HOME >> BIOLOGY >> NEWS
U of S researchers develop new vaccine candidate against hepatitis C

Researchers at the University of Saskatchewan's Vaccine and Infectious Disease Organization (VIDO) have developed a vaccine candidate for hepatitis C, leading to hope in the fight against a disease for which no vaccines are yet available.

VIDO is the first in Canada to show that this vaccination technique may be effective against HCV. The study was published in this month's Journal of General Virology.

The team, funded by the Canadian Institutes of Health Research (CIHR) and the Canadian Network for Vaccines and Immunotherapeutics (CANVAC), produced a vaccine candidate that decreased the amount of a carrier virus expressing hepatitis C virus (HCV) protein in mice by 100,000 times compared to the control.

"This technique uses the body's own cells, called dendritic cells, to vaccinate against hepatitis C," said Dr. Bhagirath Singh, Scientific Director of the CIHR Institute of Infection and Immunity.

Dendritic cells are key components of the immune system, activating and shaping the immune response. "The vaccine reduced the amount of hepatitis C protein in a highly significant manner," he said. "This offers a very promising approach to prevent liver disease caused by the virus and to ultimately eliminate it from the body."

About 20 per cent of people who contract HCV overcome the virus on their own. For those who develop chronic hepatitis, the immune system cannot clear the infection.

"In patients with chronic hepatitis C, there is evidence that the function of their dendritic cells is altered," said Sylvia van den Hurk, senior VIDO scientist and member of the research team that developed the vaccine candidate.

"We thought that if we could 'teach' the dendritic cells how to properly activate the immune response and deliver them back to the patient as a vaccine, the patients would clear or at least control the infection."

HCV is the leading cause for liver transplants in the wester
'"/>

Contact: University of Saskatchewan Communications
communications@usask.ca
Canadian Institutes of Health Research
10-Jan-2006


Page: 1 2

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Penn researchers discover how key protein stops inflammation
3. ASU researchers partner with UOP to make biofuel for military jets a reality
4. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
5. Penn researchers discover pathway that eliminates genetic defects in red blood cells
6. U-M researchers find family of on switches that cause prostate cancer
7. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
8. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
9. MGH researchers confirm that bone marrow restores fertility in female mice
10. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
11. U-M researchers identify gene involved in breast cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2020)... ... July 30, 2020 , ... BioFactura, Inc. today ... by the Joint Science & Technology Office—Chemical and Biological Defense (JSTO-CBD) of the ... and scale-up a highly efficient mammalian cell culture-based bioprocess suitable to meet surge ...
(Date:7/18/2020)... ... ... Commercial launch readiness is a critical stage in a product life cycle. While ... global economic downturn will only increase price pressures overall for the industry. The era ... from every product launch is critical. However, history shows that only a third of ...
(Date:7/2/2020)... REDWOOD CITY, Calif. (PRWEB) , ... July 01, ... ... stage biotech company, presented its phase 1a findings of Neihulizumab, a biologic for ... annual conference in June 2020. Led by hemato-oncologist Dr. Paul J Martin of ...
Breaking Biology News(10 mins):
(Date:7/7/2020)... DIEGO (PRWEB) , ... July 06, 2020 , ... R3 ... new program featuring up to 200 million stem cells. Depending on the patient's condition, ... seniors in the US will die having some form of Alzheimers dementia, and the ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... launch of a new clinical diagnostics immuno-oncology service, TissueInsight . TissueInsight ... , “Flagship’s TissueInsight is a service that aids pathologists, oncologists, and immunologists ...
(Date:6/28/2020)... ... June 26, 2020 , ... The Security Industry Association ... strong opposition to the recently introduced bicameral Facial Recognition and Biometric Technology ... federal use of nearly all biometric and related image analytics technologies, incorrectly labeling ...
(Date:6/23/2020)... ... June 22, 2020 , ... Dracen Pharmaceuticals Inc., ... presented June 22-24 during the American Association for Cancer Research Virtual meeting. One ... the potent, consistent single agent activity in KEAP1 mutant tumor models of NSCLC. ...
Breaking Biology Technology:
Cached News: