HOME >> BIOLOGY >> NEWS
UCLA researchers reprogram normal tissue cells into embryonic stem cells

Researchers at the Institute for Stem Cell Biology and Medicine at UCLA were able to take normal tissue cells and reprogram them into cells with the same unlimited properties as embryonic stem cells, the cells that are able to give rise to every cell type found in the body.

The work, done in mouse models, appears in the inaugural June 7, 2007 issue of Cell Stem Cell, published by Cell Press. UCLA researchers, working closely with stem cell scientists at Harvard, took mouse fibroblasts, cells that develop into connective tissue, and added four transcription factors that bind to special sites on the DNA. Using this process, they were able to turn the fibroblasts into pluripotent cells that, in every aspect tested, were identical to embryonic stem cells.

The implications for disease treatment could be staggering. Reprogramming adult stem cells into embryonic stem cells could generate a potentially limitless source of immune-compatible cells for tissue engineering and transplantation medicine. If the work can be replicated in human cells, it may mean that a patients skin cells, for example, could be reprogrammed to become embryonic stem cells. Those embryonic stem cells could then be prodded into becoming various cells types beta islet cells to treat diabetes, hematopoetic cells to create a new blood supply for a leukemia patient, motor neuron cells to treat Parkinsons disease.

If we can recreate this in human cells, it has significant implications for regenerative therapies, said Kathrin Plath, an assistant professor of biological chemistry, a researcher with the Institute for Stem Cell Biology and Medicine at UCLA (ISCBM) and co-lead author of the study. Our reprogrammed cells were virtually indistinguishable from embryonic stem cells. We could find no evidence that they were different in any way. We were rather surprised at how well this reprogramming worked.

The finding also is significant in that this new technique co
'"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-435-9457
University of California - Los Angeles
6-Jun-2007


Page: 1 2 3

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Penn researchers discover how key protein stops inflammation
3. ASU researchers partner with UOP to make biofuel for military jets a reality
4. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
5. Penn researchers discover pathway that eliminates genetic defects in red blood cells
6. U-M researchers find family of on switches that cause prostate cancer
7. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
8. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
9. MGH researchers confirm that bone marrow restores fertility in female mice
10. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
11. U-M researchers identify gene involved in breast cancer

Post Your Comments:
(Date:4/23/2014)... a newly coined term for novels and films which focus ... of Copenhagen shows how these fictions serve as a mental ... climate change and imagine other living conditions. , "Global ... the atmosphere; it is also a cultural phenomenon in which ... the films we see. And there are so many of ...
(Date:4/23/2014)... at the University of Houston (UH) is working to ... His work is supported by a $1.8 million grant ... Blood transfusions save millions of lives every year. They ... for instance, routine surgeries would become life threatening. This ... that transfusions of red blood cells stored in a ...
(Date:4/22/2014)... There,s a new secret to get your child to behave ... , A new Cornell study published in Eating Behaviors ... they had to bite with their front teeth such as ... rowdier than when these foods had been cut. ... as aggressive toward other kids," said Brian Wansink, Professor and ...
Breaking Biology News(10 mins):Fiction prepares us for a world changed by global warming 2Fiction prepares us for a world changed by global warming 3UH biomedical engineer works to make blood transfusions safer 2UH biomedical engineer works to make blood transfusions safer 3Biting vs. chewing 2
(Date:1/15/2014)... January 15, 2014 More than 5 ... about 1 in 3 seniors will die with Alzheimer’s ... These jaw-dropping figures have shocked many Americans into looking ... help prevent these tragic age-related cognitive disorders. Jonathan Weisman, ...
(Date:1/15/2014)... 2014 DTS Language Services, Inc . ... Portal for Life Science organizations who need document translations. ... matter of their documents in advance with a selection of ... of translations, often a critical factor in clinical and scientific ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of Notched Sound ... Patients listen to sound therapy that is tailor-made for ... to months, their tinnitus volume decreases. , AudioNotch has previously ... Notched White Noise. Now, AudioNotch is pleased to announce to ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Carahsoft and ... Thursday, January 23, 2014 at 2pm EST (11am PST), ... The topic focuses on how technology can turn raw, ... decisions for government agencies. The online webinar will last ...
Breaking Biology Technology:Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2DTS Improves Efficiency for Life Science Document Translations 2Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
Cached News: