UT Southwestern scientist named Keck Foundation Distinguished Young Scholar in Medica...( eren't for the leadership of Dr. Brown ...)

Drs. Brown and Goldstein received the Nobel Prize in physiology or medicine in 1985 for their discovery of the underlying mechanisms of cholesterol metabolism.

"Over the last 33 years, Mike Brown and I have been very fortunate in having had many superb postdoctoral fellows work with us," said Dr. Goldstein, chairman of molecular genetics. "Russell ranks among the very top in terms of his intelligence, creativity, judgment and technical prowess. He is following in the footsteps of other outstanding former fellows, such as Drs. David Russell [professor of molecular genetics], Thomas Sdhof [director of the Center for Basic Neuroscience], Helen Hobbs [director of the Eugene McDermott Center for Human Growth and Development and the Donald W. Reynolds Cardiovascular Research Center], Mark Lehrman [professor of pharmacology], Joachim Herz [professor of molecular genetics], Xiaodong Wang [professor of biochemistry] and Jay Horton [associate professor of internal medicine and molecular genetics], all of whom have remained at UT Southwestern where their independent careers have flourished."

Dr. Brown, director of the Erik Jonsson Center for Research in Molecular Genetics and Human Disease, added: "Dr. DeBose-Boyd has added a whole new chapter to our knowledge of the regulation of HMG CoA reductase. He has shown in detail how the enzyme is targeted for rapid degradation when certain sterols build up in cells, thereby stopping cholesterol synthesis. His work is conceptually brilliant, technically courageous and medically relevant. His selection as a Keck Scholar is eminently justified."

The W.M. Keck Foundation established the Distinguished Young Scholars in Medical Research Program in 1998 to support groundbreaking research addressing the fundamental mechanisms of human disease. Under the program, each grant recipient's home institution receives an award of up to $1 mi
'"/>

Contact: Amanda Siegfried
amanda.siegfried@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
25-Jul-2006