UCSB Neuroscience Research Institute: $1.25-million grant by Keck Foundation for Biomedical Research

The W. M. Keck Foundation's Medical Research Program has awarded UC Santa Barbara $1.25-million to support a pioneering multidisciplinary research initiative focusing on tiny RNA molecules-microRNAs-and their impact on the regulation of gene function.

"The scientific knowledge that is likely to emerge from the proposed work will be fundamental for a comprehensive and deep understanding of the biological pathway to therapeutics," said Kenneth Kosik, M.D., who will lead the project. Kosik is UCSB's Harriman Professor of Neuroscience Research and co-director of the Neuroscience Research Institute.

The UCSB research team will utilize recent breakthroughs to control the expression of any gene, including those that contribute to serious diseases such as cancer. In the past year, Kosik has published key findings that support the validity of using microRNAs as a treatment target.

Biologists had overlooked tiny RNA molecules for many years, but their recent discovery as key molecules in the regulation of gene function has electrified the biological community. Although many laboratories have validated the biological and potential therapeutic importance of microRNAs, UCSB is the only campus moving this technology to actual intervention, said Kosik, who is also a professor of molecular, cellular, and developmental biology.

Funding from the W. M. Keck Foundation will also support Keck Graduate Fellows and Keck Postgraduate Fellows who will work under the direction of six leading UCSB scientists. That research team includes Frank Doyle, Mellichamp Professor of Chemical Engineering; Samir Mitragotri, assistant professor of chemical engineering; Linda Petzold, professor of mechanical and environmental engineering; Joel Rothman, professor of molecular, cellular, and developmental biology; and Boris Shraiman, professor of physics and a permanent faculty member at the Kavli Institute for Theoretical Physics.


Contact: Eileen Conrad
University of California - Santa Barbara

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