HOME >> BIOLOGY >> NEWS
UCR involved in discovery of diabetes fighting molecule

University of California, Riverside Assistant Professor of Bioengineering, Jiayu Liao played a pivotal role in the discovery of a small molecule that has been shown to control diabetes in mice and may pave the way to the development of easier treatment for adult-onset diabetes.

This discovery was a collaboration between Liao at UC Riverside's Bourns College of Engineering and a team in the National Center for Drug Screening, Shanghai, which is part of the Chinese Academy of Science.

This key molecule, identified as Boc5, can stimulate insulin function in response to high levels of glucose as well as reduce body weight by 20 percent. The discovery of this molecule that stimulates the production of the intestinal hormone glucagon-like peptide1 (GLP1), which metabolizes glucose, has been an extremely difficult goal for researchers in both academics and the pharmaceutical industry.

Boc5 is the first small molecule activator for Class B GPCRs, which regulate hormones in many human physiological processes and are major targets for pharmaceutical companies. This discovery opened new revenue possibilities to support future research into small molecule interaction with Class B GPCRs in the future.

In the study, Liao and his colleagues were looking for ways to sensitize sugar-metabolizing insulin by stimulating production of GLP1. Synthetic versions of this peptide have proven effective but of short duration so it had been abandoned by drug researchers.

However, after Liao and his colleagues screened a library of more than 48,000 natural and synthetic compounds, they identified a molecule, Boc5, which mimics glucagon-like peptide1 in the blood leading to increases in insulin secretion in laboratory cultured rat pancreatic cells when exposed to high glucose levels. The molecule also worked when administered by injection and orally in experiments with laboratory mice.

Thus Boc5 behaved as full GLP1 mimic, both in th
'"/>

Contact: Ricardo Duran
ricardo.duran@ucr.edu
951-827-5893
University of California - Riverside
23-Jan-2007


Page: 1 2

Related biology news :

1. U-M researchers identify gene involved in breast cancer
2. Identified main genetic variants involved in response to HIV
3. Oregon researchers involved in new Clovis-age impact theory
4. LSU professor involved in genome sequencing of the first marsupial
5. Diseased brain cells more involved in ALS-associated motor neuron death
6. Researchers identify gene involved in dog size
7. UCLA identifies new molecule involved in the bodys processing of dietary fat
8. Gene controlling circadian rhythms may be involved in onset of bipolar disorder
9. Mechanisms involved with tumor relapse identified
10. Scientists find genes involved in the battle between Hessian flies and wheat
11. Pourqui lab identifies genes involved in formation of vertebral precursors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... N.J. , May 16, 2017  Veratad Technologies, ... provider of online age and identity verification solutions, announced ... K(NO)W Identity Conference 2017, May 15 thru May 17, ... Regan Building and International Trade Center. ... the globe and in today,s quickly evolving digital world, ...
(Date:4/24/2017)... April 24, 2017 Janice Kephart ... with  Identity Strategy Partners, LLP (IdSP) , today ... without President Trump,s March 6, 2017 Executive ... , refugee vetting can be instilled with greater confidence, ... now, all refugee applications are suspended by until ...
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. ... company, announces the filing of its 2016 Annual Report on Form ... Exchange Commission. ... Form 10-K is available in the Investor Relations section of the ... on the SEC,s website at http://www.sec.gov . 2016 ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ... its endogenous context, enabling overexpression experiments and avoiding the use of exogenous expression ... guides is transformative for performing systematic gain-of-function studies. , This complement to ...
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ... hosting a Webinar titled, “Pathology is going digital. Is your lab ready?” with ... adoption best practices and how Proscia improves lab economics and realizes an increase ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are the ... million people each year. Especially those living in larger cities are affected by air ... one of the most pollution-affected countries globally - decided to take action. , “I ...
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building and cooking ... initiative announced today. The bold new look is part of a transformation to ... into a significant growth period. , It will also expand its service offering from ...
Breaking Biology Technology:
Cached News: