HOME >> BIOLOGY >> NEWS
UC Davis researchers use heated nanoprobes to destroy breast cancer cells in mice

(SACRAMENTO, Calif.) -- In experiments with laboratory mice that bear aggressive human breast cancers, UC Davis researchers have used hot nanoprobes to slow the growth of tumors -- without damage to surrounding healthy tissue. The researchers describe their work in the March issue of the Journal of Nuclear Medicine.

"We have demonstrated that the system is feasible in laboratory mice. The next step will be clinical testing in patients," said Sally DeNardo, a professor of internal medicine and radiology at UC Davis and lead author of the study.

Many researchers have studied heat as a potential treatment for cancer, but the difficulty of confining heat within the tumor and predicting an effective heat dose has limited its use. The UC Davis research, carried out in collaboration with scientists from Triton BioSystems in Boston, seeks to solve this problem.

The experimental system uses bioprobes created by wedding magnetized iron-oxide nanospheres to radiolabeled monoclonal antibodies. The bioprobes are cloaked in polymers and sugars that render them nearly invisible to the body's immune system.

DeNardo and her colleagues infused trillions of the probes -- more than 10,000 can fit on the end of a straight pin -- into the bloodstreams of laboratory mice bearing human breast tumors. Once in the bloodstream, the probes began to seek out and latch onto receptors on the surface of malignant cells.

Three days later, the team applied an alternating magnetic field to the tumor region, causing the magnetic nanospheres latched onto the tumor cells to change polarity thousands of times per second, instantaneously generating heat. As soon as the AMF stopped, the bioprobes cooled down.

Mice in the study received a series of AMF bursts in a single 20-minute treatment. Dosing was calculated using an equation that included tumor concentration of bioprobes, heating rate of partic
'"/>

Contact: Claudia Morain
claudia.morain@ucdmc.ucdavis.edu
916-734-9023
University of California, Davis - Health System
6-Mar-2007


Page: 1 2

Related biology news :

1. UC Davis is partner in new $125 million federal bioenergy research center
2. UC Davis study finds high arsenic levels in herbal kelp supplements
3. UC Davis wins new national center for avian flu research
4. UC Davis researchers discover key to bodys ability to detect subtle temperature changes
5. APS names UC Davis professor Bodil Schmidt-Nielsen Distinguished Mentor and Scientist
6. UC Davis scientists groundbreaking research: Mate-attracting chemicals
7. UC Davis breast cancer researchers report new insights into ductal carcinoma in situ
8. British cattle give TB to badgers, finds UC Davis expert
9. UC Davis study finds distinct genetic profiles
10. UC Davis researchers move biotechnology closer to replacing electronic pacemakers
11. UC Davis study finds brain cell regulator is volume control, not on/off switch

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/12/2019)... (PRWEB) , ... February 12, 2019 , ... Ava, a ... old, she partially tore one of her cruciate ligaments. Just one year later, ... by nature, was able to recover without surgical intervention and resumed her normal activities ...
(Date:2/11/2019)... ... February 11, 2019 , ... Bode Technology (Bode), ... forensic genealogy service offering to law enforcement investigators and crime laboratories. ... develop ancestral relationships between samples and deliver leads to our clients. , For ...
(Date:2/6/2019)... ... February 04, 2019 , ... ... Explorerâ„¢ story which provides insights to help individuals understand how the gut microbes ... wellness. , After individuals eat foods that contain choline and L-carnitine, such ...
Breaking Biology News(10 mins):
(Date:1/24/2019)... ... January 23, 2019 , ... Through its ... research support in study design, planning, sample collection, and analysis to researchers at ... Campus in Trinidad led by Dr. Elaine Monica Davis, MBBS, MPhil, Lecturer of ...
(Date:1/20/2019)... Milwaukee (PRWEB) , ... January 17, 2019 , ... The ... release of its Patient Education program , a new initiative for 2019. Designed ... is designed to educate and inform patients, families, and the public on the status ...
(Date:1/15/2019)... (PRWEB) , ... January 15, 2019 , ... With the U.S. Congress designating January as ... transmitted disease (STD) testing service, today announces tips to help reduce the risk of Cervical ... Human Papillomavirus (HPV). Genital HPV is the #1 most common STD and an ...
(Date:1/10/2019)... ... January 08, 2019 , ... ... innovative spinal implant company, announced today that SAGICO will be represented at ... The annual J.P. Morgan Healthcare Conference is the largest and most informative ...
Breaking Biology Technology:
Cached News: