MONTREAL, November 18 2004 -- The biochemistry department of the Universit de Montral salutes the brilliant research performed by Julie Perroy, post-doctoral trainee, and Stphanie Pontier, graduate student, on the protein ubiquitination process. Their article describing this research work appears in the year-end review of the Nature Methods scientific publication. The work was performed under the direction of Michel Bouvier, Professor and Director of the Biochemistry Department of the Universit de Montral and holder of the Canada Research Chair in Signal Transduction and Molecular Pharmacology. Doctor Muriel Aubry, Professor, Biochemistry Department, also collaborated in the project.

As explained in their article, which was also featured in a News and Views article sponsored by the journal, Perroy and Pontier succeeded in demonstrating that the ubiquitination process of a given protein can be monitored dynamically, in real time, on living cells.

The study was made possible through the use of the BRET technique, developed previously in Professor Bouvier's laboratory. Thanks to these results, the different roles played by ubiquitin, a small protein that is attracting great interest, will become better known.

Nobel Prize for Chemistry in 2004

The work of Professor Bouvier and his team is part of the leading edge of an international research movement, which includes the 2004 winners of the Nobel Prize in Chemistry, Aaron Ciechanover, Avram Hershko and Irwin Rose, for their work on the role of ubiquitin in protein degradation. The three researchers will receive their prize on December 8 at Stockholm University, only a few days after the publication date of Nature Methods.

The research work of Professor Bouvier and his collaborators has had a major impact, which is likely to increase rapidly. "In the coming weeks, I expect we will have many requests for the biological material needed to implement this techniqu
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Contact: Sophie Langlois
sophie.langlois@umontreal.ca
514-343-7704
University of Montreal
18-Nov-2004

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