HOME >> BIOLOGY >> NEWS
UCR involved in discovery of diabetes fighting molecule

University of California, Riverside Assistant Professor of Bioengineering, Jiayu Liao played a pivotal role in the discovery of a small molecule that has been shown to control diabetes in mice and may pave the way to the development of easier treatment for adult-onset diabetes.

This discovery was a collaboration between Liao at UC Riverside's Bourns College of Engineering and a team in the National Center for Drug Screening, Shanghai, which is part of the Chinese Academy of Science.

This key molecule, identified as Boc5, can stimulate insulin function in response to high levels of glucose as well as reduce body weight by 20 percent. The discovery of this molecule that stimulates the production of the intestinal hormone glucagon-like peptide1 (GLP1), which metabolizes glucose, has been an extremely difficult goal for researchers in both academics and the pharmaceutical industry.

Boc5 is the first small molecule activator for Class B GPCRs, which regulate hormones in many human physiological processes and are major targets for pharmaceutical companies. This discovery opened new revenue possibilities to support future research into small molecule interaction with Class B GPCRs in the future.

In the study, Liao and his colleagues were looking for ways to sensitize sugar-metabolizing insulin by stimulating production of GLP1. Synthetic versions of this peptide have proven effective but of short duration so it had been abandoned by drug researchers.

However, after Liao and his colleagues screened a library of more than 48,000 natural and synthetic compounds, they identified a molecule, Boc5, which mimics glucagon-like peptide1 in the blood leading to increases in insulin secretion in laboratory cultured rat pancreatic cells when exposed to high glucose levels. The molecule also worked when administered by injection and orally in experiments with laboratory mice.

Thus Boc5 behaved as full GLP1 mimic, both in th
'"/>

Contact: Ricardo Duran
ricardo.duran@ucr.edu
951-827-5893
University of California - Riverside
23-Jan-2007


Page: 1 2

Related biology news :

1. U-M researchers identify gene involved in breast cancer
2. Identified main genetic variants involved in response to HIV
3. Oregon researchers involved in new Clovis-age impact theory
4. LSU professor involved in genome sequencing of the first marsupial
5. Diseased brain cells more involved in ALS-associated motor neuron death
6. Researchers identify gene involved in dog size
7. UCLA identifies new molecule involved in the bodys processing of dietary fat
8. Gene controlling circadian rhythms may be involved in onset of bipolar disorder
9. Mechanisms involved with tumor relapse identified
10. Scientists find genes involved in the battle between Hessian flies and wheat
11. Pourqui lab identifies genes involved in formation of vertebral precursors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/13/2020)... ... June 11, 2020 , ... ... significant expansion of its forensic genealogy team. Bode’s Forensic Genealogy Service (FGS) ... forensic genealogy and DNA analysis methods. The team has added experienced genealogists, each ...
(Date:6/5/2020)... ... , ... “Although we are disappointed to have to make this decision our ... public. We remain committed to creating a global platform to showcase the science, ... President of WMIS. , The abstract deadline for the virtual meeting ...
(Date:5/28/2020)... ... ... CrucialTrak, a global designer and manufacturer of biometric access control systems, today announced that ... its complete line of biometric readers and access gates . CEG is a ... , Brett Mason, CrucialTrak’s Director of Channel Sales for the Americas is very excited ...
Breaking Biology News(10 mins):
(Date:6/28/2020)... , ... June 25, 2020 , ... ... advance photodynamic therapy for treating cancer, today announced the company has entered a ... Park”). The agreement provides Lumeda globally exclusive rights to Roswell Park intellectual ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... lab-made bioresearch materials, today announced the availability of the Delta-G-VSV Pseudotyping System for ... of Tennessee, enables studies of SARS-CoV-2 viral entry and COVID-19 vaccine effectiveness at ...
(Date:6/23/2020)... ... June 22, 2020 , ... Regen ... special offer. This includes buy three, get the fourth unit free with no ... Amniotic derived exosomes, known as exosomes, have been a game changer for regenerative ...
(Date:6/23/2020)... ... June 23, 2020 , ... Nobilis Therapeutics, a biopharmaceutical ... has filed an Investigational New Drug application (IND) with the U.S. Food & ... drug candidate NBTX-001 in patients with panic disorder (PD). , "Adding a PD ...
Breaking Biology Technology:
Cached News: