HOME >> BIOLOGY >> NEWS
UT Southwestern researchers uncover process for sugar-induced fat formation

DALLAS Oct. 18, 2004 Researchers at UT Southwestern Medical Center at Dallas are one step closer to understanding how high carbohydrate diets lead to obesity and diabetes.

Dr. Kosaku Uyeda, professor of biochemistry, has shown that a single protein called carbohydrate response element binding protein (ChREBP), discovered by his research group, activates several genes that cause cells in the liver to turn sugar into fat.

Their work appears in two studies in Proceedings of the National Academy of Sciences. The first study, published in an earlier issue, is available online, and the second, also online, will appear in an upcoming issue of PNAS.

"Purifying ChREBP from rat livers took two postdoctoral fellows two years of very hard work," said Dr. Uyeda, senior author of both studies and a research scientist at the Veterans Affairs North Texas Health Care System. "With the discovery of this factor, the biochemical mechanism of how carbohydrates are converted to fat has become clearer."

Eating meals high in carbohydrates or sugars leads the body to do several things. Some of the sugars are immediately converted to energy while the rest of the sugars are converted to fat. The sugar-to-fat conversion occurs two ways an immediate response, where enzymes are mobilized to rapidly convert sugars into fat; and a slower response, in which several different genes are turned on and off, creating more enzymes that can also turn sugar into fat. ChREBP is involved in the slow response.

ChREBP is a type of protein called a transcription factor. Transcription factors work in the cell nucleus to turn genes on and off in response to a signal. In the case of ChREBP, the signal is glucose, a simple sugar formed when carbohydrates are broken down during digestion. Glucose enters the bloodstream and, through transport molecules, enters cells where it is broken down into even smaller pieces. These smaller pieces are diverted from th
'"/>

Contact: Megha Satyanarayana
megha.saty@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
18-Oct-2004


Page: 1 2 3

Related biology news :

1. UT Southwestern joins national clinical trial to uncover long-term effects of West Nile virus
2. UT Southwestern leaders to receive national award for medical research accomplishments
3. UT Southwestern scientist receives NIH Directors Pioneer Award
4. UT Southwestern scientist named Keck Foundation Distinguished Young Scholar in Medical Research
5. UT Southwestern researchers find gene mutation that leads to broken hearts
6. Plague agent helps UT Southwestern researchers find novel signaling system in cells
7. One of the nations first 7-Tesla magnetic resonance imaging devices for human studies planned at UT Southwestern Medical Center
8. DNA end caps may lead to cancer treatments, UT Southwestern researchers report
9. UT Southwestern scientist honored among best in Texas research
10. UT Southwestern scientist receives international award for pediatric research
11. UT Southwestern physician-researcher wins international award for lipid research

Post Your Comments:
(Date:1/22/2015)... YORK and POINT ROBERTS, Washington ... news source covering leading sectors including technology and tech stocks, ... Privacy marketplace featuring master pickpocket and security consultant Apollo ... is stolen and talks about the Wocket™ biometric smart wallet, ...
(Date:1/22/2015)... N.C. , Jan. 22, 2015 Infinisource has launched ... of the G2 model. The G2 sets a higher standard ... iSolved human capital management solution. With plug-and-play installation, touch screen ... time clock provides a robust time collection solution for the ...
(Date:12/19/2014)... 18, 2014 Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ... 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - ... http://photos.prnewswire.com/prnh/20130307/600769 Following the ... fingerprint reading feature with the iPhone 5S. It is ...
Breaking Biology News(10 mins):Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3Infinisource's NXG series sets new time clock standard 2iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2
(Date:1/22/2015)... January 22, 2015 Crystal Diagnostics (CDx) Xpress ... it has received AOAC-PTM Certifications for the six non-O157 Shiga ... O145; collectively referred to as STEC or the “Big-6”) as ... forming unit (cfu) per 325 g of raw ground beef ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Selexis SA, ... mammalian Research Cell Banks (RCBs) used for drug discovery ... Cell Banks will include Next-Generation Sequencing (NGS) ... architecture de-risks biologic manufacturing by ensuring the integrity of ...
(Date:1/22/2015)... Jan. 22, 2015   GenoSpace , a precision medicine software ... enable the broad use of genomic, imaging and other biomedical ... of Michelle Munson , CEO of Aspera, an IBM ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 "We are ...
(Date:12/24/2014)... 2014  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical ... that the Company closed its previously announced private ... Jack W. Schuler , Birchview Fund LLC and ... before offering expenses.  The proceeds will be used ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2GenoSpace Expands Board with Appointment of Michelle Munson 2Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
Cached News: