UCI scientists discover a new healthy ro...( roplets dropped as the embryo moved fro...)

UCI scientists discover a new healthy role for fat

roplets dropped as the embryo moved from early development to later stages, indicating that the histones moved from the droplets to the nucleus as they were needed. In essence, the fat droplets acted as a warehouse where the proteins could be stored until needed by the nucleus of the cell.

Gross and his colleagues believe the droplets serve this purpose not just for histones, but for other excess proteins, as well. This has implications for how fat may be helping fight certain diseases when too much of certain proteins are produced.

"In prion diseases, such as Mad Cow Disease, for example, proteins in the brain are misshapen," Gross said. "They become abnormal, clump together and accumulate on brain tissue. Although we have no evidence yet that fat droplets could help with this, prion diseases are one area in which we can explore further to see if these droplets are helping keep excess bothersome proteins out of the way."

Gross emphasized that clinical trials would be needed to evaluate whether storage of proteins on fat droplets is important for human health.

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Contact: Farnaz Khadem
fkhadem@uci.edu
949-824-5484
University of California - Irvine
19-Sep-2006

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