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UCSD medical researchers discover molecular pathway that turns a juvenile heart into an adult heart

Researchers at the University of California, San Diego (UCSD) School of Medicine have discovered the molecular sequence of events in mice that turn a juvenile heart into an adult heart capable of responding to increased workloads.

Published as the cover story in the January 14, 2005 issue of the journal Cell, the study identifies a protein called ASF/SF2 as a regulator of a calcium enzyme responsible for heart contraction and tissue growth. Mice born with mutated or absent ASF/SF2 had shortened contractive fiber that appeared locked in a contracted state, leading to sudden death. When ASF/SF2 was normal, heart development progressed normally.

"The cascade of molecular events that we have uncovered are directly relevant to understanding heart physiology during development, and may provide insights into mechanisms that directly contribute to heart attacks in humans," said the study's senior author, Xiang-Dong Fu, Ph.D., a UCSD professor of Cellular and Molecular Medicine.

ASF/SF2 are part of a family of proteins that function in a vital cellular process called alternative splicing the mechanism through which a single gene can generate several kinds of proteins by selecting different combinations of the same set of amino acid building blocks. Alternative splicing occurs at all stages of development, including the period of transition from juvenile to adult life, when many tissues and organs, such as the heart, become mature. Although alternative splicing is widely known, little is understood about how this process occurs in mammals. In a "Preview" appearing in the January 14, 2005 issue of Cell, Thomas A. Cooper of the Departments of Pathology and Molecular and Cellular Biology at Baylor College of Medicine in Houston, noted that the results by Fu's team "highlight the huge potential and largely unexplored role for alternative splicing during vertebrate development."

The UCSD researchers used mouse models and sophistic
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Contact: Sue Pondrom
spondrom@ucsd.edu
619-543-6163
University of California - San Diego
13-Jan-2005


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