HOME >> BIOLOGY >> NEWS
UCSD discovery opens new avenues for design of anti-tumor medications

ors were starved of oxygen and nutrients, resulting in tumors were smaller in size than in normal mice and had dead tissue at their centers.

To date, most efforts to develop angiogenesis inhibitors--drugs to prevent growth of blood vessels-- have focused on inhibiting the signals sent out by the tumor in response to low oxygen. These latest findings suggest that targeting the endothelial cells' response to low oxygen is a viable alternative strategy to the development of angiogenesis inhibitors. Furthermore, the researchers point out that it may be easier to design effective treatments that target the endothelial cells rather than the tumor cells.

"Cancer cells mutate frequently," says Nan Tang, a graduate student working with Johnson and the first author on the paper. "This means that it is common for these cells to develop resistance to drugs. On the other hand, the endothelial cells are normal cells and would be much less likely to develop drug resistance."

"The endothelial cells are also in direct contact with the blood, simplifying the delivery of drugs," adds Tang.

Because HIF-1alpha is usually turned off in endothelial cells, and the mice lacking the gene in blood vessels were healthy and had normal lifespans, the researchers think that inhibiting the blood vessels' response to low oxygen should be relatively safe. One caveat is that interfering with blood vessels' response to low oxygen may also inhibit wound healing, as was observed in the mice lacking HIF-1alpha. According to the researchers, further work will be needed before their discovery can be applied to actually design new anti-tumor drugs.

"Since the response of the blood vessels to low oxygen likely involves multiple genes and chemical signals, we still need to tease apart the steps involved in the response," says Johnson. "It will also be important to understand how the signals sent out by the tumor, to stimulate t
'"/>

Contact: Kim McDonald
kmcdonald@ucsd.edu
858-534-7572
University of California - San Diego
15-Nov-2004


Page: 1 2 3

Related biology news :

1. Enzyme discovery sheds light on vitamin D
2. New proteomics research promises to revolutionize biomedical discovery
3. MU researchers make discovery in molecular mechanics of phototropism
4. International team to honor 30th anniversary of deep-sea vent discovery in Galpagos
5. Screening approach leads to discovery of gene linked to breast cancer
6. Lucky 13 as new gene discovery offers further hope for childhood blindness
7. Plants that produce more vitamin C may result from UCLA-Dartmouth discovery
8. Biting discovery: MU entomologist finds host of new aquatic insect species in Thailand
9. J&JPRD discovery may lead to new treatments for chronic sensitivity, pain caused by cold
10. Protein enables discovery of quantum effect in photosynthesis
11. Unicellular microRNA discovery

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UCSD discovery opens new avenues for design anti tumor medications

(Date:10/17/2014)... is critical and pertinent for practicing physicians and clinicians ... epidemic. The Journal, Disaster Medicine and Public Health ... and Public Health, to surround the public, medical professionals ... moment. , On October 17, the journal published ... primer was prepared by Dr. Eric Toner, internist and ...
(Date:10/16/2014)... the human body. Battles are won, lost or ... this stalemate—known as tumor dormancy—can last up to ... that is poorly understood. , A new ... Torquato, a Professor of Chemistry at Princeton University, ... and the switch to a malignant state. Published ...
(Date:10/16/2014)... can be cultivated efficiently, they are anything but ... by monoculture cultivation is becoming increasingly evident. Despite ... form and are regarded as the sole possibility ... quite wrongfully, finds Bernhard Schmid, an ecology professor ... novel form of agriculture and forestry. After all, ...
Breaking Biology News(10 mins):Modeling tumor dormancy 2Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
(Date:10/18/2014)... The Asian Electronic Medical Record (EMR) market ... analysis and forecast of revenue. The electronic medical record market ... million by 2018, at a CAGR of 9.4% from 2013 ... Electronic Medical Record (EMR) market, to get an idea of ... the segmentation of the market in the same region, and ...
(Date:10/18/2014)... 18, 2014 The “Global Diagnostic ... Monitor), by End-user (Hospitals, Home/Ambulatory, Research Center, Physician ... 12) -Global Forecast to 2020” provides a detailed ... current market trends, and strategies impacting the global ... forecasts of the revenue and share analysis. , ...
(Date:10/17/2014)... October 17, 2014 For the ... employers, as published in today’s print issue of ... annual Top Employers Survey polled employees in the ... 20 best employers. Rankings were determined based ... to rate their companies on 23 characteristics, including ...
(Date:10/17/2014)... Europe Fuel Additives Market report defines and segments the ... of revenue. , Browse through the TOC of the ... of the in-depth analysis provided. This also provides a ... market, and is supported by various tables and figures. ... chemicals that are used to enhance the properties of ...
Breaking Biology Technology:The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 2The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 3The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 5The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 2The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 3The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 4The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 5DuPont Named Top Employer by Science Magazine 2DuPont Named Top Employer by Science Magazine 3The Europe Fuel Additives Market is estimated to grow to $1,401.4 million by 2018 - New Report by MicroMarket Monitor 2The Europe Fuel Additives Market is estimated to grow to $1,401.4 million by 2018 - New Report by MicroMarket Monitor 3The Europe Fuel Additives Market is estimated to grow to $1,401.4 million by 2018 - New Report by MicroMarket Monitor 4
Cached News: