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USC-led team of scientists recreates DNA-mending pathway in test-tube

n essential part of this research team.

"Before this, no one knew what this class was good for," Lieber explains. "This is really the first solid indication of what two of these polymerases might do."

Knowledge of the details of the NHEJ pathway extends beyond its connections to cancer and radiation treatment, Lieber notes.

"This pathway gets used not just for accidental damage, oxidative damage and radiation damage to DNA, but is also used in the immune system," he explains. "So the immune system would function less well without it."


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Contact: Jon Weiner
jon.weiner@usc.edu
323-442-2830
University of Southern California
2-Dec-2004


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