HOME >> BIOLOGY >> NEWS
UCSD discovery opens new avenues for design of anti-tumor medications

The response of blood vessels to low oxygen levels may be the Achilles' heel of a developing tumor, according to a study led by University of California, San Diego biologists.

The study, published in the November 15 issue of the journal Cancer Cell, is the first to examine how blood vessels respond to the low oxygen conditions that result from the presence of a growing tumor. Previous work by the UCSD group and others has shown that tumors, which need a blood supply to provide oxygen and nutrients, release chemical signals that summon the blood vessels to grow toward them.

However, these latest findings show that the blood vessels themselves are actively responding to oxygen levels, not just to the signals sent by the tumor. According to the researchers, developing drugs that interfere with the blood vessels' response to low oxygen may be a potent anti-tumor strategy.

"We show that the blood vessels' response to lack of oxygen is just as important as the response of cancer cells to lack of oxygen," said Randall Johnson, a professor of biology at UCSD who headed the research team. "We identified a gene that turns on in the cells lining blood vessels when they are not getting enough oxygen and showed that without this gene the blood vessels cannot grow to nourish the developing tumor. Drugs that interfere with this gene, or another gene involved in the blood vessels' response, should block tumor growth."

The researchers showed that the gene, HIF-1alpha, is normally turned off in endothelial cells--the cells lining blood vessels. But when the endothelial cells are exposed to low oxygen conditions, such as those generated when a tumor is using up the oxygen supply, the gene becomes activated. By switching on other genes, HIF-1alpha causes the endothelial cells to proliferate and migrate.

In mice lacking HIF-1alpha in endothelial cells, blood vessels failed to grow to the tumors. Without blood vessels, the tum
'"/>

Contact: Kim McDonald
kmcdonald@ucsd.edu
858-534-7572
University of California - San Diego
15-Nov-2004


Page: 1 2 3

Related biology news :

1. Enzyme discovery sheds light on vitamin D
2. New proteomics research promises to revolutionize biomedical discovery
3. MU researchers make discovery in molecular mechanics of phototropism
4. International team to honor 30th anniversary of deep-sea vent discovery in Galpagos
5. Screening approach leads to discovery of gene linked to breast cancer
6. Lucky 13 as new gene discovery offers further hope for childhood blindness
7. Plants that produce more vitamin C may result from UCLA-Dartmouth discovery
8. Biting discovery: MU entomologist finds host of new aquatic insect species in Thailand
9. J&JPRD discovery may lead to new treatments for chronic sensitivity, pain caused by cold
10. Protein enables discovery of quantum effect in photosynthesis
11. Unicellular microRNA discovery

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/24/2019)... ... July 24, 2019 , ... ... PhD, a quality assurance expert with more than 20 years of experience working ... products, has joined the firm as an Expert Consultant. , Dr. Hartzfeld has ...
(Date:7/23/2019)... ... , ... NanoFUSE is pleased to announce the ... spine and orthopedic use. Bioactive glass is a calcium phosphate coated silica that ... orthopedics for over 30 years and now NanoFUSE Biologics has used advanced research ...
(Date:7/19/2019)... ... July 19, 2019 , ... ... Amorphous and Crystalline States – Insights from Synchrotron X-ray Pair Distribution (SXPDF) Studies”. ... along with Chris Benmore of Argonne National Laboratory and Gabriel de Araujo of ...
Breaking Biology News(10 mins):
(Date:8/6/2019)... ... August 05, 2019 , ... ... has been recognized as a distinguished leader by PharmaVOICE magazine, earning him a ... article in the magazine’s July/August special issue. , As the executive vice president ...
(Date:7/26/2019)... (PRWEB) , ... July 25, 2019 , ... ... biopharma leaders through off-the-record collaboration and dialogue, today announces its Boston BD ... Waterfront Hotel. As part of Biotech Week Boston , the event provides ...
(Date:7/17/2019)... ... July 15, 2019 , ... CRISPR is often thought ... certain trait can be removed, replaced, or edited, but Yiping Qi, assistant professor in ... these traditional applications in his latest publication in Nature Plants. In this comprehensive review, ...
(Date:7/9/2019)... ... 08, 2019 , ... Today, at the BIO World Congress on ... (NCGA) announced the winners of the Consider Corn Challenge II. Three winners were ... corn to produce biobased materials. , “Corn is a sustainable, abundant and affordable ...
Breaking Biology Technology:
Cached News: