UCI researchers define estrogen's role in limiting heart disease in women

Irvine, Calif., July 19, 2005 -- UC Irvine School of Medicine researchers have identified how estrogen helps prevents a cardiac ailment often seen in women who have heart attacks. This research provides further evidence that hormone replacement therapy after menopause can help prevent certain forms of cardiovascular disease in women.

In tests done on female mice and mice heart cells, Dr. Ellis R. Levin and his UCI colleagues found that estrogen triggers molecular activity that blocks cardiac hypertrophy, or heart enlargement. This thickening of tissue in the heart ventricles is seen in almost 80 percent of people following heart attacks. Cardiac hypertrophy also commonly results from long-standing hypertension and leads to a poorly functioning heart and heart failure in many instances. Previous studies have indicated that premenopausal women have lower rates of heart disease than men, a rate that significantly rises in women after menopause.

Study results appear in the July 15 issue of the Journal of Biological Chemistry.

The results will continue a debate raised by the Women's Health Initiative over whether estrogen plays any beneficial role with cardiac disease in women. The initiative is a recently completed 15-year research program funded by the National Institutes of Health to address the most common causes of death, disability and poor quality of life in postmenopausal women, and some of its study data indicated that estrogen offered no protection against the development of arteriosclerotic heart disease. A recent article published in Science by Drs. Michael Mendelsohn and Richard Karas of Tufts University School of Medicine, however, addressed concerns of drawing conclusions based on the Women's Health Initiative data.

"There has been intense reaction to the Women's Health Initiative report indicating that estrogen is not beneficial in preventing coronary heart disease," said Levin, a professor of medicine, biochemistry

Contact: Tom Vasich
University of California - Irvine

Page: 1 2

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Penn researchers discover how key protein stops inflammation
3. ASU researchers partner with UOP to make biofuel for military jets a reality
4. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
5. Penn researchers discover pathway that eliminates genetic defects in red blood cells
6. U-M researchers find family of on switches that cause prostate cancer
7. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
8. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
9. MGH researchers confirm that bone marrow restores fertility in female mice
10. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
11. U-M researchers identify gene involved in breast cancer

Post Your Comments:

(Date:7/31/2020)... ... July 30, 2020 , ... BioFactura, Inc. ... awarded by the Joint Science & Technology Office—Chemical and Biological Defense (JSTO-CBD) of ... optimize, and scale-up a highly efficient mammalian cell culture-based bioprocess suitable to meet ...
(Date:7/18/2020)... ... July 17, 2020 , ... Commercial launch readiness is a critical stage in ... COVID cure or vaccine, the global economic downturn will only increase price pressures overall ... away and capturing full value from every product launch is critical. However, history shows ...
(Date:7/2/2020)... ... 01, 2020 , ... AltruBio Inc. http://www.altrubio.com , a ... for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European Hematology Association ... of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase 1 single ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 30, 2020 , ... ... industry, today announced the release of its signature product called Beacon - ... (MSLs) and other field medical professionals. , Beacon helps MSLs streamline ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra , ... sciences and food industries, is pleased to announce that Charles Galea has joined ... Development. , Charles is an accomplished and results-driven sales executive with over 10 ...
(Date:7/7/2020)... ... July 06, 2020 , ... R3 International is now offering ... to 200 million stem cells. Depending on the patient's condition, treatment may be offered ... will die having some form of Alzheimers dementia, and the incidence continues to increase ...
(Date:6/28/2020)... ... June 25, 2020 , ... The Indoor Lab, a leading provider of sensor ... of all types to ensure cleanliness, distancing and occupancy with its patent pending WipeAway™ ... enabled business will provide a health performance index system that scores all aspects of ...
Breaking Biology Technology:
Cached News: