HOME >> BIOLOGY >> NEWS
U of T researcher links schizophrenia, gene mutations

The supersensitivity to dopamine that is characteristic of schizophrenia can be caused by mutations to a wide variety of genes, rather than alterations to just two or three specific genes, says a University of Toronto researcher.

In research published in the Feb. 15 edition of the Proceedings of the National Academy of Sciences, University of Toronto pharmacology professor Philip Seeman and his 16 colleagues in eight universities show that mutations to genes that have no relation to the brain's dopamine receptors can still cause those receptors to become highly sensitive to their own dopamine, a condition that leads to psychosis.

By examining brain tissue from mice with various gene mutations, the researchers determined that the brain appears to compensate for the altered gene by becoming supersensitive to dopamine. Dopamine is a neurotransmitter that allows people to move, think and feel.

"The altered genes may provoke the brain to respond and compensate, and compensation often involves the dopamine system going into high gear," says Seeman. "The brain knows about mistakes, and to protect itself, it makes sense for the compensation to re-adjust the dopamine system to preserve the functions such as movement and thought that the body and brain needs."

An excessively active dopamine system can trigger the hallucinations and delusions experienced in schizophrenia, amphetamine drug abuse or Alzheimer's disease. In drug abuse, the reaction is temporary; in schizophrenia, it recurs.

"This research brings together two worlds: the psychosis of drug abuse and schizophrenia," says Seeman. "There's a common denominator based on the dopamine receptor."

It also offers a new direction for research into schizophrenia.

"Vast amounts of money are being spent to look for the magical two or three genes that cause psychosis but it could be many genes and that includes genes that have nothing to do with dopamine," said S
'"/>

Contact: Philip Seeman
philip.seeman@utoronto.ca
416-978-4891
University of Toronto
14-Feb-2005


Page: 1 2

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Penn researchers discover how key protein stops inflammation
3. ASU researchers partner with UOP to make biofuel for military jets a reality
4. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
5. Penn researchers discover pathway that eliminates genetic defects in red blood cells
6. U-M researchers find family of on switches that cause prostate cancer
7. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
8. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
9. MGH researchers confirm that bone marrow restores fertility in female mice
10. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
11. U-M researchers identify gene involved in breast cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/18/2018)... ... October 18, 2018 , ... On June 11 of this year, ... of gene-editing therapeutics to hold its collective breath. Two different research teams independently ... of p53 gene mutation. Mutations in the p53 gene have the distinction of ...
(Date:10/17/2018)... ... October 17, 2018 , ... Maintenance of Certification (MOC) ... 65 percent of physicians surveyed by MDLinx, a medical news, information, and education ... specialties revealed that many physicians are frustrated with the mandated MOC requirements that ...
(Date:10/16/2018)... POWAY, Calif. (PRWEB) , ... October 16, 2018 , ... ... taken to look for a possible tumor and instead, Sam’s veterinarian found that he ... not experiencing any obvious discomfort, so his owner placed him on supplements for the ...
Breaking Biology News(10 mins):
(Date:10/13/2018)... , ... October 12, 2018 , ... ... society for laser education, innovation and commercialization, celebrates its 50th birthday in New ... Applications of Lasers and Electro-Optics (ICALEO) conference. , In celebration of its ...
(Date:10/5/2018)... ... October 04, 2018 , ... Karius , ... University, announced today at IDWeek™ 2018 the positive results of a study demonstrating ... plasma, accurately identified causative pathogens in patients with infective endocarditis even when blood ...
(Date:10/2/2018)... ... October 02, 2018 , ... Finalists ... LLC’s (Locus Bio-Energy) AssurEOR product line was chosen for its advancements in the ... Information, honor leading innovations in upstream oil applications that are positively impacting the ...
(Date:9/28/2018)... Calif. (PRWEB) , ... September 28, 2018 , ... ... interactive virtual events for tech innovators, engineers, and scientists from around the world, ... at the National University of San Marcos, as the winner of the LabRoots ...
Breaking Biology Technology:
Cached News: