HOME >> BIOLOGY >> NEWS
UF, Columbia scientists closer to new cancer detection method

ect a molecule that coexists with many other molecules, you have to sort through the signals from the other molecules," Tan said. "This technique solves the problem caused by background signals from both the probe and the biological fluids where the proteins reside. We have engineered a molecular switch that turns on the fluorescence."

The probe's green fluorescent burst lasts little more than a billionth of a second - a nanosecond - but just long enough to separate it from surrounding signals, according to co-author Nicholas Turro, Ph.D., the William P. Schweitzer professor of chemistry at Columbia University. He also holds professorships in the department of chemical engineering and the department of earth and environmental engineering.

"A cell contains a lot of material that absorbs and emits light when it's excited," Turro said. "That's been the problem. However, if you wait 10 nanoseconds, the signals from the native fluorescence go away. What's left is the signal from the probe, which is engineered to be more long-lived at about 50 nanoseconds."

The result is a clear indication of the presence of PDGF.

"The problem of background signals is a major obstacle in many of these biodetection methods," said Paras N. Prasad, Ph.D., a distinguished professor of chemistry and executive director of the Institute for Lasers, Photonics and Biophotonics at the University of Buffalo. "Dr. Tan and his colleagues were able to address that with their light-switching method. This is a significant advancement in minimizing a frequent problem."

Much work remains to be done, but the technique potentially could be a diagnostic tool for cancer and other diseases. It could also be used to detect illicit drugs, such as cocaine, in the body, researchers say.

"Eventually we would like to see this assay become as convenient as a pregnancy test," said Chaoyong James Yang, a chemistry doctoral student in the Tan group and the first author of t
'"/>

Contact: John Pastor
jpastor@vpha.health.ufl.edu
352-273-5815
University of Florida
29-Nov-2005


Page: 1 2 3

Related biology news :

1. Columbia University Medical Center awarded $3 million to drive Alzheimers genetics research
2. Columbia scientists determine 3-dimensional structure of cells fuel gauge
3. Columbia University licenses next-generation DNA sequencing technology
4. New bird discovered on unexplored Columbian mountain
5. Columbia University Medical Center receives major new NIH Clinical Science investment funds
6. Columbia University awards 2006 Horwitz Prize to biologist who explained gene transcription
7. Columbia University receives $16.9 million NIEHS award to study arsenic in ground water
8. Contaminants linked to sturgeon decline in Columbia river
9. Columbia University Medical Center researchers discover potential mechanism for tumor growth
10. Columbia University awards 2005 Horwitz Prize to Israeli structural biologist
11. Columbia wins major grant to examine genetic link to Alzheimers Disease

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Columbia scientists closer new cancer detection method

(Date:7/30/2014)... been awarded the Scientific Committee on Antarctic Research,s ... , SCAR, an inter-disciplinary international science body, initiates, ... in the Antarctic region, and on the role ... The organisation also provides scientific advice about Antarctica ... the region. , The medal is open internationally ...
(Date:7/30/2014)... the roughly 3,000 pieces is still in its infant ... will be of major significance. "Amazingly often, we are ... Fushun amber that we found in Baltic amber," explained ... Baltic amber comes from the Baltic Sea region, which ... finds are, e.g., the coastal regions of Mecklenburg, Poland ...
(Date:7/29/2014)... BELLINGHAM, Washington, USA The advanced optical methods and ... are driving a revolution in the neurosciences were the ... published by SPIE, the international society for optics and ... of the BRAIN Initiative in the United States, and ... vision for and provide examples of the impact that ...
Breaking Biology News(10 mins):Chinese mosquitos on the Baltic Sea 2SPIE launches Neurophotonics journal with special section on BRAIN Initiative 2SPIE launches Neurophotonics journal with special section on BRAIN Initiative 3
(Date:7/30/2014)... (PRWEB) July 30, 2014 While ... in health services research for a relatively long ... in interest regarding the use of these ‘big ... conditions. , By combining today’s powerful computer technology ... digital era, ‘big data’ holds significant promise for ...
(Date:7/30/2014)... July 30, 2014 July 30, 2014. ... a biotechnology firm that provides DNA-based authentication and security ... Ph.D. Vice President of Life Sciences, a newly created ... , Dr. Hogan will lead APDN’s drive to build ... with biotech and healthcare customers, provide guidance to APDN’s ...
(Date:7/30/2014)... July 30, 2014  Dyadic International, Inc. ("Dyadic") ... patented and proprietary technologies are used to discover, ... for the bioenergy, bio-based chemical, biopharmaceutical and industrial ... "Tom" Dubinski as Vice President and Chief Financial ... financial and information technology operations for Dyadic and ...
(Date:7/30/2014)... NCERC at Southern Illinois University Edwardsville ... on corn stover pretreatment methods at a U.S. ... D.C. , “Arun’s selection for presentation at ... to the success of our postdoctoral fellowship program,” ... foresight and vision of SIUE and the Illinois ...
Breaking Biology Technology:Leveraging ‘Big Data’ - Methodological Considerations in Health Services Research, New Webinar Hosted by Xtalks 2Dr. Michael E. Hogan, Ph.D., Joins Applied DNA Sciences as Vice President, Life Sciences 2Dr. Michael E. Hogan, Ph.D., Joins Applied DNA Sciences as Vice President, Life Sciences 3Thomas Dubinski joins Dyadic as Chief Financial Officer 2Thomas Dubinski joins Dyadic as Chief Financial Officer 3Thomas Dubinski joins Dyadic as Chief Financial Officer 4NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 2NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 3
Cached News: