HOME >> BIOLOGY >> NEWS
UCLA study uncovers new risk factor for schizophrenia

UCLA scientists have discovered that infants who possess a specific immune gene that too closely resembles their mothers' are more likely to develop schizophrenia later in life. Reported in the October issue of the American Journal of Human Genetics, the study suggests that the genetic match may increase fetal susceptibility to schizophrenia, particularly in females.

HLA-B is one of a family of genes called the human leukocyte antigen (HLA) complex, which helps the immune system distinguish the body's own proteins from those made by foreign invaders, such as viruses and bacteria. The developing fetus inherits one copy of the HLA-B gene from each parent.

"Our findings clearly suggest that schizophrenia risk rises, especially in daughters, when the child's HLA-B gene too closely matches its mother's," explained Christina Palmer, Ph.D, UCLA associate professor of psychiatry and human genetics and a researcher at the Semel Institute for Neuroscience and Human Behavior. "We don't know whether sons who match are not affected -- or are more affected and less likely to come to term."

In 2002, Palmer and her colleagues discovered that infants are twice as likely to develop schizophrenia later in life when they possess a cell protein called Rhesus (Rh) factor that their mothers lack. Later studies found that male babies were more vulnerable to the consequences of Rh incompatibility than female infants.

The UCLA team hypothesized that females must possess a different fetal risk factor that predisposes them to schizophrenia. They decided to focus on HLA-B, which previous studies had linked to prenatal complications, like preeclampsia and low birth weight, that in turn have been associated with schizophrenia.

The researchers studied a group of 274 Finnish families in which at least one child had been diagnosed with schizophrenia or a related psychosis. In this group, 484 offspring had been diagnosed with the disease.'"/>

Contact: Elaine Schmidt
eschmidt@mednet.ucla.edu
310-794-2272
University of California - Los Angeles
5-Sep-2006


Page: 1 2

Related biology news :

1. New study warns limited carbon market puts 20 percent of tropical forest at risk
2. Clones on task serve greater good, evolutionary study shows
3. Pollution causes 40 percent of deaths worldwide, study finds
4. A study by the MUHC and McGill University opens a new door to understanding cancer
5. New study suggests Concord grape juice may provide protection against breast cancer
6. Preclinical study links gene to brain aneurysm formation
7. In limiting life span, study finds booming bacteria innocent
8. Multicenter study nets new lung tumor-suppressor gene
9. MIT study: Maturity brings richer memories
10. Chickadee, nutchatch presence in conifers increases tree growth, says CU-Boulder study
11. Phase II study of therapeutic vaccine shows efficacy in patients with metastatic colorectal cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2020)... ... June 24, 2020 , ... eClinical ... clinical data services that accelerate drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: ... in hospitalized patients with severe COVID-19. This is the first study of an ...
(Date:6/23/2020)... ... 2020 , ... The field of quantitation of large molecules or proteins has ... area. However, the use of mass spectrometry in this field has gained a lot ... do you choose which approach to use (LBA or MS)?” In many cases, ...
(Date:6/19/2020)... (PRWEB) , ... June 16, 2020 , ... The director ... is betting that if the stem cell medicine and pharmaceutical industries have easier access ... practice. So, starting July 5 of this year, Independence Day weekend in the ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... , ... August 13, 2020 , ... True Terpenes ... creation of its Scientific Advisory Board (SAB) to research the medical potential of terpenes ... be enhanced when combined with terpenes. The board is focused on expanding the recently ...
(Date:8/12/2020)... BINGHAM FARMS, Mich. (PRWEB) , ... August 12, ... ... International Consulting Group, Inc. (EMMA International), a global leader in FDA compliance ... ranking of the nation’s fastest-growing private companies. The list represents a unique look ...
(Date:7/31/2020)... Ariz. (PRWEB) , ... July 29, 2020 , ... R3 ... joint injections for only $3950. With 50 million stem cells total, patients may choose ... stem cell therapy works for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... leading global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, ... have entered into a strategic partnership whereby Catalent will provide support for the ...
Breaking Biology Technology:
Cached News: