HOME >> BIOLOGY >> NEWS
UCF professor finds bacterial pathogen may be key to understanding cancer development

ORLANDO A research team including University of Central Florida Microbiology Professor Keith Ireton is using the bacterial pathogen Listeria Monocytogenes to understand the mechanisms of cell growth and cancer development.

In research published this month in the Journal of Biological Chemistry, the team found that a Listeria protein called InlB induces internalization and degradation of a human receptor known as Met. Met has been implicated in the development of some cancers.

Lisa A. Elferink at the University of Texas Medical Branch led the team. She and Ireton found that the ability of InlB to induce Met internalization and degradation requires a human protein called Cbl. If scientists could figure out how to control Cbl, such knowledge might lead to the development of drugs that induce the destruction of Met and are useful in treating Met-related cancers.

Ireton is an expert on Listeria monocytogenes, a cause of food poisoning. He has long studied how it enters into cells of the human body, and explains the mechanism in this months issue of the journal Cellular Microbiology.

We found that Listeria actually provokes human epithelial cells (cells lining the small intestine) into ingesting bacteria, Ireton said. When Listeria contacts an epithelial cell, the bacterium causes changes in the cells cytoskeleton that allow the cell to swallow up the bacterium. We discovered that a human protein called CrkII plays a critical role in stimulating internalization of Listeria by somehow controlling the cytoskeleton.

Listeria is a potentially deadly pathogen, causing abortions in pregnant women and meningitis in those with compromised immune systems, resulting in about a 25 percent mortality rate.

The findings are important in helping to understand and control the spread of bacteria that are a cause of potentially fatal food poisoning. Ireton said the bacteria can live outside animal hosts. Sources include d
'"/>

Contact: Chad Binette
cbinette@mail.ucf.edu
407-823-6312
University of Central Florida
28-Jun-2007


Page: 1 2

Related biology news :

1. Decorated UH professor to help choose nations top scientists
2. Cancer research specialist and HSPH professor awarded Medal of Honor from WHO cancer agency
3. 2 MSU professors spearhead international water project
4. WPI professor to represent American Mathematical Society at exhibition on science funding
5. NJIT professor says certain home shapes and roofs hold up best in hurricane
6. Dartmouth professor makes case for ethically universal stem cell lines
7. Computer science professor awarded $400,000 from National Science Foundation
8. FSU engineering professor growing bone in a lab
9. LSU professor involved in genome sequencing of the first marsupial
10. 5 Stanford professors elected to National Academy of Sciences
11. National Academy of Sciences elects 2 Rutgers professors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2019)... Va. (PRWEB) , ... June 14, 2019 , ... Molecular ... is estimated to be $8,760 million in 2019. Major segments that are expected ... These are all broken out and forecasted as segments in Kalorama’s The World ...
(Date:6/6/2019)... ... June 05, 2019 , ... MedTech Breakthrough , an ... and medical technology market, announced that it has selected Medacta International’s MySpine® MC ... in the 2019 MedTech Breakthrough Awards program. , Medacta® is ...
(Date:6/4/2019)... ... June 04, 2019 , ... Harper was three years old when her ... elbow dysplasia, which caused painful osteoarthritis in the joints. She was referred to ... heartbroken. , The surgical specialist, Dr. Christopher Eich of Southern California Veterinary Specialty ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... 2019 , ... World Compliance Seminars today announced a live ... Boston, MA. This peer recommended interactive workshop is always selected by professionals at ... off with a compendial treatment of Data Integrity fundamentals. After laying the groundwork, ...
(Date:5/15/2019)... ... May 15, 2019 , ... Milton Hershey School® has named William ... work within the biomedical industry, where he is changing lives by creating solutions to ... “William Harding epitomizes the vision of our founders – Milton and Catherine Hershey – ...
(Date:5/7/2019)... , ... May 06, 2019 , ... ... resource for the growing number of repositories being asked to store cellular products ... to the team of contributors who are world leaders, who have shared their ...
(Date:5/2/2019)... ... 2019 , ... Stay on top of current hot topics through free webinars ... all webinars is free, so be sure to register today to save your place! ... to see our upcoming webinars: , CLINICAL TRIALS , May 7 – Oncology ...
Breaking Biology Technology:
Cached News: