HOME >> BIOLOGY >> NEWS
U of M researchers show that increasing sugar processing in the liver can lower blood sugar

Researchers at the University of Minnesota have shown that increasing the concentration of a key regulator involved in glucose metabolism can improve the way the liver produces and disposes of the sugar glucose, the primary fuel of the body. Finding ways to increase that concentration could provide a treatment for diabetes and obesity. The research will be published in the Aug. 16 issue of Cell Metabolism.

The liver plays an important role in both type 1 and type 2 diabetes. In diabetic patients, the liver makes too much glucose, and muscles and fat are unable to take up or transport glucose so cells can use it.

"We thought if we could find a way to increase the amount of glucose the liver takes out of the blood, and decrease the amount produced by the liver, overall blood sugar levels would decrease," said Alex Lange, associate professor of biochemistry.

This process is dependant on a small regulator molecule, called fructose-2, 6-bisphosphate, that helps control glucose metabolism, or how the body uses and processes sugars.

Using a mouse model, biochemistry research assistant professor Chaodong Wu increased the concentration of the regulator molecule, and found that the mice's blood sugar went down. The mice were using more and producing less glucose.

Wu also noted other changes in the cell that have implications for obesity. When the concentration of the regulator was increased, there were changes in the food intake and overall metabolism. Just like in humans, when food intake is decreased and energy expenditure is increased, weight loss occurs.

Lange said if researchers could find a way to raise the level of this regulator in the liver of humans, for example, by preventing its breakdown, it could lead to a new treatment for diabetes, as well as obesity.


'"/>

Contact: Sara E. Buss
buss@umn.edu
612-624-2449
University of Minnesota
16-Aug-2005


Page: 1

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Penn researchers discover how key protein stops inflammation
3. ASU researchers partner with UOP to make biofuel for military jets a reality
4. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
5. Penn researchers discover pathway that eliminates genetic defects in red blood cells
6. U-M researchers find family of on switches that cause prostate cancer
7. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
8. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
9. MGH researchers confirm that bone marrow restores fertility in female mice
10. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
11. U-M researchers identify gene involved in breast cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/18/2016)... March 18, 2016 --> ... Biometrics, ICT, Manned & Unmanned Vehicles, Physical infrastructure and Perimeter ... companies in the border security market and the continuing migration ... Europe has led visiongain to publish ... success. --> defence & security companies in ...
(Date:3/15/2016)... -- Yissum Research Development Company of the Hebrew ... Hebrew University, announced today the formation of Neteera ... human biological indicators. Neteera Technologies has completed its first ... ... emissions from sweat ducts, enables reliable and speedy biometric ...
(Date:3/11/2016)... 11, 2016 http://www.apimages.com ) - --> ... is available at AP Images ( http://www.apimages.com ) - ... used to produce the new refugee identity cards. DERMALOG will be ... CeBIT in Hanover next week.   --> ... be used to produce the new refugee identity cards. DERMALOG will ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... , ... April 29, 2016 , ... ... devices used in spinal surgical procedures, today announced the completion of a significant ... proposition for current and future customers and partners. Kohlberg & Company, L.L.C. ...
(Date:4/29/2016)... Louisville, KY and San Diego, CA (PRWEB) , ... April 29, ... ... the National Stem Cell Foundation (NSCF) to support the development of a patient-specific stem ... by Dr. Andrés Bratt-Leal in the lab of Dr. Jeanne Loring at The Scripps ...
(Date:4/28/2016)... , April 28, 2016 The ... and Brayton Cryocoolers), Service (Technical Support, Product Repairs & ... - Global Forecast to 2022", published by MarketsandMarkets, the ... Billion by 2022, at a CAGR of 7.29% between ... data Tables and 94 Figures spread through 159 Pages ...
(Date:4/28/2016)... (PRWEB) , ... April 28, 2016 , ... ... Asymmetrex will deliver a talk on its first-in-class technologies for tissue stem ... 2016 Meeting on RNAiMicroRNA Biology to Reprogramming & CRISPR-based Genome Engineering in ...
Breaking Biology Technology:
Cached News: