HOME >> BIOLOGY >> NEWS
UF, Columbia scientists closer to new cancer detection method

ect a molecule that coexists with many other molecules, you have to sort through the signals from the other molecules," Tan said. "This technique solves the problem caused by background signals from both the probe and the biological fluids where the proteins reside. We have engineered a molecular switch that turns on the fluorescence."

The probe's green fluorescent burst lasts little more than a billionth of a second - a nanosecond - but just long enough to separate it from surrounding signals, according to co-author Nicholas Turro, Ph.D., the William P. Schweitzer professor of chemistry at Columbia University. He also holds professorships in the department of chemical engineering and the department of earth and environmental engineering.

"A cell contains a lot of material that absorbs and emits light when it's excited," Turro said. "That's been the problem. However, if you wait 10 nanoseconds, the signals from the native fluorescence go away. What's left is the signal from the probe, which is engineered to be more long-lived at about 50 nanoseconds."

The result is a clear indication of the presence of PDGF.

"The problem of background signals is a major obstacle in many of these biodetection methods," said Paras N. Prasad, Ph.D., a distinguished professor of chemistry and executive director of the Institute for Lasers, Photonics and Biophotonics at the University of Buffalo. "Dr. Tan and his colleagues were able to address that with their light-switching method. This is a significant advancement in minimizing a frequent problem."

Much work remains to be done, but the technique potentially could be a diagnostic tool for cancer and other diseases. It could also be used to detect illicit drugs, such as cocaine, in the body, researchers say.

"Eventually we would like to see this assay become as convenient as a pregnancy test," said Chaoyong James Yang, a chemistry doctoral student in the Tan group and the first author of t
'"/>

Contact: John Pastor
jpastor@vpha.health.ufl.edu
352-273-5815
University of Florida
29-Nov-2005


Page: 1 2 3

Related biology news :

1. Columbia University Medical Center awarded $3 million to drive Alzheimers genetics research
2. Columbia scientists determine 3-dimensional structure of cells fuel gauge
3. Columbia University licenses next-generation DNA sequencing technology
4. New bird discovered on unexplored Columbian mountain
5. Columbia University Medical Center receives major new NIH Clinical Science investment funds
6. Columbia University awards 2006 Horwitz Prize to biologist who explained gene transcription
7. Columbia University receives $16.9 million NIEHS award to study arsenic in ground water
8. Contaminants linked to sturgeon decline in Columbia river
9. Columbia University Medical Center researchers discover potential mechanism for tumor growth
10. Columbia University awards 2005 Horwitz Prize to Israeli structural biologist
11. Columbia wins major grant to examine genetic link to Alzheimers Disease

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Columbia scientists closer new cancer detection method

(Date:10/16/2014)... have challenged conventional thinking on how the bowel lining ... for how bowel cancer starts. , The researchers produced ... regenerating the ,crypts, that are a feature of the ... in bowel cancer development, a controversial finding as scientists ... Using 3D imaging technologies, Dr Chin Wee Tan and ...
(Date:10/16/2014)... causes severe respiratory tract infections and worldwide claims ... at VIB and Ghent University have succeeded in ... common virus infection. , Xavier Saelens (VIB/UGent): ... the way for the development of a novel ... causes suffering in numerous small children and elderly ...
(Date:10/16/2014)... -- NXT-ID, Inc. (NASDAQ: NXTD and ... focused on the growing mobile commerce market announces that ... Smart Wallet, at the 13 th annual Future ... conference on the intersection of technology and the economy. ... founder and publisher of the Strategic News Service™, the ...
Breaking Biology News(10 mins):Cryptic clues drive new theory of bowel cancer development 2New perspectives for development of an RSV vaccine 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3
(Date:10/19/2014)... 2014 The Latin American hardware encryption ... Latin America with analysis and forecast of revenue. This ... is expected to reach $2,366.8 million by 2018, at ... Browse through the TOC of the Latin American hardware ... in-depth analysis provided. It also provides a glimpse of ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The Asian ... in Asian with analysis and forecast of revenue. The ... grow to around $463.9 million by 2018, at a ... Browse through the TOC of the Asian Automatic patient ... analysis provided. This also provides a glimpse of the ...
(Date:10/19/2014)... October 19, 2014 The report ... & Homeland Security), Technology, Payload, Type & by ... segments the global unmanned ground vehicle market into ... forecasting of market sizes. The report also identifies ... opportunities impacting it along with the adoption trends. ...
(Date:10/18/2014)... The report "1,6-Hexanediol Market by Application ... 2019", analyzes the global market on the basis ... industry details such as the key drivers, current ... , Browse 81 Market Data Tables and 29 ... on “1,6-Hexanediol Market by Application and by Geography ...
Breaking Biology Technology:The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 51,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5
Cached News: