HOME >> BIOLOGY >> NEWS
UCSF stem cell study reveals cells' capability in mouse brain tissue repair

UCSF scientists have determined that adult stem cells in a specific region of the mouse brain have a built-in mechanism that allows the cells to participate in the repair and remodeling of damaged tissue in the region.

As the cells are also present in the human brain, the same capacity or potential may exist in humans, the researchers say. If they do, it is possible that the cells behavior could be enhanced to treat tissues damaged throughout the brain by disorders such as stroke and traumatic injury.

The study, reported in the December 15 issue of Cell, was led by Chay T. Kuo, MD, PhD, a UCSF postdoctoral fellow in the laboratory of senior investigator Yuh-Nung Jan, PhD.

Kuo is one of 16 UCSF CIRM Stem Cell Scholars up and coming young scientists funded by the California Institute for Regeneration Medicine, established by California voters in 2004 to allocate $3 billion over 10 years to support stem cell research.

"The results were very surprising," says Kuo. "Our results show that neural stem cells in mice have the ability to sense damage in their environment that leads to their subsequent proliferation to help restore local tissue integrity. If we can figure out how this happens, and determine that it occurs in human neural stem cells, we may be able to increase the effect and harness it for therapeutic use."

Understanding this proliferative capacity during environmental change is critical, he says, as adult neural stem cells in this region may sometimes proliferate out of control to form brain tumors. This possibility has been reported and is being explored by scientists in the UCSF Institute for Regeneration Medicine and UCSF Department of Neurological Surgery.

The scientists focused their study on postnatal neural stem cells that lie next to the lining of the brains lateral ventricles, or cavity, in a region known as the subventricular zone (SVZ). In 1999, the lab of study co-author Arturo Alvar
'"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
14-Dec-2006


Page: 1 2 3 4

Related biology news :

1. New study warns limited carbon market puts 20 percent of tropical forest at risk
2. Clones on task serve greater good, evolutionary study shows
3. Pollution causes 40 percent of deaths worldwide, study finds
4. A study by the MUHC and McGill University opens a new door to understanding cancer
5. New study suggests Concord grape juice may provide protection against breast cancer
6. Preclinical study links gene to brain aneurysm formation
7. In limiting life span, study finds booming bacteria innocent
8. Multicenter study nets new lung tumor-suppressor gene
9. MIT study: Maturity brings richer memories
10. Chickadee, nutchatch presence in conifers increases tree growth, says CU-Boulder study
11. Phase II study of therapeutic vaccine shows efficacy in patients with metastatic colorectal cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: