HOME >> BIOLOGY >> NEWS
UCSD discovery shows how embryonic stem cells perform 'quality control' inspections

Biologists at the University of California, San Diego have found a fundamental mechanism used by embryonic stem cells to assure that genetically damaged stem cells do not divide and pass along the damage to daughter stem cells.

Their discovery, detailed in an advance online publication of the journal Nature Cell Biology, solves the longstanding mystery of how embryonic stem cells, which have the potential to divide an unlimited number of times and differentiate to make all of the cell types in the body, are able to avoid duplicating cells that have sustained genetic damage.

"What we discovered is a primary mechanism that allows embryonic stem cells to perform quality control inspections during their self-renewal, the process by which these cells undergo unlimited cellular division to produce an unlimited number of daughter cells," says Yang Xu, an associate professor of biology at UCSD who headed the research team.

"Since DNA damage can occur during normal cellular propagation as well as after the exposure of cells to DNA-damaging radiation and chemicals, it is critical for the embryonic stem cells to develop stringent mechanisms to ensure the repair of DNA damage and prevent the passage of DNA damage to their daughter cells. Unrepaired DNA damage will cause genetic instability and, ultimately, cellular transformation into cancer cells."

Xu and his team made their discovery while working with embryonic stem cell lines from mice, which possess the same known properties and capabilities as human embryonic stem cells. They found that a protein, p53, known to play a critical role in the suppression of tumors in both humans and mice, is also used to maintain the genetic stability of embryonic stem cells.

The scientists, who included Tongxiang Lin, a UCSD postdoctoral fellow and the first author of the study, and Connie Chao, a graduate student in Xu's laboratory, discovered that p53 activated by DNA damage in mouse em
'"/>

Contact: Yang Xu
yangxu@ucsd.edu
858 822-1084
University of California - San Diego
26-Dec-2004


Page: 1 2

Related biology news :

1. Enzyme discovery sheds light on vitamin D
2. New proteomics research promises to revolutionize biomedical discovery
3. MU researchers make discovery in molecular mechanics of phototropism
4. International team to honor 30th anniversary of deep-sea vent discovery in Galpagos
5. Screening approach leads to discovery of gene linked to breast cancer
6. Lucky 13 as new gene discovery offers further hope for childhood blindness
7. Plants that produce more vitamin C may result from UCLA-Dartmouth discovery
8. Biting discovery: MU entomologist finds host of new aquatic insect species in Thailand
9. J&JPRD discovery may lead to new treatments for chronic sensitivity, pain caused by cold
10. Protein enables discovery of quantum effect in photosynthesis
11. Unicellular microRNA discovery

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2017)... 2017 NXT-ID, Inc. (NASDAQ: NXTD ) ... of its 2016 Annual Report on Form 10-K on Thursday April ... ... in the Investor Relations section of the Company,s website at ... at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... DUBLIN , Apr. 11, 2017 Research ... Tracking Market 2017-2021" report to their offering. ... The global eye tracking market to grow at ... The report, Global Eye Tracking Market 2017-2021, has been prepared based ... report covers the market landscape and its growth prospects over the ...
(Date:4/5/2017)... 2017  The Allen Institute for Cell Science today ... one-of-a-kind portal and dynamic digital window into the human ... first application of deep learning to create predictive models ... and a growing suite of powerful tools. The Allen ... future publicly available resources created and shared by the ...
Breaking Biology News(10 mins):
(Date:7/18/2017)... ... July 18, 2017 , ... G-CON ... Patent and Trademark Office for its Patent Applications 14/858,857 and 13/669,785 both entitled ... these patent applications further expand the protection of G-CON’s R&D investments and validate ...
(Date:7/17/2017)... , ... July 17, 2017 , ... The Academy of ... celebration of National Model Aviation Day will take place from 9 a.m. to 2 ... will include activities for all ages. , Aviation Adventure Day will be packed with ...
(Date:7/17/2017)... Utah (PRWEB) , ... July 17, 2017 , ... ... molecular diagnostics company that has developed and intends both to manufacture and sell ... trading on the NASDAQ Capital Market. , Headquartered in Sandy, Utah, Co-Diagnostics’ intellectual ...
(Date:7/14/2017)... ... July 14, 2017 , ... Sonic Manufacturing ... Manufacturing Technologies has installed a solar system on its roof top. “We will ... President of Sonic, Kenneth Raab stated. The company’s proud history of social responsibility ...
Breaking Biology Technology:
Cached News: