HOME >> BIOLOGY >> NEWS
UF, Columbia scientists closer to new cancer detection method

ect a molecule that coexists with many other molecules, you have to sort through the signals from the other molecules," Tan said. "This technique solves the problem caused by background signals from both the probe and the biological fluids where the proteins reside. We have engineered a molecular switch that turns on the fluorescence."

The probe's green fluorescent burst lasts little more than a billionth of a second - a nanosecond - but just long enough to separate it from surrounding signals, according to co-author Nicholas Turro, Ph.D., the William P. Schweitzer professor of chemistry at Columbia University. He also holds professorships in the department of chemical engineering and the department of earth and environmental engineering.

"A cell contains a lot of material that absorbs and emits light when it's excited," Turro said. "That's been the problem. However, if you wait 10 nanoseconds, the signals from the native fluorescence go away. What's left is the signal from the probe, which is engineered to be more long-lived at about 50 nanoseconds."

The result is a clear indication of the presence of PDGF.

"The problem of background signals is a major obstacle in many of these biodetection methods," said Paras N. Prasad, Ph.D., a distinguished professor of chemistry and executive director of the Institute for Lasers, Photonics and Biophotonics at the University of Buffalo. "Dr. Tan and his colleagues were able to address that with their light-switching method. This is a significant advancement in minimizing a frequent problem."

Much work remains to be done, but the technique potentially could be a diagnostic tool for cancer and other diseases. It could also be used to detect illicit drugs, such as cocaine, in the body, researchers say.

"Eventually we would like to see this assay become as convenient as a pregnancy test," said Chaoyong James Yang, a chemistry doctoral student in the Tan group and the first author of t
'"/>

Contact: John Pastor
jpastor@vpha.health.ufl.edu
352-273-5815
University of Florida
29-Nov-2005


Page: 1 2 3

Related biology news :

1. Columbia University Medical Center awarded $3 million to drive Alzheimers genetics research
2. Columbia scientists determine 3-dimensional structure of cells fuel gauge
3. Columbia University licenses next-generation DNA sequencing technology
4. New bird discovered on unexplored Columbian mountain
5. Columbia University Medical Center receives major new NIH Clinical Science investment funds
6. Columbia University awards 2006 Horwitz Prize to biologist who explained gene transcription
7. Columbia University receives $16.9 million NIEHS award to study arsenic in ground water
8. Contaminants linked to sturgeon decline in Columbia river
9. Columbia University Medical Center researchers discover potential mechanism for tumor growth
10. Columbia University awards 2005 Horwitz Prize to Israeli structural biologist
11. Columbia wins major grant to examine genetic link to Alzheimers Disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2016)... NEW YORK , May 16, 2016   ... authentication solutions, today announced the opening of an IoT ... to strengthen and expand the development of embedded ... provides an unprecedented level of convenience and security with ... to authenticate one,s identity aside from DNA. EyeLock,s platform ...
(Date:4/28/2016)... , April 28, 2016 First quarter 2016: ... up 966% compared with the first quarter of 2015 ... SEK 589.1 M (loss: 18.8) and the operating margin was 40% ... 0.32) Cash flow from operations was SEK 249.9 M ... revenue guidance is unchanged, SEK 7,000-8,500 M. The operating ...
(Date:4/15/2016)... 2016 Research and Markets has ... Market 2016-2020,"  report to their offering.  , ... ,The global gait biometrics market is expected to ... period 2016-2020. Gait analysis generates multiple ... used to compute factors that are not or ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016  Sequenom, Inc. (NASDAQ: SQNM ... lives through the development of innovative products and services, ... the United States denied its petition to ... of Sequenom,s U.S. Patent No. 6,258,540 (",540 Patent") are ... by the Supreme Court,s Mayo Collaborative Services v. Prometheus ...
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , the leading software ... Clinical Reach Virtual Patient Encounter CONSULT module which enables both audio and ... clinical trial team. , Using the CONSULT module, patients and physicians can schedule a ...
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... operations for Amgen, will join the faculty of the University of North ... adjunct professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on ...
(Date:6/27/2016)... --  Ginkgo Bioworks , a leading organism design ... awarded as one of the World Economic Forum,s ... innovative companies. Ginkgo Bioworks is engineering biology to ... in the nutrition, health and consumer goods sectors. ... including Fortune 500 companies to design microbes for ...
Breaking Biology Technology:
Cached News: