HOME >> BIOLOGY >> NEWS
UVa-led team uncovers important secret in gene replication

CHARLOTTESVILLE, Va., June 4, 2007 A team of researchers led by University of Virginia Health System geneticists has uncovered a major secret in the mystery of how the DNA helix replicates itself time after time. It turns out that it is not just the sequence of the bases (building blocks) in the DNA, but also how loosely or tightly the chromatin (the material that makes up chromosomes) is packed at different points of the chromosome that is critical.

Where chromatin is packed more loosely, the genes are replicated earlier than other genes and are expressed at high levels. Where chromatin is dense, these genes are replicated later and are not expressed.

Our work showed that by looking at time of replication, we could predict which genes are in an environment that could be expressed and the potential that cell has of going down different paths of differentiation, says Anindya Dutta, M.D., UVa professor of biochemistry and molecular genetics, who headed the replication portion of the major ENCODE project published in Nature journal (June 14). The time of replication of different parts of our genome is very nicely correlated with the chromatin packaging.

This finding held true for both cell lines studied, the HeLa cervical cancer cell line and a normal cell line (lymphocytic cells). To our surprise, what the HeLa cells were predicting in terms of chromatin packaging held true in the lymphocytes, even though the HeLa cells are cancer cells with scrambled genes, Dutta said. The chromatin packaging predictions were approximately comparable.

Chromosomes, then, are not just a framework of DNA but also are influenced by the proteins that pack the DNA, particularly histones. This packaging determines how the cells enzymes get access to the DNA to read off the DNA and replicate, ultimately to create all of the proteins needed by a given cell.

Several other researchers around the country were part of this larger project, th
'"/>

Contact: Mary Jane Gore
mjgore@virginia.edu
434-924-9241
University of Virginia Health System
13-Jun-2007


Page: 1 2 3

Related biology news :

1. Genomic analysis uncovers new targets for HIV vaccine
2. MIT-led team uncovers malaria mechanism
3. Analysis of rhesus monkey genome uncovers genetic differences with humans, chimps
4. Major gene study uncovers secrets of leukemia
5. UCLA study uncovers clues for why Graves disease attacks the eyes
6. Joslin-led study uncovers role of appetite hormone MCH in insulin production
7. Study uncovers a lethal secret of 1918 influenza virus
8. A laser uncovers the logic of the stomata function
9. Study uncovers mutation responsible for Noonan Syndrome
10. Unique imaging uncovers the invisible world where surfaces meet
11. UCLA study uncovers new risk factor for schizophrenia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/1/2018)... , ... August 31, 2018 , ... Right this minute, Frenchman Ben Lecomte is hard ... the Atlantic in 1998, he’s taken on a new challenge: going from Tokyo to San ... accompanied by his team on the support boat. As the first expedition of its kind, ...
(Date:8/31/2018)... MADISON, Wisc. (PRWEB) , ... August 30, 2018 ... ... to measure inhibitor residence times as a component of drug discovery programs. Longer-target ... deriving these residence times are low throughput, require expensive instrumentation, or require the ...
(Date:8/29/2018)... ... August 28, 2018 , ... Today, Bright ... that Data In Science Technologies has implemented Bright Cluster Manager at the HudsonAlpha ... a non-profit genomics and genetics research institute located in Huntsville, Ala. Its mission ...
Breaking Biology News(10 mins):
(Date:9/15/2018)... YORBA LINDA, Calif. (PRWEB) , ... September 14, 2018 , ... ... we treat patients. But even with new technologies, challenges remain. In the past, the ... challenge. , St. Jude Cloud is a new data ecosystem developed to advance ...
(Date:9/13/2018)... ... September 13, 2018 , ... Asymmetrex’s director, James L. ... have gotten in medicine, if we didn’t have the means to measure the number ... His answer, “Nowhere! And that is what’s holding up progress in stem cell ...
(Date:9/12/2018)... Calif. (PRWEB) , ... September 11, 2018 , ... ... exhibiting at the American Association of Feline Practitioners Conference (AAFP) later ... presenting data on adipose-derived stem cell therapy for the treatment of chronic kidney ...
(Date:9/12/2018)... ROCHELLE, Va. (PRWEB) , ... September 12, 2018 ... ... that Lauren Bronich-Hall, a quality management professional and former Senior Director of Regulatory ... Expert Consultant. , As Senior Director of Regulatory Affairs and Quality Systems ...
Breaking Biology Technology:
Cached News: