HOME >> BIOLOGY >> NEWS
UT Southwestern researchers uncover process for sugar-induced fat formation

DALLAS Oct. 18, 2004 Researchers at UT Southwestern Medical Center at Dallas are one step closer to understanding how high carbohydrate diets lead to obesity and diabetes.

Dr. Kosaku Uyeda, professor of biochemistry, has shown that a single protein called carbohydrate response element binding protein (ChREBP), discovered by his research group, activates several genes that cause cells in the liver to turn sugar into fat.

Their work appears in two studies in Proceedings of the National Academy of Sciences. The first study, published in an earlier issue, is available online, and the second, also online, will appear in an upcoming issue of PNAS.

"Purifying ChREBP from rat livers took two postdoctoral fellows two years of very hard work," said Dr. Uyeda, senior author of both studies and a research scientist at the Veterans Affairs North Texas Health Care System. "With the discovery of this factor, the biochemical mechanism of how carbohydrates are converted to fat has become clearer."

Eating meals high in carbohydrates or sugars leads the body to do several things. Some of the sugars are immediately converted to energy while the rest of the sugars are converted to fat. The sugar-to-fat conversion occurs two ways an immediate response, where enzymes are mobilized to rapidly convert sugars into fat; and a slower response, in which several different genes are turned on and off, creating more enzymes that can also turn sugar into fat. ChREBP is involved in the slow response.

ChREBP is a type of protein called a transcription factor. Transcription factors work in the cell nucleus to turn genes on and off in response to a signal. In the case of ChREBP, the signal is glucose, a simple sugar formed when carbohydrates are broken down during digestion. Glucose enters the bloodstream and, through transport molecules, enters cells where it is broken down into even smaller pieces. These smaller pieces are diverted from th
'"/>

Contact: Megha Satyanarayana
megha.saty@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
18-Oct-2004


Page: 1 2 3

Related biology news :

1. UT Southwestern joins national clinical trial to uncover long-term effects of West Nile virus
2. UT Southwestern leaders to receive national award for medical research accomplishments
3. UT Southwestern scientist receives NIH Directors Pioneer Award
4. UT Southwestern scientist named Keck Foundation Distinguished Young Scholar in Medical Research
5. UT Southwestern researchers find gene mutation that leads to broken hearts
6. Plague agent helps UT Southwestern researchers find novel signaling system in cells
7. One of the nations first 7-Tesla magnetic resonance imaging devices for human studies planned at UT Southwestern Medical Center
8. DNA end caps may lead to cancer treatments, UT Southwestern researchers report
9. UT Southwestern scientist honored among best in Texas research
10. UT Southwestern scientist receives international award for pediatric research
11. UT Southwestern physician-researcher wins international award for lipid research

Post Your Comments:
(Date:3/17/2015)... , March 17, 2015 ... company specializing in clinical study management systems, is ... in attendance at ARENA,s Outsourcing in Clinical Trials ... This event provides an excellent forum for MedNet ... flexible and affordable software-as-a-service (SaaS) eClinical technology platform. ...
(Date:3/12/2015)... Va. , March 12, 2015 IriTech, ... and a member of the Texas Instruments Design Network, ... Naidu has demonstrated its IriShield USB MK2120U device ... scanning facility for pension distribution. The ... assembled to be marketed in India ...
(Date:3/11/2015)... Research and Markets ( http://www.researchandmarkets.com/research/3p32qm/access_control ) ... Market by Product, Application & By Geography - Global ... offering. , This report predicts that the ... by 2020, with an estimated CAGR of 10.6%. ... types such as contact cards & readers, contactless cards ...
Breaking Biology News(10 mins):Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2
(Date:3/29/2015)... Texas , March 29, 2015 /PRNewswire/ ... presentation of important study data showing the ... in 1,599 gynecologic cancer samples. Using Caris ... profiling service, researchers identified expression of programmed ... cancers independent of histology while its ligand ...
(Date:3/27/2015)... 2015  Neogen Corporation (NASDAQ: NEOG ) announced ... trading plan in accordance with Securities and Exchange Commission ... of Neogen Corporation, is a minority owner of this ... Herbert does not have control of this ... is only for a portion of the shares owned ...
(Date:3/27/2015)... ROCKVILLE, Md. , March 27, 2015  CASI ... dedicated to the acquisition, development and commercialization of innovative ... the global market with a commercial focus on ... the three and 12 months ended December 31, 2014.  ... of ($1.6 million), or ($0.05) per share, for the ...
(Date:3/26/2015)... The Market Element LLC, a leading inbound ... Designing Gig LLC to provide website design, development, and ... this alliance with Designing Gig represents a pivotal moment ... comprehensive, end-to-end, digital solution for our clients, which now ... Miller, president of The Market Element. “For small and ...
Breaking Biology Technology:Caris Life Sciences' Multiplatform Tumor Profiling Technology Identifies Expression of PD-1 and PD-L1 in Gynecologic Malignancies 2Caris Life Sciences' Multiplatform Tumor Profiling Technology Identifies Expression of PD-1 and PD-L1 in Gynecologic Malignancies 3Caris Life Sciences' Multiplatform Tumor Profiling Technology Identifies Expression of PD-1 and PD-L1 in Gynecologic Malignancies 4Neogen CEO adopts 10b5-1 Trading Plan 2CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 2CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 3CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 4CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 5CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 6The Market Element LLC and Designing Gig LLC Form Strategic Alliance 2
Cached News: