes and obesity. The research will be published in the Aug. 16 issue of Cell Metabolism.

The liver plays an important role in both type 1 and type 2 diabetes. In diabetic patients, the liver makes too much glucose, and muscles and fat are unable to take up or transport glucose so cells can use it.

"We thought if we could find a way to increase the amount of glucose the liver takes out of the blood, and decrease the amount produced by the liver, overall blood sugar levels would decrease," said Alex Lange, associate professor of biochemistry.

This process is dependant on a small regulator molecule, called fructose-2, 6-bisphosphate, that helps control glucose metabolism, or how the body uses and processes sugars.

Using a mouse model, biochemistry research assistant professor Chaodong Wu increased the concentration of the regulator molecule, and found that the mice's blood sugar went down. The mice were using more and producing less glucose.

Wu also noted other changes in the cell that have implications for obesity. When the concentration of the regulator was increased, there were changes in the food intake and overall metabolism. Just like in humans, when food intake is decreased and energy expenditure is increased, weight loss occurs.

Lange said if researchers could find a way to raise the level of this regulator in the liver of humans, for example, by preventing its breakdown, it could lead to a new treatment for diabetes, as well as obesity.


'"/>

Contact: Sara E. Buss
buss@umn.edu
612-624-2449
University of Minnesota
16-Aug-2005


Page: 1

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Penn researchers discover how key protein stops inflammation
3. ASU researchers partner with UOP to make biofuel for military jets a reality
4. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
5. Penn researchers discover pathway that eliminates genetic defects in red blood cells
6. U-M researchers find family of on switches that cause prostate cancer
7. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
8. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
9. MGH researchers confirm that bone marrow restores fertility in female mice
10. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
11. U-M researchers identify gene involved in breast cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2017)... Inc., a global expert in SoC-based imaging and computing solutions, has ... features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® ... be showcased during the upcoming Medtec Japan at Tokyo Big Sight ... Las Vegas Convention Center April 24-27. ... Click here for an image of the ...
(Date:4/13/2017)... Calif. , April 13, 2017 UBM,s ... York will feature emerging and evolving technology ... Both Innovation Summits will run alongside the expo portion ... speaker sessions, panels and demonstrations focused on trending topics ... largest advanced design and manufacturing event will take place ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, ... secure authentication solutions, today announced that it has ... Advanced Research Projects Activity (IARPA) to develop next-generation ... program. "Innovation has been a driving ... Thor program will allow us to innovate and ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... ... July 20, 2017 , ... VIC Technology Venture Development™ (VIC™), ... of directors. This addition continues to strengthen and diversify VIC’s board. , "We ... Chairman. “He is a highly accomplished business executive with a broad range of experience ...
(Date:7/18/2017)... ... July 18, 2017 , ... Nanomedical Diagnostics, a cutting-edge life ... launch of a new NTA biosensor chip for use with its label-free Agile ... of polyhistidine-tagged (His-tagged) molecules quickly and reliably. , “Recombinant proteins are an ...
(Date:7/18/2017)... Washington, DC (PRWEB) , ... July 18, 2017 ... ... for the Allotrope Framework, and has released the first phase of the Allotrope ... Bio-IT World’s Best Practices Awards were created to “not only elevate the critical ...
(Date:7/17/2017)... , ... July 17, 2017 , ... ... and analytical instruments announced the launch of its new line of Heavy-Duty Orbital ... shaker models (both analog and digital) for laboratory applications. These shakers are ...
Breaking Biology Technology:
Cached News: